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- Prothrombin_G20210A abstract "Prothrombin G20210A (also the prothrombin 20210 mutation, the factor II mutation, or the prothrombin mutation) is a genetic variant that approximately doubles or triples the risk of forming blood clots in the veins. The variant is commonly associated with the disease venous thromboembolism (VTE), which includes both deep vein thrombosis and pulmonary embolism. Most carriers, though, never develop VTE in their lifetime.Prothrombin G20210A was identified in the 1990s, is almost exclusively present in Caucasians, and is estimated to have originated in that population slightly over 20,000 years ago. About 2 to 3% of Caucasians carry the variant, and it confers a 2- to 3-fold higher risk of VTE. Deficiencies in the anticoagulants Protein C and Protein S give a higher risk (5- to 10-fold). Behind non-O blood type and factor V Leiden, prothrombin G20210A is one of the most common genetic risk factors for VTE.The polymorphism is located in a noncoding region of the prothrombin gene (3' untranslated region nucleotide 20210), replacing guanine with adenine. The position is at or near where the pre-mRNA will have the poly-A tail attached. The variant causes elevated plasma prothrombin levels (hyperprothrombinemia), possibly due to increased pre-mRNA stability. Prothrombin is the precursor to thrombin, which plays a key role in causing blood to clot (blood coagulation). G20210A can thus contribute to a state of hypercoagulability, but not particularly with arterial thrombosis. A 2006 meta-analysis showed only a 1.3-fold increased risk for coronary disease.Heterozygous carriers who take oral contraceptives are at a 15-fold increased risk of VTE, while carriers also heterozygous with factor V Leiden have an approximate 20-fold higher risk. In a recommendation statement on VTE, genetic testing for G20210A in adults that developed unprovoked VTE was disadvised, as was testing in asymptomatic family members related to G20210A carriers who developed VTE. In those who develop VTE, the results of thrombophilia tests (wherein the variant can be detected) rarely play a role in the length of treatment.".
- Prothrombin_G20210A omim "176930".
- Prothrombin_G20210A wikiPageID "34423080".
- Prothrombin_G20210A wikiPageLength "6563".
- Prothrombin_G20210A wikiPageOutDegree "31".
- Prothrombin_G20210A wikiPageRevisionID "683699995".
- Prothrombin_G20210A wikiPageWikiLink 3_untranslated_region.
- Prothrombin_G20210A wikiPageWikiLink Adenine.
- Prothrombin_G20210A wikiPageWikiLink Arterial_thrombosis.
- Prothrombin_G20210A wikiPageWikiLink Blood_coagulation.
- Prothrombin_G20210A wikiPageWikiLink Blood_type.
- Prothrombin_G20210A wikiPageWikiLink Category:Coagulopathies.
- Prothrombin_G20210A wikiPageWikiLink Category:Single-nucleotide_polymorphisms.
- Prothrombin_G20210A wikiPageWikiLink Caucasian_race.
- Prothrombin_G20210A wikiPageWikiLink Coagulation.
- Prothrombin_G20210A wikiPageWikiLink Coronary_artery_disease.
- Prothrombin_G20210A wikiPageWikiLink Coronary_disease.
- Prothrombin_G20210A wikiPageWikiLink Deep_vein_thrombosis.
- Prothrombin_G20210A wikiPageWikiLink Factor_V_Leiden.
- Prothrombin_G20210A wikiPageWikiLink Genetic_testing.
- Prothrombin_G20210A wikiPageWikiLink Guanine.
- Prothrombin_G20210A wikiPageWikiLink Heterozygous.
- Prothrombin_G20210A wikiPageWikiLink Hypercoagulability.
- Prothrombin_G20210A wikiPageWikiLink Hyperprothrombinemia.
- Prothrombin_G20210A wikiPageWikiLink Meta-analysis.
- Prothrombin_G20210A wikiPageWikiLink Noncoding_DNA.
