Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Protein_C> ?p ?o }
- Protein_C abstract "Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease as it contains a residue of serine in its active site. In humans, protein C is encoded by the PROC gene, which is found on chromosome 2.The zymogenic form of protein C is a vitamin K-dependent glycoprotein that circulates in blood plasma. Its structure is that of a two-chain polypeptide consisting of a light chain and a heavy chain connected by a disulfide bond. The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs). Because of EPCR's role, activated protein C is found primarily near endothelial cells (i.e., those that make up the walls of blood vessels), and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of resistance to APC, suffer from a significantly increased risk of forming dangerous blood clots (thrombosis).Research into the clinical use of activated protein C also known as drotrecogin alfa-activated (branded Xigris) has been surrounded by controversy. The manufacturer Eli Lilly and Company ran an aggressive marketing campaign to promote its use in people with severe sepsis and septic shock including the sponsoring of the 2004Surviving Sepsis Campaign Guidelines. A 2011 Cochrane review however found that its use cannot be recommended as it does not improve survival (and increases bleeding risk).".
- Protein_C entrezgene "5624".
- Protein_C thumbnail Protein_C_1D_schematic.png?width=300.
- Protein_C wikiPageExternalLink summary.
- Protein_C wikiPageExternalLink ucm152843.htm.
- Protein_C wikiPageExternalLink aPC.htm.
- Protein_C wikiPageExternalLink Protein_C.htm.
- Protein_C wikiPageExternalLink 612283.
- Protein_C wikiPageExternalLink entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5624.
- Protein_C wikiPageExternalLink merops.cgi?id=S01.218.
- Protein_C wikiPageExternalLink index.html.
- Protein_C wikiPageExternalLink research.html.
- Protein_C wikiPageID "1364354".
- Protein_C wikiPageLength "44487".
- Protein_C wikiPageOutDegree "193".
- Protein_C wikiPageRevisionID "680907505".
- Protein_C wikiPageWikiLink Activated_protein_C_resistance.
- Protein_C wikiPageWikiLink Active_site.
- Protein_C wikiPageWikiLink Adolescence.
- Protein_C wikiPageWikiLink Angstrom.
- Protein_C wikiPageWikiLink Anticoagulant.
- Protein_C wikiPageWikiLink Anticoagulation.
- Protein_C wikiPageWikiLink Apoptosis.
- Protein_C wikiPageWikiLink Aromatic_amino_acids.
- Protein_C wikiPageWikiLink Atomic_mass_unit.
- Protein_C wikiPageWikiLink Autoantibody.
- Protein_C wikiPageWikiLink Bax_(biochemistry).
- Protein_C wikiPageWikiLink Bcl-2.
- Protein_C wikiPageWikiLink Bcl-2-associated_X_protein.
- Protein_C wikiPageWikiLink Blood_plasma.
- Protein_C wikiPageWikiLink Caspase_3.
- Protein_C wikiPageWikiLink Caspase_8.
- Protein_C wikiPageWikiLink Catalytic_triad.
- Protein_C wikiPageWikiLink Category:Angiology.
- Protein_C wikiPageWikiLink Category:Coagulation_system.
- Protein_C wikiPageWikiLink Category:EC_3.4.21.
- Protein_C wikiPageWikiLink Category:Hematology.
- Protein_C wikiPageWikiLink Category:Peripheral_membrane_proteins.
- Protein_C wikiPageWikiLink Category:Zymogens.
- Protein_C wikiPageWikiLink Cattle.
- Protein_C wikiPageWikiLink Caucasian_(race).
- Protein_C wikiPageWikiLink Caucasian_race.
- Protein_C wikiPageWikiLink Cell_adhesion_molecule.
- Protein_C wikiPageWikiLink Chemotaxis.
- Protein_C wikiPageWikiLink Chromosome.
- Protein_C wikiPageWikiLink Chromosome_2_(human).
- Protein_C wikiPageWikiLink Clinical_trial.
- Protein_C wikiPageWikiLink Coagulation.
- Protein_C wikiPageWikiLink Coagulation_factor_II_receptor.
- Protein_C wikiPageWikiLink Coagulopathy.
- Protein_C wikiPageWikiLink Cochrane_Collaboration.
- Protein_C wikiPageWikiLink Cochrane_review.
- Protein_C wikiPageWikiLink Cofactor_(biochemistry).
- Protein_C wikiPageWikiLink Compound_heterozygosity.
- Protein_C wikiPageWikiLink Compound_heterozygous.
- Protein_C wikiPageWikiLink Cow.
- Protein_C wikiPageWikiLink Cytokine.
- Protein_C wikiPageWikiLink Cytoprotection.
- Protein_C wikiPageWikiLink DEAE-Sepharose.
- Protein_C wikiPageWikiLink Decilitre.
- Protein_C wikiPageWikiLink Diabetes_mellitus_type_1.
- Protein_C wikiPageWikiLink Dimer_(chemistry).
- Protein_C wikiPageWikiLink Dipeptide.
- Protein_C wikiPageWikiLink Disseminated_intravascular_coagulation.
- Protein_C wikiPageWikiLink Disulfide.
- Protein_C wikiPageWikiLink Disulfide_bond.
- Protein_C wikiPageWikiLink Downregulation_and_upregulation.
- Protein_C wikiPageWikiLink Drotrecogin_alfa.
- Protein_C wikiPageWikiLink Drotrecogin_alfa_(activated).
- Protein_C wikiPageWikiLink EGF-like_domain.
- Protein_C wikiPageWikiLink Effector_(biology).
- Protein_C wikiPageWikiLink Eli_Lilly_and_Company.
- Protein_C wikiPageWikiLink Elution.
- Protein_C wikiPageWikiLink Embryo.
- Protein_C wikiPageWikiLink Endothelial_NOS.
- Protein_C wikiPageWikiLink Endothelial_cells.
- Protein_C wikiPageWikiLink Endothelial_protein_C_receptor.
- Protein_C wikiPageWikiLink Endothelium.
- Protein_C wikiPageWikiLink Endotoxin.
- Protein_C wikiPageWikiLink Enzyme_substrate.
- Protein_C wikiPageWikiLink Eosinophil.
- Protein_C wikiPageWikiLink Eosinophil_cationic_protein.
- Protein_C wikiPageWikiLink Eosinophil_granulocyte.
- Protein_C wikiPageWikiLink Erythropoietin.
- Protein_C wikiPageWikiLink Escherichia_coli.
- Protein_C wikiPageWikiLink Exon.
- Protein_C wikiPageWikiLink Exosite.
- Protein_C wikiPageWikiLink Exosite_(biology).
- Protein_C wikiPageWikiLink Factor_IX.
- Protein_C wikiPageWikiLink Factor_V.
- Protein_C wikiPageWikiLink Factor_VII.
- Protein_C wikiPageWikiLink Factor_VIII.
- Protein_C wikiPageWikiLink Factor_V_Leiden.
- Protein_C wikiPageWikiLink Factor_X.
- Protein_C wikiPageWikiLink Fibrin.
- Protein_C wikiPageWikiLink Food_and_Drug_Administration.
- Protein_C wikiPageWikiLink GLA_domain.
- Protein_C wikiPageWikiLink Gangrene.
- Protein_C wikiPageWikiLink Gene.
- Protein_C wikiPageWikiLink Gla_domain.