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- PilZ_domain abstract "The PilZ protein family is named after the type IV pilus control protein first identified in Pseudomonas aeruginosa, expressed as part of the pil operon. It has a cytoplasmic location and is essential for type IV fimbrial, or pilus, biogenesis. PilZ is a c-di-GMP binding domain and PilZ domain-containing proteins represent the best studied class of c-di-GMP effectors. C-di-GMP, cyclic diguanosine monophosphate, the second messenger in cells, is widespread in and unique to the bacterial kingdom. Elevated intracellular levels of c-di-GMP generally cause bacteria to change from a motile single-cell state to a sessile, adhesive surface-attached multicellular state called biofilm.Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM and this is mediated via the c-di-GMP-PliZ complex. This interaction results in a reduction of torque-generation and induces counterclockwise motor bias that slows the motor and induces counterclockwise rotation, inhibiting chemotaxis.Binding and mutagenesis studies of several PilZ domain proteins have shown that c-di-GMP binding depends on residues in RxxxR and D/NxSxxG sequence-motifs. The crystal structure, at 1.7 A, of a PilZ domain::c-di-GMP complex from Vibrio cholerae shows c-di-GMP contacting seven of nine strongly conserved residues. Binding of c-di-GMP causes a conformational switch whereby the C- and N-terminal domains are brought into close opposition forming a new allosteric interaction surface that spans these domains and the c-di-GMP at their interface.The PilZ domain is also implicated in the bacterial pathogenicity of the Lyme disease spirochaete, Borrelia burgdorferi, through its binding partner c-di-GMP.".
- PilZ_domain symbol "PilZ".
- PilZ_domain thumbnail PDB_1ywu_EBI.jpg?width=300.
- PilZ_domain wikiPageID "31902906".
- PilZ_domain wikiPageLength "5460".
- PilZ_domain wikiPageOutDegree "32".
- PilZ_domain wikiPageRevisionID "671602863".
- PilZ_domain wikiPageWikiLink Adhesion.
- PilZ_domain wikiPageWikiLink Adhesive_surface_forces.
- PilZ_domain wikiPageWikiLink Allosteric_interaction.
- PilZ_domain wikiPageWikiLink Allosteric_regulation.
- PilZ_domain wikiPageWikiLink Biofilm.
- PilZ_domain wikiPageWikiLink Biogenesis.
- PilZ_domain wikiPageWikiLink Borrelia_burgdorferi.
- PilZ_domain wikiPageWikiLink Carrier_protein.
- PilZ_domain wikiPageWikiLink Category:Protein_domains.
- PilZ_domain wikiPageWikiLink Cell_(biology).
- PilZ_domain wikiPageWikiLink Chemotaxis.
- PilZ_domain wikiPageWikiLink Crystal_structure.
- PilZ_domain wikiPageWikiLink Cytoplasm.
- PilZ_domain wikiPageWikiLink Effector_(biology).
- PilZ_domain wikiPageWikiLink Fimbria_(bacteriology).
- PilZ_domain wikiPageWikiLink Flagellar_motility.
- PilZ_domain wikiPageWikiLink Flagellar_motor_switch.
- PilZ_domain wikiPageWikiLink Flagellum.
- PilZ_domain wikiPageWikiLink Intracellular.
- PilZ_domain wikiPageWikiLink Lyme_disease.
- PilZ_domain wikiPageWikiLink Motile.
- PilZ_domain wikiPageWikiLink Motility.
- PilZ_domain wikiPageWikiLink Multicellular_organism.
- PilZ_domain wikiPageWikiLink Mutagenesis,_site-directed.
- PilZ_domain wikiPageWikiLink Operon.
- PilZ_domain wikiPageWikiLink Pathogenicity.
- PilZ_domain wikiPageWikiLink Pilus.
- PilZ_domain wikiPageWikiLink Protein.
- PilZ_domain wikiPageWikiLink Protein–protein_interaction.
- PilZ_domain wikiPageWikiLink Pseudomonas_aeruginosa.
- PilZ_domain wikiPageWikiLink Sequence_motif.
- PilZ_domain wikiPageWikiLink Sessility_(zoology).
- PilZ_domain wikiPageWikiLink Site-directed_mutagenesis.
- PilZ_domain wikiPageWikiLink Spirochaete.
- PilZ_domain wikiPageWikiLink Torque.
- PilZ_domain wikiPageWikiLink Type_IV_pilus.
- PilZ_domain wikiPageWikiLink Vibrio_cholerae.
- PilZ_domain caption "the solution NMR structure of the protein of unknown function vca0042 from vibrio cholerae o1".
- PilZ_domain hasPhotoCollection PilZ_domain.
- PilZ_domain interpro "IPR009875".
- PilZ_domain name "PilZ".
- PilZ_domain pfam "PF07238".
- PilZ_domain symbol "PilZ".
- PilZ_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- PilZ_domain wikiPageUsesTemplate Template:InterPro_content.
- PilZ_domain wikiPageUsesTemplate Template:Orphan.
- PilZ_domain wikiPageUsesTemplate Template:Reflist.
- PilZ_domain subject Category:Protein_domains.
- PilZ_domain type Biomolecule.
- PilZ_domain type Protein.
- PilZ_domain type Chemical.
- PilZ_domain type Domain.
- PilZ_domain type Thing.
- PilZ_domain type Q206229.
- PilZ_domain type Q8054.
- PilZ_domain comment "The PilZ protein family is named after the type IV pilus control protein first identified in Pseudomonas aeruginosa, expressed as part of the pil operon. It has a cytoplasmic location and is essential for type IV fimbrial, or pilus, biogenesis. PilZ is a c-di-GMP binding domain and PilZ domain-containing proteins represent the best studied class of c-di-GMP effectors.".
- PilZ_domain label "PilZ domain".
- PilZ_domain sameAs m.0qfnblr.
- PilZ_domain sameAs Q7193726.
- PilZ_domain sameAs Q7193726.
- PilZ_domain wasDerivedFrom PilZ_domain?oldid=671602863.
- PilZ_domain depiction PDB_1ywu_EBI.jpg.
- PilZ_domain isPrimaryTopicOf PilZ_domain.