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- Pioneer_factor abstract "Pioneer factors are transcription factors that can directly bind condensed chromatin. They can have positive and negative effects on transcription and are important in recruiting other transcription factors and histone modification enzymes as well as controlling DNA methylation. They were first discovered in 2002 as factors capable of binding to target sites on nucleosomal DNA in compacted chromatin and endowing competency for gene activity during hepatogenesis. Pioneer factors are involved in initiating cell differentiation and activation of cell-specific genes. This property is observed in fork head box (FOX), Groucho TEL, and in Gal4 transcription factors.The eukaryotic cell condenses its genome into tightly packed chromatin and nucleosomes. This ability saves space in the nucleus for only actively transcribed genes and hides unnecessary or detrimental genes from being transcribed. Access to these condensed regions is done by chromatin remodelling by either balancing histone modifications or directly with pioneer factors that can loosen the chromatin themselves or as a flag recruiting other factors. Pioneer factors are not necessarily required for assembly of the transcription apparatus and may dissociate after being replaced by other factors.".
- Pioneer_factor thumbnail Pioneer_Factor_rearrange_the_nucleosome.jpg?width=300.
- Pioneer_factor wikiPageID "38664703".
- Pioneer_factor wikiPageLength "19717".
- Pioneer_factor wikiPageOutDegree "56".
- Pioneer_factor wikiPageRevisionID "679013965".
- Pioneer_factor wikiPageWikiLink Activating_protein_2.
- Pioneer_factor wikiPageWikiLink Anti-apoptotic_Ras_signalling_cascade.
- Pioneer_factor wikiPageWikiLink B-cell.
- Pioneer_factor wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- Pioneer_factor wikiPageWikiLink B_cell.
- Pioneer_factor wikiPageWikiLink Category:Gene_expression.
- Pioneer_factor wikiPageWikiLink Category:Protein_families.
- Pioneer_factor wikiPageWikiLink Category:Transcription_factors.
- Pioneer_factor wikiPageWikiLink Cell_nucleus.
- Pioneer_factor wikiPageWikiLink Cell_potency.
- Pioneer_factor wikiPageWikiLink Cellular_differentiation.
- Pioneer_factor wikiPageWikiLink Chromatin.
- Pioneer_factor wikiPageWikiLink CpG_island.
- Pioneer_factor wikiPageWikiLink CpG_site.
- Pioneer_factor wikiPageWikiLink Cysteine.
- Pioneer_factor wikiPageWikiLink DNA_methylation.
- Pioneer_factor wikiPageWikiLink Doxorubicin.
- Pioneer_factor wikiPageWikiLink Enhancer_(genetics).
- Pioneer_factor wikiPageWikiLink Estrogen.
- Pioneer_factor wikiPageWikiLink Estrogen_receptor.
- Pioneer_factor wikiPageWikiLink Eukaryote.
- Pioneer_factor wikiPageWikiLink FOXA1.
- Pioneer_factor wikiPageWikiLink FOXD3.
- Pioneer_factor wikiPageWikiLink FOXO3.
- Pioneer_factor wikiPageWikiLink FOX_proteins.
- Pioneer_factor wikiPageWikiLink UAS_system.
- Pioneer_factor wikiPageWikiLink GATA2.
- Pioneer_factor wikiPageWikiLink GATA3.
- Pioneer_factor wikiPageWikiLink GATA4.
- Pioneer_factor wikiPageWikiLink GATA_transcription_factor.
- Pioneer_factor wikiPageWikiLink Gene.
- Pioneer_factor wikiPageWikiLink Glucocorticoid_receptor.
- Pioneer_factor wikiPageWikiLink Histone.
- Pioneer_factor wikiPageWikiLink Histone_H1.
- Pioneer_factor wikiPageWikiLink Histone_code.
- Pioneer_factor wikiPageWikiLink Hormone.
- Pioneer_factor wikiPageWikiLink Imatinib.
- Pioneer_factor wikiPageWikiLink Insulin-like_growth_factor.
- Pioneer_factor wikiPageWikiLink MCF-7.
- Pioneer_factor wikiPageWikiLink Melanocyte.
- Pioneer_factor wikiPageWikiLink Mitosis.
- Pioneer_factor wikiPageWikiLink Neurofibromin_1.
- Pioneer_factor wikiPageWikiLink Nucleosome.
- Pioneer_factor wikiPageWikiLink PBX1.
- Pioneer_factor wikiPageWikiLink Paclitaxel.
- Pioneer_factor wikiPageWikiLink Pluripotent.
- Pioneer_factor wikiPageWikiLink Repressor.
- Pioneer_factor wikiPageWikiLink SPI1.
- Pioneer_factor wikiPageWikiLink Serum_albumin.
- Pioneer_factor wikiPageWikiLink Thyroid_peroxidase.
- Pioneer_factor wikiPageWikiLink Transcription_(genetics).
- Pioneer_factor wikiPageWikiLink Transcription_factor.
- Pioneer_factor wikiPageWikiLink Transcription_preinitiation_complex.
- Pioneer_factor wikiPageWikiLink Zinc_finger.
- Pioneer_factor wikiPageWikiLink File:Pioneer_Factor_in_the_Cell_Differentiation.jpg.
- Pioneer_factor wikiPageWikiLink File:Pioneer_Factor_rearrange_the_nucleosome.jpg.
- Pioneer_factor wikiPageWikiLink File:Pioneer_Factors_role_in_response_of_the_external_signal.jpg.
- Pioneer_factor wikiPageWikiLinkText "Pioneer factor".
- Pioneer_factor wikiPageWikiLinkText "Pioneering factors".
- Pioneer_factor wikiPageWikiLinkText "pioneer factor".
- Pioneer_factor wikiPageWikiLinkText "pioneering".
- Pioneer_factor hasPhotoCollection Pioneer_factor.
- Pioneer_factor wikiPageUsesTemplate Template:IPA.
- Pioneer_factor wikiPageUsesTemplate Template:Reflist.
- Pioneer_factor subject Category:Gene_expression.
- Pioneer_factor subject Category:Protein_families.
- Pioneer_factor subject Category:Transcription_factors.
- Pioneer_factor hypernym Factors.
- Pioneer_factor type Protein.
- Pioneer_factor type Factor.
- Pioneer_factor type Process.
- Pioneer_factor comment "Pioneer factors are transcription factors that can directly bind condensed chromatin. They can have positive and negative effects on transcription and are important in recruiting other transcription factors and histone modification enzymes as well as controlling DNA methylation. They were first discovered in 2002 as factors capable of binding to target sites on nucleosomal DNA in compacted chromatin and endowing competency for gene activity during hepatogenesis.".
- Pioneer_factor label "Pioneer factor".
- Pioneer_factor sameAs m.0r8l304.
- Pioneer_factor sameAs Q7196845.
- Pioneer_factor sameAs Q7196845.
- Pioneer_factor wasDerivedFrom Pioneer_factor?oldid=679013965.
- Pioneer_factor depiction Pioneer_Factor_rearrange_the_nucleosome.jpg.
- Pioneer_factor isPrimaryTopicOf Pioneer_factor.