Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Post-translational_modification> ?p ?o }
- Post-translational_modification abstract "Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins during or after protein biosynthesis. Proteins are synthesized by ribosomes translating mRNA into polypeptide chains, which may then undergo PTM to form the mature protein product. PTMs are important components in cell signaling.Post-translational modifications can occur on the amino acid side chains or at the protein's C- or N- termini. They can extend the chemical repertoire of the 20 standard amino acids by introducing new functional groups such as phosphate, acetate, amide groups, or methyl groups. Phosphorylation is a very common mechanism for regulating the activity of enzymes and is the most common post-translational modification. Many eukaryotic proteins also have carbohydrate molecules attached to them in a process called glycosylation, which can promote protein folding and improve stability as well as serving regulatory functions. Attachment of lipid molecules, known as lipidation, often targets a protein or part of a protein to the cell membrane.Other forms of post-translational modification consist of cleaving peptide bonds, as in processing a propeptide to a mature form or removing the initiator methionine residue. The formation of disulfide bonds from cysteine residues may also be referred to as a post-translational modification. For instance, the peptide hormone insulin is cut twice after disulfide bonds are formed, and a propeptide is removed from the middle of the chain; the resulting protein consists of two polypeptide chains connected by disulfide bonds.Some types of post-translational modification are consequences of oxidative stress. Carbonylation is one example that targets the modified protein for degradation and can result in the formation of protein aggregates. Specific amino acid modifications can be used as biomarkers indicating oxidative damage.Sites that often undergo post-translational modification are those that have a functional group that can serve as a nucleophile in the reaction: the hydroxyl groups of serine, threonine, and tyrosine; the amine forms of lysine, arginine, and histidine; the thiolate anion of cysteine; the carboxylates of aspartate and glutamate; and the N- and C-termini. In addition, although the amides of asparagine and glutamine are weak nucleophiles, both can serve as attachment points for glycans. Rarer modifications can occur at oxidized methionines and at some methylenes in side chains.Post-translational modification of proteins can be experimentally detected by a variety of techniques, including mass spectrometry, Eastern blotting, and Western blotting.".
- Post-translational_modification thumbnail Insulin_path.svg?width=300.
- Post-translational_modification wikiPageExternalLink ams2.bioinfo.pl.
- Post-translational_modification wikiPageExternalLink dbptm.mbc.nctu.edu.tw.
- Post-translational_modification wikiPageExternalLink PTMCuration.
- Post-translational_modification wikiPageExternalLink dcbo.cgi?type=KW;po=9991.
- Post-translational_modification wikiPageExternalLink deltaMasses.html.
- Post-translational_modification wikiPageExternalLink functional_analyses_for_sitesp.php.
- Post-translational_modification wikiPageExternalLink automotif_server_a_computation.php.
- Post-translational_modification wikiPageExternalLink 1tp8.
- Post-translational_modification wikiPageExternalLink ptmlist.
- Post-translational_modification wikiPageID "164901".
- Post-translational_modification wikiPageLength "17962".
- Post-translational_modification wikiPageOutDegree "236".
- Post-translational_modification wikiPageRevisionID "683758671".
- Post-translational_modification wikiPageWikiLink ADP-ribosylation.
- Post-translational_modification wikiPageWikiLink AIF5A.
- Post-translational_modification wikiPageWikiLink Acetyl.
- Post-translational_modification wikiPageWikiLink Acetylation.
- Post-translational_modification wikiPageWikiLink Acylation.
- Post-translational_modification wikiPageWikiLink Adenosine_monophosphate.
- Post-translational_modification wikiPageWikiLink Adenylyl.
- Post-translational_modification wikiPageWikiLink Adenylylation.
- Post-translational_modification wikiPageWikiLink Alanine.
- Post-translational_modification wikiPageWikiLink Alkene.
- Post-translational_modification wikiPageWikiLink Alkyl.
- Post-translational_modification wikiPageWikiLink Alkylation.
- Post-translational_modification wikiPageWikiLink Amidation.
- Post-translational_modification wikiPageWikiLink Amide.
- Post-translational_modification wikiPageWikiLink Amides.
- Post-translational_modification wikiPageWikiLink Amine.
- Post-translational_modification wikiPageWikiLink Amino_acid.
- Post-translational_modification wikiPageWikiLink Anion.
- Post-translational_modification wikiPageWikiLink Arginine.
- Post-translational_modification wikiPageWikiLink Arginylation.
- Post-translational_modification wikiPageWikiLink Asparagine.
