Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Proglumide> ?p ?o }
- Proglumide abstract "Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.Proglumide also works as a placebo effect amplifier for pain conditions. When injected visibly to a subject, its analgesic effect is bigger than a similarly administered placebo. When injected secretly, it does not have any effect, whereas standard pain drugs have an effect, even if they are administered without the subject's awareness. The supposed mechanism is an enhancement of the neural pathways of expectation as a result of dopamine and endogenous opioids being suddenly released throughout numerous structures of the brain and spinal cord. The ventral tegmental area is the structure believed to mediate proglumides analgesic and euphoric effects, however dozens of areas with a wide range of physical and psychological functions are implicated in the mediation of the placebo effect (this accounts for proglumides ability to produce physically measurable effects on vital signs such as heart rate, blood pressure, respiration rate, and tidal volume which can not be accounted for by its clinically insignificant δ-opioid affinity.".
- Proglumide atcPrefix "A02".
- Proglumide atcSuffix "BX06".
- Proglumide casNumber "6620-60-6".
- Proglumide chEBI "32058".
- Proglumide fdaUniiCode "EPL8W5565D".
- Proglumide iupacName "(RS)-N2-benzoyl-N,N-dipropyl-α-glutamine".
- Proglumide pubchem "4922".
- Proglumide thumbnail Proglumide_structure.svg?width=300.
- Proglumide wikiPageID "14409298".
- Proglumide wikiPageLength "8184".
- Proglumide wikiPageOutDegree "20".
- Proglumide wikiPageRevisionID "682232002".
- Proglumide wikiPageWikiLink Adjuvant.
- Proglumide wikiPageWikiLink Analgesia.
- Proglumide wikiPageWikiLink Analgesic.
- Proglumide wikiPageWikiLink Category:Amides.
- Proglumide wikiPageWikiLink Category:Benzamides.
- Proglumide wikiPageWikiLink Category:Cholecystokinin_antagonists.
- Proglumide wikiPageWikiLink Cholecystokinin_A_receptor.
- Proglumide wikiPageWikiLink Cholecystokinin_B_receptor.
- Proglumide wikiPageWikiLink Cholecystokinin_antagonist.
- Proglumide wikiPageWikiLink Delta_Opioid_receptor.
- Proglumide wikiPageWikiLink Drug.
- Proglumide wikiPageWikiLink Drug_tolerance.
- Proglumide wikiPageWikiLink Gastric_secretion.
- Proglumide wikiPageWikiLink Gastrointestinal.
- Proglumide wikiPageWikiLink Human_gastrointestinal_tract.
- Proglumide wikiPageWikiLink Motility.
- Proglumide wikiPageWikiLink Opioid.
- Proglumide wikiPageWikiLink Peptic_ulcer.
- Proglumide wikiPageWikiLink Proglumetacin.
- Proglumide wikiPageWikiLink Stomach.
- Proglumide wikiPageWikiLink Stomach_ulcers.
- Proglumide wikiPageWikiLink Tidal_volume.
- Proglumide wikiPageWikiLink Ventral_tegmental_area.
- Proglumide wikiPageWikiLink Vital_signs.
- Proglumide wikiPageWikiLink Δ-opioid_receptor.
- Proglumide wikiPageWikiLinkText "Proglumide".
- Proglumide wikiPageWikiLinkText "proglumide".
- Proglumide atcPrefix "A02".
- Proglumide atcSuffix "BX06".
- Proglumide c "18".
- Proglumide casNumber "6620".
- Proglumide chebi "32058".
- Proglumide chembl "316561".
- Proglumide chemspiderid "4753".
- Proglumide drugName "Proglumide".
- Proglumide eliminationHalfLife "86400.0".
- Proglumide h "26".
- Proglumide hasPhotoCollection Proglumide.
- Proglumide imagename "Chemical structure of proglumide".
- Proglumide inchi "1".
- Proglumide inchikey "DGMKFQYCZXERLX-UHFFFAOYAW".
- Proglumide iupacName "-N2-benzoyl-N,N-dipropyl-α-glutamine".
- Proglumide iupharLigand "893".
- Proglumide legalStatus "Rx-only".
- Proglumide molecularWeight "334.41".
- Proglumide n "2".
- Proglumide o "4".
- Proglumide pubchem "4922".
- Proglumide routesOfAdministration "Oral".
- Proglumide smiles "O=CC1=CC=CC=C1".
- Proglumide stdinchi "1".
- Proglumide stdinchikey "DGMKFQYCZXERLX-UHFFFAOYSA-N".
- Proglumide synonyms "(4-benzamido-5--5-oxopentanoic acid)".
- Proglumide unii "EPL8W5565D".
- Proglumide verifiedfields "changed".
- Proglumide verifiedrevid "405764009".
- Proglumide watchedfields "changed".
- Proglumide width "200".
- Proglumide wikiPageUsesTemplate Template:Drugbox.
- Proglumide wikiPageUsesTemplate Template:Drugs_for_peptic_ulcer_and_GORD.
- Proglumide wikiPageUsesTemplate Template:Neuropeptide_agonists_and_antagonists.
- Proglumide wikiPageUsesTemplate Template:Opioidergics.
- Proglumide wikiPageUsesTemplate Template:Reflist.
- Proglumide subject Category:Amides.
- Proglumide subject Category:Benzamides.
- Proglumide subject Category:Cholecystokinin_antagonists.
- Proglumide hypernym Drug.
- Proglumide type Article.
- Proglumide type ChemicalSubstance.
- Proglumide type Drug.
- Proglumide type Group.
- Proglumide type Amide.
- Proglumide type Antagonist.
- Proglumide type Article.
- Proglumide type Carboxamide.
- Proglumide type Chemical.
- Proglumide type Group.
- Proglumide type ChemicalObject.
- Proglumide type Thing.
- Proglumide type Q8386.
- Proglumide comment "Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs.".
- Proglumide label "Proglumide".
- Proglumide sameAs بروغلوميد.
- Proglumide sameAs プログルミド.
- Proglumide sameAs m.03d2myh.
- Proglumide sameAs Proglumid.
- Proglumide sameAs Proglumid.