Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Phosphotyrosine-binding_domain> ?p ?o }
- Phosphotyrosine-binding_domain abstract "In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine.The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (Pfam PF00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.The phosphotyrosine-binding domain of insulin receptor substrate-1 is not related to the phosphotyrosine-binding domain of tensin.Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus. Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac-LYASSNPApY-NH2 peptide in the juxtamembrane region of the insulin receptor. Further interactions via "bridged" water molecules are coordinated by residues an Asn and a Ser residue. The PTB domain has a compact, 7-stranded beta-sandwich structure, capped by a C-terminal helix. The substrate peptide fits into an L-shaped surface cleft formed from the C-terminal helix and strands 5 and 6.".
- Phosphotyrosine-binding_domain symbol "IRS".
- Phosphotyrosine-binding_domain symbol "PTB".
- Phosphotyrosine-binding_domain thumbnail PDB_1wvh_EBI.jpg?width=300.
- Phosphotyrosine-binding_domain wikiPageID "24010095".
- Phosphotyrosine-binding_domain wikiPageLength "4778".
- Phosphotyrosine-binding_domain wikiPageOutDegree "60".
- Phosphotyrosine-binding_domain wikiPageRevisionID "607149346".
- Phosphotyrosine-binding_domain wikiPageWikiLink APBA1.
- Phosphotyrosine-binding_domain wikiPageWikiLink APBA2.
- Phosphotyrosine-binding_domain wikiPageWikiLink APBA3.
- Phosphotyrosine-binding_domain wikiPageWikiLink Acetylation.
- Phosphotyrosine-binding_domain wikiPageWikiLink Actin.
- Phosphotyrosine-binding_domain wikiPageWikiLink Actin_filaments.
- Phosphotyrosine-binding_domain wikiPageWikiLink Alpha_helix.
- Phosphotyrosine-binding_domain wikiPageWikiLink Amino_terminus.
- Phosphotyrosine-binding_domain wikiPageWikiLink Arginine.
- Phosphotyrosine-binding_domain wikiPageWikiLink Beta-sandwich.
- Phosphotyrosine-binding_domain wikiPageWikiLink C-terminus.
- Phosphotyrosine-binding_domain wikiPageWikiLink Category:Membrane_proteins.
- Phosphotyrosine-binding_domain wikiPageWikiLink Category:Protein_domains.
- Phosphotyrosine-binding_domain wikiPageWikiLink Category:Protein_families.
- Phosphotyrosine-binding_domain wikiPageWikiLink Cytoplasm.
- Phosphotyrosine-binding_domain wikiPageWikiLink Cytoplasmic.
- Phosphotyrosine-binding_domain wikiPageWikiLink DOK1.
- Phosphotyrosine-binding_domain wikiPageWikiLink DOK2.
- Phosphotyrosine-binding_domain wikiPageWikiLink DOK3.
- Phosphotyrosine-binding_domain wikiPageWikiLink DOK4.
- Phosphotyrosine-binding_domain wikiPageWikiLink DOK5.
- Phosphotyrosine-binding_domain wikiPageWikiLink DOK6.
- Phosphotyrosine-binding_domain wikiPageWikiLink Dok-7.
- Phosphotyrosine-binding_domain wikiPageWikiLink EPS8.
- Phosphotyrosine-binding_domain wikiPageWikiLink EPS8L1.
- Phosphotyrosine-binding_domain wikiPageWikiLink EPS8L2.
- Phosphotyrosine-binding_domain wikiPageWikiLink EPS8L3.
- Phosphotyrosine-binding_domain wikiPageWikiLink FRS2.
- Phosphotyrosine-binding_domain wikiPageWikiLink FRS3.
- Phosphotyrosine-binding_domain wikiPageWikiLink Focal_adhesion.
- Phosphotyrosine-binding_domain wikiPageWikiLink Human.
- Phosphotyrosine-binding_domain wikiPageWikiLink Hydrogen_bond.
- Phosphotyrosine-binding_domain wikiPageWikiLink Hydrogen_bonding.
- Phosphotyrosine-binding_domain wikiPageWikiLink IRS1.
- Phosphotyrosine-binding_domain wikiPageWikiLink IRS2.
- Phosphotyrosine-binding_domain wikiPageWikiLink IRS4.
- Phosphotyrosine-binding_domain wikiPageWikiLink Insulin_receptor.
- Phosphotyrosine-binding_domain wikiPageWikiLink Insulin_receptor_substrate_1.
