Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Prion> ?p ?o }
- Prion abstract "A prion (/ˈpriːɒn/) is a protein that can fold in multiple, structurally distinct ways, at least one of which is transmissible to other prion proteins. It is this form of replication that leads to disease that is similar to viral infection. The word prion, coined in 1982 by Stanley B. Prusiner, is short for “proteinaceous infectious particle” derived from the words protein and infection, in reference to a prion's ability to self-propagate and transmit its conformation to other prions. While several yeast proteins have been identified as having prionogenic properties, the first prion protein was discovered in mammals and is referred to as the major prion protein (PrP). This infectious agent causes mammalian transmissible spongiform encephalopathies, including bovine spongiform encephalopathy (BSE, also known as "mad cow disease") and scrapie in sheep. In humans, PrP causes Creutzfeldt-Jakob Disease (CJD), variant Creutzfeldt-Jakob Disease (vCJD), Gerstmann–Sträussler–Scheinker syndrome, Fatal Familial Insomnia and kuru.A protein as an infectious agent stands in contrast to all other known infectious agents, like viruses, bacteria, fungi, or parasites—all of which must contain nucleic acids (either DNA, RNA, or both). All known prion diseases in mammals affect the structure of the brain or other neural tissue and all are currently untreatable and universally fatal.Prions are not considered living organisms because they are misfolded protein molecules which may propagate by transmitting a misfolded protein state. If a prion enters a healthy organism, it induces existing, properly folded proteins to convert into the misfolded prion form. In this way, the prion acts as a template to guide the misfolding of more proteins into prion form. In yeast, this refolding is assisted by chaperone proteins such as Hsp104p. These refolded prions can then go on to convert more proteins themselves, leading to a chain reaction resulting in large amounts of the prion form. All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly packed beta sheets. Amyloid aggregates are fibrils, growing at their ends, and replicate when breakage causes two growing ends to become four growing ends. The incubation period of prion diseases is determined by the exponential growth rate associated with prion replication, which is a balance between the linear growth and the breakage of aggregates. (Note that the propagation of the prion depends on the presence of normally folded protein in which the prion can induce misfolding; animals that do not express the normal form of the prion protein can neither develop nor transmit the disease.)Prion aggregates are extremely stable and accumulate in infected tissue, causing tissue damage and cell death. This structural stability means that prions are resistant to denaturation by chemical and physical agents, making disposal and containment of these particles difficult. Prion structure varies slightly between species, but nonetheless prion replication is subject to occasional epimutation and natural selection just like other forms of replication.".
- Prion icd10 "A81".
- Prion icd9 "046".
- Prion thumbnail Histology_bse.jpg?width=300.
- Prion wikiPageExternalLink annurev.neuro.31.060407.125620.
- Prion wikiPageExternalLink bseinquiry.gov.uk.
- Prion wikiPageExternalLink ind.universityofcalifornia.edu.
- Prion wikiPageExternalLink cjd.
- Prion wikiPageExternalLink display.
- Prion wikiPageExternalLink annurev-micro-092412-155735.
- Prion wikiPageExternalLink prions.
- Prion wikiPageExternalLink prionprotein.html.
- Prion wikiPageExternalLink susan-lindquist-part-1.html.
- Prion wikiPageExternalLink index.php?option=com_content&view=article&id=164&Itemid=153.
- Prion wikiPageExternalLink 90.001.0.01.htm.
- Prion wikiPageExternalLink dispomim.cgi?id=176640.
- Prion wikiPageExternalLink prion.
- Prion wikiPageExternalLink www.prion.ucl.ac.uk.
- Prion wikiPageExternalLink www.seac.gov.uk.
- Prion wikiPageExternalLink fulltext.
- Prion wikiPageExternalLink en.
- Prion wikiPageExternalLink ucsfmemoryandaging.
- Prion wikiPageID "23048".
- Prion wikiPageLength "89246".
- Prion wikiPageOutDegree "231".
- Prion wikiPageRevisionID "683647081".
- Prion wikiPageWikiLink AIDS.
- Prion wikiPageWikiLink Acinetobacter.
- Prion wikiPageWikiLink Aerosol.
