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- Phosphofructokinase abstract "Phosphofructokinase is a kinase enzyme that phosphorylates fructose 6-phosphate in glycolysis.The enzyme-catalysed transfer of a phosphoryl group from ATP is an important reaction in a wide variety of biological processes. One enzyme that utilizes this reaction is phosphofructokinase (PFK), which catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway. PFK exists as a homotetramer in bacteria and mammals (where each monomer possesses 2 similar domains) and as an octomer in yeast (where there are 4 alpha- (PFK1) and 4 beta-chains (PFK2), the latter, like the mammalian monomers, possessing 2 similar domains). This protein may use the morpheein model of allosteric regulation.PFK is about 300 amino acids in length, and structural studies of the bacterial enzyme have shown it comprises two similar (alpha/beta) lobes: one involved in ATP binding and the other housing both the substrate-binding site and the allosteric site (a regulatory binding site distinct from the active site, but that affects enzyme activity). The identical tetramer subunits adopt 2 different conformations: in a 'closed' state, the bound magnesium ion bridges the phosphoryl groups of the enzyme products (ADP and fructose-1,6- bisphosphate); and in an 'open' state, the magnesium ion binds only the ADP, as the 2 products are now further apart. These conformations are thought to be successive stages of a reaction pathway that requires subunit closure to bring the 2 molecules sufficiently close to react.Deficiency in PFK leads to glycogenosis type VII (Tarui's disease), an autosomal recessive disorder characterised by severe nausea, vomiting, muscle cramps and myoglobinuria in response to bursts of intense or vigorous exercise. Sufferers are usually able to lead a reasonably ordinary life by learning to adjust activity levels.".
- Phosphofructokinase symbol "Ppfruckinase".
- Phosphofructokinase thumbnail Beta-D-fructose-6-phosphate_wpmp.png?width=300.
- Phosphofructokinase wikiPageID "10751922".
- Phosphofructokinase wikiPageLength "5342".
- Phosphofructokinase wikiPageOutDegree "31".
- Phosphofructokinase wikiPageRevisionID "661825920".
- Phosphofructokinase wikiPageWikiLink Adenosine_triphosphate.
- Phosphofructokinase wikiPageWikiLink Allosteric_regulation.
- Phosphofructokinase wikiPageWikiLink Category:EC_2.7.1.
- Phosphofructokinase wikiPageWikiLink Category:Moonlighting_proteins.
- Phosphofructokinase wikiPageWikiLink Fructose-1,6-bisphosphate.
- Phosphofructokinase wikiPageWikiLink Fructose-2,6-bisphosphate.
- Phosphofructokinase wikiPageWikiLink Fructose-6-phosphate.
- Phosphofructokinase wikiPageWikiLink Fructose_1,6-bisphosphate.
- Phosphofructokinase wikiPageWikiLink Fructose_2,6-bisphosphate.
- Phosphofructokinase wikiPageWikiLink Fructose_6-phosphate.
- Phosphofructokinase wikiPageWikiLink Glycogenosis_type_VII.
- Phosphofructokinase wikiPageWikiLink Glycolysis.
- Phosphofructokinase wikiPageWikiLink Glycolytic_pathway.
- Phosphofructokinase wikiPageWikiLink Homotetramer.
- Phosphofructokinase wikiPageWikiLink KFC.
- Phosphofructokinase wikiPageWikiLink Kinase.
- Phosphofructokinase wikiPageWikiLink Morpheein.
- Phosphofructokinase wikiPageWikiLink PFKFB1.
- Phosphofructokinase wikiPageWikiLink PFKFB2.
- Phosphofructokinase wikiPageWikiLink PFKFB3.
- Phosphofructokinase wikiPageWikiLink PFKFB4.
- Phosphofructokinase wikiPageWikiLink PFKL.
- Phosphofructokinase wikiPageWikiLink PFKM.
- Phosphofructokinase wikiPageWikiLink PFKP.
- Phosphofructokinase wikiPageWikiLink Paktofonika.
- Phosphofructokinase wikiPageWikiLink Phosphofructokinase_1.