- Phosphotyrosine-binding_domain wikiPageWikiLink Integrin.
- Phosphotyrosine-binding_domain wikiPageWikiLink List_of_protein_interactions.
- Phosphotyrosine-binding_domain wikiPageWikiLink Microfilament.
- Phosphotyrosine-binding_domain wikiPageWikiLink N-terminus.
- Phosphotyrosine-binding_domain wikiPageWikiLink N_terminus.
- Phosphotyrosine-binding_domain wikiPageWikiLink PTEN_(gene).
- Phosphotyrosine-binding_domain wikiPageWikiLink Peptide.
- Phosphotyrosine-binding_domain wikiPageWikiLink Phosphorylated.
- Phosphotyrosine-binding_domain wikiPageWikiLink Phosphorylation.
- Phosphotyrosine-binding_domain wikiPageWikiLink Phosphotyrosine.
- Phosphotyrosine-binding_domain wikiPageWikiLink Pleckstrin_homology_domain.
- Phosphotyrosine-binding_domain wikiPageWikiLink Properties_of_water.
- Phosphotyrosine-binding_domain wikiPageWikiLink Protein.
- Phosphotyrosine-binding_domain wikiPageWikiLink Protein_domain.
- Phosphotyrosine-binding_domain wikiPageWikiLink Protein_domains.
- Phosphotyrosine-binding_domain wikiPageWikiLink Protein_interaction.
- Phosphotyrosine-binding_domain wikiPageWikiLink Residue_(chemistry).
- Phosphotyrosine-binding_domain wikiPageWikiLink SH2_domain.
- Phosphotyrosine-binding_domain wikiPageWikiLink TENC1.
- Phosphotyrosine-binding_domain wikiPageWikiLink TLN1.
- Phosphotyrosine-binding_domain wikiPageWikiLink TLN2.
- Phosphotyrosine-binding_domain wikiPageWikiLink TNS1.
- Phosphotyrosine-binding_domain wikiPageWikiLink TNS3.
- Phosphotyrosine-binding_domain wikiPageWikiLink TNS4.
- Phosphotyrosine-binding_domain wikiPageWikiLink TNS_(protein).
- Phosphotyrosine-binding_domain wikiPageWikiLink Tensin.
- Phosphotyrosine-binding_domain wikiPageWikiLink Tumor_suppressor_gene.
- Phosphotyrosine-binding_domain wikiPageWikiLink Tumour_suppressor_gene.
- Phosphotyrosine-binding_domain wikiPageWikiLink Tyrosine.
- Phosphotyrosine-binding_domain wikiPageWikiLink Water_molecule.
- Phosphotyrosine-binding_domain wikiPageWikiLinkText "PI/PTB domain".
- Phosphotyrosine-binding_domain wikiPageWikiLinkText "PTB domain".
- Phosphotyrosine-binding_domain wikiPageWikiLinkText "Phosphotyrosine-binding domain".
- Phosphotyrosine-binding_domain wikiPageWikiLinkText "phosphotyrosine-binding".
- Phosphotyrosine-binding_domain caption "Structure of the PTB domain of tensin1.".
- Phosphotyrosine-binding_domain caption "irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, nmr, minimized average structure".
- Phosphotyrosine-binding_domain cdd "cd00934".
- Phosphotyrosine-binding_domain cdd "cd01204".
- Phosphotyrosine-binding_domain hasPhotoCollection Phosphotyrosine-binding_domain.
- Phosphotyrosine-binding_domain interpro "IPR002404".
- Phosphotyrosine-binding_domain interpro "IPR013625".
- Phosphotyrosine-binding_domain name "PTB domain".
- Phosphotyrosine-binding_domain name "Phosphotyrosine-binding domain".
- Phosphotyrosine-binding_domain pdb "A:1607-1738".
- Phosphotyrosine-binding_domain pfam "PF02174".
- Phosphotyrosine-binding_domain pfam "PF08416".
- Phosphotyrosine-binding_domain scop "1".
- Phosphotyrosine-binding_domain smart "PTBI".
- Phosphotyrosine-binding_domain symbol "IRS".
- Phosphotyrosine-binding_domain symbol "PTB".
- Phosphotyrosine-binding_domain wikiPageUsesTemplate Template:ELM.
- Phosphotyrosine-binding_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- Phosphotyrosine-binding_domain wikiPageUsesTemplate Template:InterPro_content.
- Phosphotyrosine-binding_domain wikiPageUsesTemplate Template:Membrane-protein-stub.