Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Proteopathy> ?p ?o }
- Proteopathy abstract "In medicine, proteopathy (Proteo- [pref. protein]; -pathy [suff. disease]; proteopathies pl.; proteopathic adj.) refers to a class of diseases in which certain proteins become structurally abnormal, and thereby disrupt the function of cells, tissues and organs of the body. Often the proteins fail to fold into their normal configuration; in this misfolded state, the proteins can become toxic in some way (a gain of toxic function) or they can lose their normal function. The proteopathies (also known as proteinopathies, protein conformational disorders, or protein misfolding diseases) include such diseases as Creutzfeldt–Jakob disease, Alzheimer's disease, Parkinson's disease, prion disease, type 2 diabetes, amyloidosis, and a wide range of other disorders (see List of Proteopathies).The concept of proteopathy can trace its origins to the mid-19th century, when, in 1854, Rudolf Virchow coined the term amyloid ("starch-like") to describe a substance in cerebral corpora amylacea that exhibited a chemical reaction resembling that of cellulose. In 1859, Friedreich and Kekulé demonstrated that, rather than consisting of cellulose, "amyloid" actually is rich in protein. Subsequent research has shown that many different proteins can form amyloid, and that all amyloids have in common birefringence in cross-polarized light after staining with the dye Congo Red, as well as a fibrillar ultrastructure when viewed with an electron microscope. However, some proteinaceous lesions lack birefringence and contain few or no classical amyloid fibrils, such as the diffuse deposits of Aβ protein in the brains of Alzheimer patients. Furthermore, evidence has emerged that small, non-fibrillar protein aggregates known as oligomers are toxic to the cells of an affected organ, and that amyloidogenic proteins in their fibrillar form may be relatively benign.".
- Proteopathy thumbnail Proteopathy_Abeta_deposits_in_Alzheimer_disease.jpg?width=300.
- Proteopathy wikiPageExternalLink topic19.htm.
- Proteopathy wikiPageExternalLink topic3377.htm.
- Proteopathy wikiPageExternalLink topic662.htm.
- Proteopathy wikiPageID "10348140".
- Proteopathy wikiPageLength "24375".
- Proteopathy wikiPageOutDegree "159".
- Proteopathy wikiPageRevisionID "679021938".
- Proteopathy wikiPageWikiLink Alexander_disease.
- Proteopathy wikiPageWikiLink Alpha-synuclein.
- Proteopathy wikiPageWikiLink Alzheimers_disease.
- Proteopathy wikiPageWikiLink Amino_acid.
- Proteopathy wikiPageWikiLink Amylin.
- Proteopathy wikiPageWikiLink Amyloid.
- Proteopathy wikiPageWikiLink Amyloid_A.
- Proteopathy wikiPageWikiLink Amyloid_angiopathy.
- Proteopathy wikiPageWikiLink Amyloid_beta.
- Proteopathy wikiPageWikiLink Amyloidosis.
- Proteopathy wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Proteopathy wikiPageWikiLink Antibody.
- Proteopathy wikiPageWikiLink ApoAI.
- Proteopathy wikiPageWikiLink Apolipoprotein.
- Proteopathy wikiPageWikiLink Apolipoprotein_A1.
- Proteopathy wikiPageWikiLink Apolipoprotein_AI.
- Proteopathy wikiPageWikiLink Atrial_natriuretic_factor.
- Proteopathy wikiPageWikiLink Atrial_natriuretic_peptide.
- Proteopathy wikiPageWikiLink August_Kekulé.
- Proteopathy wikiPageWikiLink Aβ.
- Proteopathy wikiPageWikiLink Beta-2_microglobulin.
- Proteopathy wikiPageWikiLink Beta-sheet.
- Proteopathy wikiPageWikiLink Beta_sheet.
- Proteopathy wikiPageWikiLink Birefringence.
- Proteopathy wikiPageWikiLink CADASIL.
- Proteopathy wikiPageWikiLink CADASIL_syndrome.
- Proteopathy wikiPageWikiLink Calcifying_epithelial_odontogenic_tumor.
- Proteopathy wikiPageWikiLink Calcitonin.
- Proteopathy wikiPageWikiLink Carcinoma.
