Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/RO4491533> ?p ?o }
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- RO4491533 abstract "RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3), being equipotent at mGluR2 and mGluR3 but without activity at other mGluR subtypes. In animal studies, RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379,268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341,495. A number of related compounds are known, with similar effects in vitro and a fairly well characterized structure-activity relationship.".
- RO4491533 atcPrefix "None".
- RO4491533 casNumber "579482-31-8".
- RO4491533 iupacName "4-[3-(2,6-dimethylpyridin-4-yl)phenyl]-7-methyl-8-trifluoromethyl-1,3-dihydrobenzo[b][1,4]diazepin-2-one".
- RO4491533 pubchem "11158623".
- RO4491533 thumbnail RO4491533_structure.png?width=300.
- RO4491533 wikiPageID "35644187".
- RO4491533 wikiPageLength "2463".
- RO4491533 wikiPageOutDegree "15".
- RO4491533 wikiPageRevisionID "667233796".
- RO4491533 wikiPageWikiLink Allosteric_modulator.
- RO4491533 wikiPageWikiLink Antidepressant.
- RO4491533 wikiPageWikiLink Binding_selectivity.
- RO4491533 wikiPageWikiLink Category:MGlu2_receptor_antagonists.
- RO4491533 wikiPageWikiLink Category:MGlu3_receptor_antagonists.
- RO4491533 wikiPageWikiLink Decoglurant.
- RO4491533 wikiPageWikiLink Drug.
- RO4491533 wikiPageWikiLink Hoffmann-La_Roche.
- RO4491533 wikiPageWikiLink LY-341,495.
- RO4491533 wikiPageWikiLink LY-379,268.
- RO4491533 wikiPageWikiLink Metabotropic_glutamate_receptor.
- RO4491533 wikiPageWikiLink Negative_allosteric_modulator.
- RO4491533 wikiPageWikiLink Potency_(pharmacology).
- RO4491533 wikiPageWikiLink Structure-activity_relationship.
- RO4491533 wikiPageWikiLink Structure–activity_relationship.
- RO4491533 wikiPageWikiLinkText "RO4491533".
- RO4491533 atcPrefix "None".
- RO4491533 c "24".
- RO4491533 casNumber "579482".
- RO4491533 f "3".
- RO4491533 h "20".
- RO4491533 hasPhotoCollection RO4491533.
- RO4491533 iupacName "4".
- RO4491533 iupharLigand "6226".
- RO4491533 legalStatus "Non-regulated".
- RO4491533 molecularWeight "423.43".
- RO4491533 n "3".
- RO4491533 o "1".
- RO4491533 pubchem "11158623".
- RO4491533 smiles "n3ccc-ccc4CCCNc1cc2CF".
- RO4491533 width "220".
- RO4491533 wikiPageUsesTemplate Template:Benzodiazepines.
- RO4491533 wikiPageUsesTemplate Template:Drugbox.
- RO4491533 wikiPageUsesTemplate Template:Glutamatergics.
- RO4491533 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- RO4491533 wikiPageUsesTemplate Template:Primary_sources.
- RO4491533 wikiPageUsesTemplate Template:Reflist.
- RO4491533 subject Category:MGlu2_receptor_antagonists.
- RO4491533 subject Category:MGlu3_receptor_antagonists.
- RO4491533 hypernym Drug.
- RO4491533 type Article.
- RO4491533 type ChemicalSubstance.
- RO4491533 type Drug.
- RO4491533 type Article.
- RO4491533 type Chemical.
- RO4491533 type Drug.
- RO4491533 type ChemicalObject.
- RO4491533 type Thing.
- RO4491533 type Q8386.
- RO4491533 comment "RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3), being equipotent at mGluR2 and mGluR3 but without activity at other mGluR subtypes. In animal studies, RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379,268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341,495.".
- RO4491533 label "RO4491533".
- RO4491533 sameAs m.0jkzwxc.
- RO4491533 sameAs RO4491533.
- RO4491533 sameAs RO4491533.
- RO4491533 sameAs Q7277302.
- RO4491533 sameAs Q7277302.
- RO4491533 wasDerivedFrom RO4491533?oldid=667233796.
- RO4491533 depiction RO4491533_structure.png.
- RO4491533 isPrimaryTopicOf RO4491533.