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- Plasmepsin abstract "Plasmepsins are a class of at least 10 enzymes (EC 3.4.23.38 and EC 3.4.23.39) produced by the Plasmodium falciparum parasite. There are ten different isoforms of these proteins and ten genes coding them respectively in Plasmodium (Plm I, II, III, IV, V, VI, VII, IX, X and HAP). It has been suggested that the plasmpesin family is smaller in other human Plasmodium species. Expression of Plm I, II, IV, V, IX, X and HAP occurs in the erythrocytic cycle, and expression of Plm VI, VII, VIII, occurs in the exoerythrocytic cycle. Through their haemoglobin-degrading activity, they are an important cause of symptoms in malaria sufferers. Consequently this family of enzymes is a potential target for antimalarial drugs.Plasmepsins are aspartic acid proteases, meaning their active site contains two aspartic acid residues. These two aspartic acid residue act respectively as proton donor and proton acceptor, catalysing the hydrolysis of peptide bond in proteins.There are four types of plasmepsins, closely related but varying in the specificity of cleavage site. Plasmepsins I and II cleave hemoglobin between residues Phenylalanine 33 and Leucine 34 of α-globin subunit.The name plasmepsin may come from Plasmodium (the organism) and pepsin (a common aspartic acid protease with similar molecular structure).The closest (non-pathogenic) enzymatic equivalent in humans is the beta-secretase enzyme.".
- Plasmepsin ecNumber "3.4.23.38".
- Plasmepsin ecNumber "3.4.23.39".
- Plasmepsin thumbnail Plasmepsin.png?width=300.
- Plasmepsin wikiPageExternalLink merops.cgi?id=A01.022.
- Plasmepsin wikiPageExternalLink merops.cgi?id=A01.023.
- Plasmepsin wikiPageID "2688238".
- Plasmepsin wikiPageLength "3760".
- Plasmepsin wikiPageOutDegree "20".
- Plasmepsin wikiPageRevisionID "649331209".
- Plasmepsin wikiPageWikiLink Active_site.
- Plasmepsin wikiPageWikiLink Amino-acid.
- Plasmepsin wikiPageWikiLink Amino_acid.
- Plasmepsin wikiPageWikiLink Aspartate_protease.
- Plasmepsin wikiPageWikiLink Aspartic_acid.
- Plasmepsin wikiPageWikiLink Aspartic_acid_protease.
- Plasmepsin wikiPageWikiLink Beta-secretase_1.
- Plasmepsin wikiPageWikiLink Category:Plasmodium.
- Plasmepsin wikiPageWikiLink Hemoglobin.
- Plasmepsin wikiPageWikiLink Leucine.
- Plasmepsin wikiPageWikiLink MEROPS.
- Plasmepsin wikiPageWikiLink Malaria.
- Plasmepsin wikiPageWikiLink Pepsin.
- Plasmepsin wikiPageWikiLink Pepstatin.
- Plasmepsin wikiPageWikiLink Peptide_bond.
- Plasmepsin wikiPageWikiLink Phenylalanine.
- Plasmepsin wikiPageWikiLink Plasmodium.
- Plasmepsin wikiPageWikiLink Protease.
- Plasmepsin wikiPageWikiLink Proteases.
- Plasmepsin wikiPageWikiLink Protein.
- Plasmepsin wikiPageWikiLink Proteins.
- Plasmepsin wikiPageWikiLinkText "Plasmepsin".
- Plasmepsin wikiPageWikiLinkText "plasmepsin".
- Plasmepsin caption "Plasmepsin II complexed with".
- Plasmepsin caption "inhibitor pepstatin A.".
- Plasmepsin casNumber "159447".
- Plasmepsin casNumber "180189".
- Plasmepsin ecNumber "3.4".
- Plasmepsin hasPhotoCollection Plasmepsin.
- Plasmepsin iubmbEcNumber "3".
- Plasmepsin name "Plasmepsin I".
- Plasmepsin name "Plasmepsin II".
- Plasmepsin wikiPageUsesTemplate Template:Aspartic_acid_proteases.
- Plasmepsin wikiPageUsesTemplate Template:Cite_journal.
- Plasmepsin wikiPageUsesTemplate Template:EC_number.
- Plasmepsin wikiPageUsesTemplate Template:Enzyme.
- Plasmepsin wikiPageUsesTemplate Template:MeshName.
- Plasmepsin wikiPageUsesTemplate Template:Refbegin.
- Plasmepsin wikiPageUsesTemplate Template:Refend.
- Plasmepsin wikiPageUsesTemplate Template:Reflist.
- Plasmepsin subject Category:Plasmodium.
- Plasmepsin hypernym Class.
- Plasmepsin type Biomolecule.
- Plasmepsin type Enzyme.
- Plasmepsin type Thing.
- Plasmepsin type Q206229.
- Plasmepsin type Q8047.
- Plasmepsin comment "Plasmepsins are a class of at least 10 enzymes (EC 3.4.23.38 and EC 3.4.23.39) produced by the Plasmodium falciparum parasite. There are ten different isoforms of these proteins and ten genes coding them respectively in Plasmodium (Plm I, II, III, IV, V, VI, VII, IX, X and HAP). It has been suggested that the plasmpesin family is smaller in other human Plasmodium species.".
- Plasmepsin label "Plasmepsin".
- Plasmepsin sameAs m.07y1xy.
- Plasmepsin sameAs Q7201807.
- Plasmepsin sameAs Q7201807.
- Plasmepsin wasDerivedFrom Plasmepsin?oldid=649331209.
- Plasmepsin depiction Plasmepsin.png.
- Plasmepsin isPrimaryTopicOf Plasmepsin.
- Plasmepsin name "Plasmepsin I".
- Plasmepsin name "Plasmepsin II".