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- Prothrombinase abstract "The prothrombinase complex consists of the serine protein, Factor Xa, and the protein cofactor, Factor Va. The complex assembles on negatively charged phospholipid membranes in the presence of calcium ions. The prothrombinase complex catalyzes the conversion of prothrombin (Factor II), an inactive zymogen, to thrombin (Factor IIa), an active serine protease. The activation of thrombin is a critical reaction in the coagulation cascade, which functions to regulate hemostasis in the body. To produce thrombin, the prothrombinase complex cleaves two peptide bonds in prothrombin, one after Arg271 and the other after Arg320. Although it has been shown that Factor Xa can activate prothrombin when unassociated with the prothrombinase complex, the rate of thrombin formation is severely decreased under such circumstances. The prothrombinase complex can catalyze the activation of prothrombin at a rate 3 x 105-fold faster than can Factor Xa alone. Thus, the prothrombinase complex is required for the efficient production of activated thrombin and also for adequate hemostasis.".
- Prothrombinase wikiPageID "3150340".
- Prothrombinase wikiPageLength "24256".
- Prothrombinase wikiPageOutDegree "21".
- Prothrombinase wikiPageRevisionID "683214808".
- Prothrombinase wikiPageWikiLink Antithrombin.
- Prothrombinase wikiPageWikiLink Category:Coagulation_system.
- Prothrombinase wikiPageWikiLink Coagulation.
- Prothrombinase wikiPageWikiLink Coagulation_cascade.
- Prothrombinase wikiPageWikiLink Dabigatran.
- Prothrombinase wikiPageWikiLink Dabigatran_etexilate.
- Prothrombinase wikiPageWikiLink EGF-like_domain.
- Prothrombinase wikiPageWikiLink Factor_IX.
- Prothrombinase wikiPageWikiLink Factor_V.
- Prothrombinase wikiPageWikiLink Factor_VII.
- Prothrombinase wikiPageWikiLink Factor_VIII.
- Prothrombinase wikiPageWikiLink Factor_VIIa.
- Prothrombinase wikiPageWikiLink Factor_V_Leiden.
- Prothrombinase wikiPageWikiLink Factor_X.
- Prothrombinase wikiPageWikiLink Factor_Xa.
- Prothrombinase wikiPageWikiLink Fondaparinux.
- Prothrombinase wikiPageWikiLink Gla_domain.
- Prothrombinase wikiPageWikiLink Hemostasis.
- Prothrombinase wikiPageWikiLink Heparin.
- Prothrombinase wikiPageWikiLink Protein_C.
- Prothrombinase wikiPageWikiLink Tenase.
- Prothrombinase wikiPageWikiLink Thrombin.
- Prothrombinase wikiPageWikiLink Tissue_factor.
- Prothrombinase wikiPageWikiLinkText "prothrombinase complex".
- Prothrombinase wikiPageWikiLinkText "prothrombinase".
- Prothrombinase hasPhotoCollection Prothrombinase.
- Prothrombinase wikiPageUsesTemplate Template:Blood.
- Prothrombinase wikiPageUsesTemplate Template:Reflist.
- Prothrombinase subject Category:Coagulation_system.
- Prothrombinase comment "The prothrombinase complex consists of the serine protein, Factor Xa, and the protein cofactor, Factor Va. The complex assembles on negatively charged phospholipid membranes in the presence of calcium ions. The prothrombinase complex catalyzes the conversion of prothrombin (Factor II), an inactive zymogen, to thrombin (Factor IIa), an active serine protease. The activation of thrombin is a critical reaction in the coagulation cascade, which functions to regulate hemostasis in the body.".
- Prothrombinase label "Prothrombinase".
- Prothrombinase sameAs Prothrombinasekomplex.
- Prothrombinase sameAs m.08vnzq.
- Prothrombinase sameAs Протромбиназа.
- Prothrombinase sameAs Протромбин.
- Prothrombinase sameAs Q423640.
- Prothrombinase sameAs Q423640.
- Prothrombinase wasDerivedFrom Prothrombinase?oldid=683214808.
- Prothrombinase isPrimaryTopicOf Prothrombinase.