- Proteopathy wikiPageWikiLink Cataract.
- Proteopathy wikiPageWikiLink Cataracts.
- Proteopathy wikiPageWikiLink Category:Neurological_disorders.
- Proteopathy wikiPageWikiLink Category:Pathology.
- Proteopathy wikiPageWikiLink Category:Protein_folding.
- Proteopathy wikiPageWikiLink Cell_(biology).
- Proteopathy wikiPageWikiLink Cellulose.
- Proteopathy wikiPageWikiLink Cerebral_amyloid_angiopathy.
- Proteopathy wikiPageWikiLink Cerebral_hemorrhage.
- Proteopathy wikiPageWikiLink Congo_red.
- Proteopathy wikiPageWikiLink Corneal_dystrophy.
- Proteopathy wikiPageWikiLink Corpora_amylacea.
- Proteopathy wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Proteopathy wikiPageWikiLink Crystallin.
- Proteopathy wikiPageWikiLink Crystallins.
- Proteopathy wikiPageWikiLink Curli.
- Proteopathy wikiPageWikiLink Cystatin_C.
- Proteopathy wikiPageWikiLink Cystic_Fibrosis.
- Proteopathy wikiPageWikiLink Cystic_fibrosis.
- Proteopathy wikiPageWikiLink Cystic_fibrosis_transmembrane_conductance_regulator.
- Proteopathy wikiPageWikiLink Dementia.
- Proteopathy wikiPageWikiLink Diabetes_mellitus_type_2.
- Proteopathy wikiPageWikiLink Dialysis.
- Proteopathy wikiPageWikiLink Disease.
- Proteopathy wikiPageWikiLink Diseases.
- Proteopathy wikiPageWikiLink Electron_microscope.
- Proteopathy wikiPageWikiLink Escherichia_coli.
- Proteopathy wikiPageWikiLink FTLD.
- Proteopathy wikiPageWikiLink FUS.
- Proteopathy wikiPageWikiLink Fibrinogen.
- Proteopathy wikiPageWikiLink File:Proteopathy_Abeta_deposits_in_Alzheimer_disease.jpg.
- Proteopathy wikiPageWikiLink Friedreich.
- Proteopathy wikiPageWikiLink Friedrich_August_Kekulé_von_Stradonitz.
- Proteopathy wikiPageWikiLink Frontotemporal_lobar_degeneration.
- Proteopathy wikiPageWikiLink Gelsolin.
- Proteopathy wikiPageWikiLink Glaucoma.
- Proteopathy wikiPageWikiLink Glial_fibrillary_acidic_protein.
- Proteopathy wikiPageWikiLink Glutamine.
- Proteopathy wikiPageWikiLink Hemoglobin.
- Proteopathy wikiPageWikiLink Host_(biology).
- Proteopathy wikiPageWikiLink Huntingtons_disease.
- Proteopathy wikiPageWikiLink Hyperphosphorylation.
- Proteopathy wikiPageWikiLink Immunoglobulin.
- Proteopathy wikiPageWikiLink Inclusion_body_myositis.
- Proteopathy wikiPageWikiLink Intermediate_filament.
- Proteopathy wikiPageWikiLink Islet_amyloid_polypeptide.
- Proteopathy wikiPageWikiLink Keratin.
- Proteopathy wikiPageWikiLink Keratins.
- Proteopathy wikiPageWikiLink Lactoferrin.
- Proteopathy wikiPageWikiLink Lewy_bodies.
- Proteopathy wikiPageWikiLink Lewy_body.
- Proteopathy wikiPageWikiLink Lysozyme.
- Proteopathy wikiPageWikiLink Macromolecule.
- Proteopathy wikiPageWikiLink Macromolecules.
- Proteopathy wikiPageWikiLink Mallory_bodies.
- Proteopathy wikiPageWikiLink Mallory_body.
- Proteopathy wikiPageWikiLink Medicine.
- Proteopathy wikiPageWikiLink Monomer.
- Proteopathy wikiPageWikiLink Monomers.
- Proteopathy wikiPageWikiLink Myopathy.
- Proteopathy wikiPageWikiLink Myosin.
- Proteopathy wikiPageWikiLink Neurofibrillary_tangle.