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- R-SMAD abstract "R-SMADs are receptor-regulated SMADs. SMADs are transcription factors that transduce extracellular TGF-β superfamily ligand signaling from cell membrane bound TGF-β receptors into the nucleus where they activate transcription TGF-β target genes. R-SMADS are directly phosphorylated on their c-terminus by type 1 TGF-β receptors through their intracellular kinase domain, leading to r-SMAD activation. R-SMADS include SMAD2 and SMAD3 from the TGF-β/Activin/Nodal branch, and SMAD1, SMAD5 and SMAD8 from the BMP/GDP branch of TGF-β signaling.R-SMADs include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-β superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4. Smad complexes then accumulate in the cell nucleus where they regulate transcription of specific target genes: SMAD2 and SMAD3 are activated in response to TGF-β/Activin or Nodal signals. SMAD1, SMAD5 and SMAD8 are activated in response to BMPs bone morphogenetic protein or GDP signals.SMAD6 and SMAD7 may be referred to as I-SMADs (inhibitory SMADS), which form trimers with r-SMADS and block their ability to induce gene transcription by competing with r-SMADs for receptor binding and by marking TGF-β receptors for degradation.".
- R-SMAD wikiPageExternalLink pmidlookup?view=long&pmid=11792802.
- R-SMAD wikiPageID "5689153".
- R-SMAD wikiPageLength "2681".
- R-SMAD wikiPageOutDegree "18".
- R-SMAD wikiPageRevisionID "592889112".
- R-SMAD wikiPageWikiLink Activin.
- R-SMAD wikiPageWikiLink Activin_and_inhibin.
- R-SMAD wikiPageWikiLink Bone_morphogenetic_protein.
- R-SMAD wikiPageWikiLink C-terminus.
- R-SMAD wikiPageWikiLink Category:Developmental_genes_and_proteins.
- R-SMAD wikiPageWikiLink Category:SMAD.
- R-SMAD wikiPageWikiLink Cell_nucleus.
- R-SMAD wikiPageWikiLink Kinase.
- R-SMAD wikiPageWikiLink Ligand.
- R-SMAD wikiPageWikiLink Mothers_against_decapentaplegic_homolog_1.
- R-SMAD wikiPageWikiLink Mothers_against_decapentaplegic_homolog_2.
- R-SMAD wikiPageWikiLink Mothers_against_decapentaplegic_homolog_3.
- R-SMAD wikiPageWikiLink Mothers_against_decapentaplegic_homolog_4.
- R-SMAD wikiPageWikiLink Mothers_against_decapentaplegic_homolog_5.
- R-SMAD wikiPageWikiLink Mothers_against_decapentaplegic_homolog_9.
- R-SMAD wikiPageWikiLink Phosphorylated.
- R-SMAD wikiPageWikiLink Phosphorylation.
- R-SMAD wikiPageWikiLink SMAD8.
- R-SMAD wikiPageWikiLink SMAD_(protein).
- R-SMAD wikiPageWikiLink TGF-β.
- R-SMAD wikiPageWikiLink Transforming_growth_factor_beta.
- R-SMAD wikiPageWikiLinkText "R-SMAD".
- R-SMAD wikiPageWikiLinkText "SMAD".
- R-SMAD wikiPageWikiLinkText "Smad".
- R-SMAD wikiPageWikiLinkText "Smads".
- R-SMAD wikiPageWikiLinkText "receptor regulated SMAD".
- R-SMAD hasPhotoCollection R-SMAD.
- R-SMAD wikiPageUsesTemplate Template:Cite_journal.
- R-SMAD wikiPageUsesTemplate Template:MeshName.
- R-SMAD wikiPageUsesTemplate Template:Molecular-cell-biology-stub.
- R-SMAD wikiPageUsesTemplate Template:Multiple_issues.
- R-SMAD wikiPageUsesTemplate Template:Reflist.
- R-SMAD wikiPageUsesTemplate Template:TGF_beta_signaling.
- R-SMAD wikiPageUsesTemplate Template:Transcription_factors.
- R-SMAD subject Category:Developmental_genes_and_proteins.
- R-SMAD subject Category:SMAD.
- R-SMAD type Article.
- R-SMAD type Article.
- R-SMAD type Concept.
- R-SMAD comment "R-SMADs are receptor-regulated SMADs. SMADs are transcription factors that transduce extracellular TGF-β superfamily ligand signaling from cell membrane bound TGF-β receptors into the nucleus where they activate transcription TGF-β target genes. R-SMADS are directly phosphorylated on their c-terminus by type 1 TGF-β receptors through their intracellular kinase domain, leading to r-SMAD activation.".
- R-SMAD label "R-SMAD".
- R-SMAD sameAs m.0d_720.
- R-SMAD sameAs Q7273271.
- R-SMAD sameAs Q7273271.
- R-SMAD wasDerivedFrom R-SMAD?oldid=592889112.
- R-SMAD isPrimaryTopicOf R-SMAD.