- Post-translational_modification wikiPageWikiLink Aspartate.
- Post-translational_modification wikiPageWikiLink Aspartic_acid.
- Post-translational_modification wikiPageWikiLink Biomarker.
- Post-translational_modification wikiPageWikiLink Biotinylation.
- Post-translational_modification wikiPageWikiLink Butyrylation.
- Post-translational_modification wikiPageWikiLink C-terminus.
- Post-translational_modification wikiPageWikiLink Carbamylation.
- Post-translational_modification wikiPageWikiLink Carbohydrate.
- Post-translational_modification wikiPageWikiLink Carbonylation.
- Post-translational_modification wikiPageWikiLink Carboxyglutamic_acid.
- Post-translational_modification wikiPageWikiLink Carboxylate.
- Post-translational_modification wikiPageWikiLink Category:Cell_biology.
- Post-translational_modification wikiPageWikiLink Category:Gene_expression.
- Post-translational_modification wikiPageWikiLink Category:Posttranslational_modification.
- Post-translational_modification wikiPageWikiLink Category:Protein_biosynthesis.
- Post-translational_modification wikiPageWikiLink Category:Protein_structure.
- Post-translational_modification wikiPageWikiLink Cell_membrane.
- Post-translational_modification wikiPageWikiLink Citrullination.
- Post-translational_modification wikiPageWikiLink Citrulline.
- Post-translational_modification wikiPageWikiLink Coenzyme_A.
- Post-translational_modification wikiPageWikiLink Covalent.
- Post-translational_modification wikiPageWikiLink Covalent_bond.
- Post-translational_modification wikiPageWikiLink Cystein.
- Post-translational_modification wikiPageWikiLink Cysteine.
- Post-translational_modification wikiPageWikiLink DcGO.
- Post-translational_modification wikiPageWikiLink Deacetylation.
- Post-translational_modification wikiPageWikiLink Deamidation.
- Post-translational_modification wikiPageWikiLink Decarboxylation.
- Post-translational_modification wikiPageWikiLink Dehydration_reaction.
- Post-translational_modification wikiPageWikiLink Deltorphin.
- Post-translational_modification wikiPageWikiLink Demethylation.
- Post-translational_modification wikiPageWikiLink Dermorphin.
- Post-translational_modification wikiPageWikiLink Diphthamide.
- Post-translational_modification wikiPageWikiLink Disulfide.
- Post-translational_modification wikiPageWikiLink Disulfide_bond.
- Post-translational_modification wikiPageWikiLink Disulfide_bridge.
- Post-translational_modification wikiPageWikiLink EEF2.
- Post-translational_modification wikiPageWikiLink EIF5A.
- Post-translational_modification wikiPageWikiLink Eastern_blot.
- Post-translational_modification wikiPageWikiLink Eastern_blotting.
- Post-translational_modification wikiPageWikiLink Elimination_reaction.
- Post-translational_modification wikiPageWikiLink Eliminylation.
- Post-translational_modification wikiPageWikiLink Enzyme.
- Post-translational_modification wikiPageWikiLink Ester.
- Post-translational_modification wikiPageWikiLink Esters.
- Post-translational_modification wikiPageWikiLink Ethanolamine_phosphoglycerol.
- Post-translational_modification wikiPageWikiLink Ethyl_group.
- Post-translational_modification wikiPageWikiLink Eukaryote.
- Post-translational_modification wikiPageWikiLink Eukaryotic.
- Post-translational_modification wikiPageWikiLink Eukaryotic_translation_elongation_factor_1_alpha_1.
- Post-translational_modification wikiPageWikiLink FAD.
- Post-translational_modification wikiPageWikiLink Farnesol.
- Post-translational_modification wikiPageWikiLink Farnesylation.
- Post-translational_modification wikiPageWikiLink Flavin_adenine_dinucleotide.
- Post-translational_modification wikiPageWikiLink Flavin_group.
- Post-translational_modification wikiPageWikiLink Flavin_mononucleotide.
- Post-translational_modification wikiPageWikiLink Formylation.
- Post-translational_modification wikiPageWikiLink Functional_group.
- Post-translational_modification wikiPageWikiLink GPI_anchor.
- Post-translational_modification wikiPageWikiLink Gamma-carboxylation.
- Post-translational_modification wikiPageWikiLink Geranylgeraniol.
- Post-translational_modification wikiPageWikiLink Geranylgeranylation.
- Post-translational_modification wikiPageWikiLink Glutamate.
- Post-translational_modification wikiPageWikiLink Glutamic_acid.