Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Protein_moonlighting> ?p ?o }
- Protein_moonlighting abstract "Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.".
- Protein_moonlighting thumbnail 3EL3.png?width=300.
- Protein_moonlighting wikiPageID "30999216".
- Protein_moonlighting wikiPageLength "43346".
- Protein_moonlighting wikiPageOutDegree "168".
- Protein_moonlighting wikiPageRevisionID "682689837".
- Protein_moonlighting wikiPageWikiLink ATF2.
- Protein_moonlighting wikiPageWikiLink Aconitase.
- Protein_moonlighting wikiPageWikiLink Activating_transcription_factor_2.
- Protein_moonlighting wikiPageWikiLink Alcohol_oxidase.
- Protein_moonlighting wikiPageWikiLink Aldolase.
- Protein_moonlighting wikiPageWikiLink Alternative_splicing.
- Protein_moonlighting wikiPageWikiLink Alzheimers_disease.
- Protein_moonlighting wikiPageWikiLink Animal.
- Protein_moonlighting wikiPageWikiLink Antibiotic_resistance.
- Protein_moonlighting wikiPageWikiLink Antimicrobial_resistance.
- Protein_moonlighting wikiPageWikiLink Anuran.
- Protein_moonlighting wikiPageWikiLink Apoptosis.
- Protein_moonlighting wikiPageWikiLink Arabidopsis_thaliana.
- Protein_moonlighting wikiPageWikiLink Arg5,6.
- Protein_moonlighting wikiPageWikiLink Autocrine_signalling.
- Protein_moonlighting wikiPageWikiLink CYP170A1.
- Protein_moonlighting wikiPageWikiLink Casein_kinase_2.
- Protein_moonlighting wikiPageWikiLink Catalysis.
- Protein_moonlighting wikiPageWikiLink Catalyze.
- Protein_moonlighting wikiPageWikiLink Cataract.
- Protein_moonlighting wikiPageWikiLink Category:Evolutionary_biology.
- Protein_moonlighting wikiPageWikiLink Category:Molecular_genetics.
- Protein_moonlighting wikiPageWikiLink Category:Moonlighting_proteins.
- Protein_moonlighting wikiPageWikiLink Category:Proteins.
- Protein_moonlighting wikiPageWikiLink Cell_differentiation.
- Protein_moonlighting wikiPageWikiLink Cellular_differentiation.
- Protein_moonlighting wikiPageWikiLink Ceruloplasmin.
- Protein_moonlighting wikiPageWikiLink Chaperone_(protein).
- Protein_moonlighting wikiPageWikiLink Chemical_reaction.
- Protein_moonlighting wikiPageWikiLink Ciprofloxacin.
- Protein_moonlighting wikiPageWikiLink Citric_acid_cycle.
- Protein_moonlighting wikiPageWikiLink Conformational_change.
- Protein_moonlighting wikiPageWikiLink Conserved_sequence.
- Protein_moonlighting wikiPageWikiLink Cornea.
- Protein_moonlighting wikiPageWikiLink Crystallin.
- Protein_moonlighting wikiPageWikiLink Crystallins.
- Protein_moonlighting wikiPageWikiLink Cytochrome_c.
- Protein_moonlighting wikiPageWikiLink Dihydrolipoamide_dehydrogenase.
- Protein_moonlighting wikiPageWikiLink Drosophila_melanogaster.
- Protein_moonlighting wikiPageWikiLink Dual-polarization_interferometry.
- Protein_moonlighting wikiPageWikiLink Dual_polarization_interferometry.
- Protein_moonlighting wikiPageWikiLink ERK2.
- Protein_moonlighting wikiPageWikiLink ESCRT.
- Protein_moonlighting wikiPageWikiLink Ectoderm.
- Protein_moonlighting wikiPageWikiLink Enolase.
- Protein_moonlighting wikiPageWikiLink Enterobacter_aerogenes.
- Protein_moonlighting wikiPageWikiLink Enzyme.
- Protein_moonlighting wikiPageWikiLink Enzyme_catalysis.
- Protein_moonlighting wikiPageWikiLink Enzyme_promiscuity.
- Protein_moonlighting wikiPageWikiLink Epi-isozizaene_5-monooxygenase.
- Protein_moonlighting wikiPageWikiLink Escherichia_coli.
- Protein_moonlighting wikiPageWikiLink Evolution.
- Protein_moonlighting wikiPageWikiLink Flavin_group.
- Protein_moonlighting wikiPageWikiLink Frog.
- Protein_moonlighting wikiPageWikiLink Fungus.
- Protein_moonlighting wikiPageWikiLink Fusion_gene.
- Protein_moonlighting wikiPageWikiLink GAPDH.
- Protein_moonlighting wikiPageWikiLink Galactokinase.
- Protein_moonlighting wikiPageWikiLink Gene_duplication.
- Protein_moonlighting wikiPageWikiLink Gene_expression.
- Protein_moonlighting wikiPageWikiLink Gene_regulation.
- Protein_moonlighting wikiPageWikiLink Genotype.
- Protein_moonlighting wikiPageWikiLink Globin.
- Protein_moonlighting wikiPageWikiLink Glucose-6-phosphate_isomerase.
- Protein_moonlighting wikiPageWikiLink Glutamate_racemase.
- Protein_moonlighting wikiPageWikiLink Glutathione_peroxidase.
- Protein_moonlighting wikiPageWikiLink Glycation.
- Protein_moonlighting wikiPageWikiLink Glyceraldehyde_3-phosphate_dehydrogenase.
- Protein_moonlighting wikiPageWikiLink Glycolysis.
- Protein_moonlighting wikiPageWikiLink GroEL.
- Protein_moonlighting wikiPageWikiLink HSP60.
- Protein_moonlighting wikiPageWikiLink Hal3.
- Protein_moonlighting wikiPageWikiLink Hansenula_polymorpha.
- Protein_moonlighting wikiPageWikiLink Hexokinase.
- Protein_moonlighting wikiPageWikiLink Homing_endonuclease.
- Protein_moonlighting wikiPageWikiLink Horizontal_gene_transfer.
- Protein_moonlighting wikiPageWikiLink House_mouse.
- Protein_moonlighting wikiPageWikiLink HtrA_serine_peptidase_2.
- Protein_moonlighting wikiPageWikiLink Huntingtons_disease.
- Protein_moonlighting wikiPageWikiLink Immunohistochemistry.
- Protein_moonlighting wikiPageWikiLink In_vivo.
- Protein_moonlighting wikiPageWikiLink Inborn_error_of_metabolism.
- Protein_moonlighting wikiPageWikiLink Interactome.
- Protein_moonlighting wikiPageWikiLink Interactomics.
- Protein_moonlighting wikiPageWikiLink Ion_channel.
- Protein_moonlighting wikiPageWikiLink Iron-responsive_element-binding_protein.
- Protein_moonlighting wikiPageWikiLink Ischemia.
- Protein_moonlighting wikiPageWikiLink Joram_Piatigorsky.
- Protein_moonlighting wikiPageWikiLink Kingdom_(biology).
- Protein_moonlighting wikiPageWikiLink Kluyveromyces_lactis.
- Protein_moonlighting wikiPageWikiLink Lens_(anatomy).
- Protein_moonlighting wikiPageWikiLink MAPK1.
- Protein_moonlighting wikiPageWikiLink Mass-to-charge_ratio.
- Protein_moonlighting wikiPageWikiLink Mass_spectrometry.