- Prothrombin_G20210A wikiPageWikiLink Oral_contraceptive_pill.
- Prothrombin_G20210A wikiPageWikiLink Oral_contraceptives.
- Prothrombin_G20210A wikiPageWikiLink Poly-A_tail.
- Prothrombin_G20210A wikiPageWikiLink Polyadenylation.
- Prothrombin_G20210A wikiPageWikiLink Protein_C.
- Prothrombin_G20210A wikiPageWikiLink Protein_S.
- Prothrombin_G20210A wikiPageWikiLink Prothrombin.
- Prothrombin_G20210A wikiPageWikiLink Pulmonary_embolism.
- Prothrombin_G20210A wikiPageWikiLink Sense_strand.
- Prothrombin_G20210A wikiPageWikiLink Single-nucleotide_polymorphism.
- Prothrombin_G20210A wikiPageWikiLink Start_codon.
- Prothrombin_G20210A wikiPageWikiLink Three_prime_untranslated_region.
- Prothrombin_G20210A wikiPageWikiLink Thrombin.
- Prothrombin_G20210A wikiPageWikiLink Thrombophilia.
- Prothrombin_G20210A wikiPageWikiLink Thrombosis.
- Prothrombin_G20210A wikiPageWikiLink Vein.
- Prothrombin_G20210A wikiPageWikiLink Venous_thromboembolism.
- Prothrombin_G20210A wikiPageWikiLink Venous_thrombosis.
- Prothrombin_G20210A wikiPageWikiLink Zygosity.
- Prothrombin_G20210A wikiPageWikiLinkText "F2 20210A".
- Prothrombin_G20210A wikiPageWikiLinkText "Prothrombin G20210A".
- Prothrombin_G20210A wikiPageWikiLinkText "prothrombin G20210A mutation".
- Prothrombin_G20210A wikiPageWikiLinkText "prothrombin G20210A".
- Prothrombin_G20210A diseasesdb "32790".
- Prothrombin_G20210A hasPhotoCollection Prothrombin_G20210A.
- Prothrombin_G20210A name "Prothrombin G20210A".
- Prothrombin_G20210A omim "176930".
- Prothrombin_G20210A wikiPageUsesTemplate Template:Efn.
- Prothrombin_G20210A wikiPageUsesTemplate Template:Infobox_disease.
- Prothrombin_G20210A wikiPageUsesTemplate Template:Notelist.
- Prothrombin_G20210A wikiPageUsesTemplate Template:Reflist.
- Prothrombin_G20210A subject Category:Coagulopathies.
- Prothrombin_G20210A subject Category:Single-nucleotide_polymorphisms.
- Prothrombin_G20210A hypernym Variant.
- Prothrombin_G20210A type Disease.
- Prothrombin_G20210A type Disorder.
- Prothrombin_G20210A type Thing.
- Prothrombin_G20210A type Q12136.
- Prothrombin_G20210A comment "Prothrombin G20210A (also the prothrombin 20210 mutation, the factor II mutation, or the prothrombin mutation) is a genetic variant that approximately doubles or triples the risk of forming blood clots in the veins. The variant is commonly associated with the disease venous thromboembolism (VTE), which includes both deep vein thrombosis and pulmonary embolism.".
- Prothrombin_G20210A label "Prothrombin G20210A".
- Prothrombin_G20210A sameAs Thrombophilie_par_mutation_G20210A_du_gène_de_la_prothrombine.
- Prothrombin_G20210A sameAs m.0h_cdbs.
- Prothrombin_G20210A sameAs Q7251810.
- Prothrombin_G20210A sameAs Q7251810.
- Prothrombin_G20210A wasDerivedFrom Prothrombin_G20210A?oldid=683699995.
- Prothrombin_G20210A isPrimaryTopicOf Prothrombin_G20210A.
- Prothrombin_G20210A name "Prothrombin G20210A".