- Prion wikiPageWikiLink Alpha_helix.
- Prion wikiPageWikiLink Alzheimers_disease.
- Prion wikiPageWikiLink Amino_acid.
- Prion wikiPageWikiLink Amyloid.
- Prion wikiPageWikiLink Amyloidosis.
- Prion wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Prion wikiPageWikiLink Animal_testing.
- Prion wikiPageWikiLink Astemizole.
- Prion wikiPageWikiLink Astrogliosis.
- Prion wikiPageWikiLink Ataxia.
- Prion wikiPageWikiLink Atomic_mass_unit.
- Prion wikiPageWikiLink Autoclave.
- Prion wikiPageWikiLink Bacteria.
- Prion wikiPageWikiLink Beta_sheet.
- Prion wikiPageWikiLink Biomolecular_structure.
- Prion wikiPageWikiLink Bleach.
- Prion wikiPageWikiLink Blood-brain-barrier.
- Prion wikiPageWikiLink Blood–brain_barrier.
- Prion wikiPageWikiLink Bone_marrow.
- Prion wikiPageWikiLink Bovine_spongiform_encephalopathy.
- Prion wikiPageWikiLink Brain.
- Prion wikiPageWikiLink Cat.
- Prion wikiPageWikiLink Category:Amyloidosis.
- Prion wikiPageWikiLink Category:Genetics.
- Prion wikiPageWikiLink Category:Prions.
- Prion wikiPageWikiLink Category:Proteins.
- Prion wikiPageWikiLink Cattle.
- Prion wikiPageWikiLink Caustic_soda.
- Prion wikiPageWikiLink Cell_(biology).
- Prion wikiPageWikiLink Cell_membrane.
- Prion wikiPageWikiLink Cell_wall.
- Prion wikiPageWikiLink Central_dogma_of_molecular_biology.
- Prion wikiPageWikiLink Central_nervous_system.
- Prion wikiPageWikiLink Chaperone_(protein).
- Prion wikiPageWikiLink Chronic_wasting_disease.
- Prion wikiPageWikiLink Concentration.
- Prion wikiPageWikiLink Convulsion.
- Prion wikiPageWikiLink Cooperativity.
- Prion wikiPageWikiLink Copper.
- Prion wikiPageWikiLink Creutzfeldt-Jakob_Disease.
- Prion wikiPageWikiLink Creutzfeldt-Jakob_disease.
- Prion wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Prion wikiPageWikiLink Current_Issues_in_Molecular_Biology.
- Prion wikiPageWikiLink Cytosol.
- Prion wikiPageWikiLink DNA.
- Prion wikiPageWikiLink Dartmouth_College.
- Prion wikiPageWikiLink David_Baltimore.
- Prion wikiPageWikiLink Dementia.
- Prion wikiPageWikiLink Denaturation_(biochemistry).
- Prion wikiPageWikiLink Dispersity.
- Prion wikiPageWikiLink Disulfide.
- Prion wikiPageWikiLink Disulfide_bond.
- Prion wikiPageWikiLink Domestic_sheep.
- Prion wikiPageWikiLink E._J._Field.
- Prion wikiPageWikiLink Enzyme.
- Prion wikiPageWikiLink Epigenetics.
- Prion wikiPageWikiLink Epimutation.
- Prion wikiPageWikiLink Exotic_ungulate_encephalopathy.
- Prion wikiPageWikiLink Exponential_growth.
- Prion wikiPageWikiLink Fatal_Familial_Insomnia.
- Prion wikiPageWikiLink Fatal_familial_insomnia.
- Prion wikiPageWikiLink Feline_spongiform_encephalopathy.
- Prion wikiPageWikiLink File:Prion_propagation.svg.
- Prion wikiPageWikiLink Formaldehyde.
- Prion wikiPageWikiLink Formalin.
- Prion wikiPageWikiLink Francis_Crick.
- Prion wikiPageWikiLink Frank_O_Bastian.
- Prion wikiPageWikiLink Frontotemporal_lobar_degeneration.
- Prion wikiPageWikiLink Fungal_prion.
- Prion wikiPageWikiLink Fungi.
- Prion wikiPageWikiLink Fungus.