- Phosphofructokinase wikiPageWikiLink Phosphofructokinase_2.
- Phosphofructokinase wikiPageWikiLink Phosphofructokinase_deficiency.
- Phosphofructokinase wikiPageWikiLink Phosphorylation.
- Phosphofructokinase wikiPageWikiLink File:Beta-D-fructose-1,6-bisphosphate_wpmp.png.
- Phosphofructokinase wikiPageWikiLink File:Beta-D-fructose-6-phosphate_wpmp.png.
- Phosphofructokinase wikiPageWikiLink File:Fructose_2,6-bisphosphate.svg.
- Phosphofructokinase wikiPageWikiLinkText "PFK".
- Phosphofructokinase wikiPageWikiLinkText "Phosphofructokinase".
- Phosphofructokinase wikiPageWikiLinkText "one of the enzymes".
- Phosphofructokinase wikiPageWikiLinkText "phosphofructokinase".
- Phosphofructokinase wikiPageWikiLinkText "phosphofructokinase-1".
- Phosphofructokinase hasPhotoCollection Phosphofructokinase.
- Phosphofructokinase interpro "IPR000023".
- Phosphofructokinase name "Phosphofructokinase".
- Phosphofructokinase pfam "PF00365".
- Phosphofructokinase prosite "PDOC00336".
- Phosphofructokinase symbol "Ppfruckinase".
- Phosphofructokinase wikiPageUsesTemplate Template:Biochemistry-stub.
- Phosphofructokinase wikiPageUsesTemplate Template:EC_number.
- Phosphofructokinase wikiPageUsesTemplate Template:Further.
- Phosphofructokinase wikiPageUsesTemplate Template:Hatnote.
- Phosphofructokinase wikiPageUsesTemplate Template:InterPro_content.
- Phosphofructokinase wikiPageUsesTemplate Template:Kinases.
- Phosphofructokinase wikiPageUsesTemplate Template:MeshName.
- Phosphofructokinase wikiPageUsesTemplate Template:Pfam_box.
- Phosphofructokinase wikiPageUsesTemplate Template:Reflist.
- Phosphofructokinase subject Category:EC_2.7.1.
- Phosphofructokinase subject Category:Moonlighting_proteins.
- Phosphofructokinase hypernym Enzyme.
- Phosphofructokinase type Biomolecule.
- Phosphofructokinase type Protein.
- Phosphofructokinase type Thing.
- Phosphofructokinase type Q206229.
- Phosphofructokinase type Q8054.
- Phosphofructokinase comment "Phosphofructokinase is a kinase enzyme that phosphorylates fructose 6-phosphate in glycolysis.The enzyme-catalysed transfer of a phosphoryl group from ATP is an important reaction in a wide variety of biological processes. One enzyme that utilizes this reaction is phosphofructokinase (PFK), which catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway.".
- Phosphofructokinase label "Phosphofructokinase".
- Phosphofructokinase sameAs فوسفوفركتوكيناز.
- Phosphofructokinase sameAs Fosfofructokinase.
- Phosphofructokinase sameAs Fosfofructoquinasa.
- Phosphofructokinase sameAs Fosfofrutoquinase.
- Phosphofructokinase sameAs 6-fosfofruttochinasi.
- Phosphofructokinase sameAs ホスホフルクトキナーゼ.
- Phosphofructokinase sameAs Fosfofruktokinase.
- Phosphofructokinase sameAs Fosfofructokinase.
- Phosphofructokinase sameAs Fosfofruktokinaza.
- Phosphofructokinase sameAs Fosfofrutoquinase.
- Phosphofructokinase sameAs m.02qp19d.
- Phosphofructokinase sameAs Фосфофруктокиназа.
- Phosphofructokinase sameAs Fosfofruktokinaza.
- Phosphofructokinase sameAs Fosfofruktokinas.
- Phosphofructokinase sameAs Q14771739.
- Phosphofructokinase sameAs Q14771739.
- Phosphofructokinase wasDerivedFrom Phosphofructokinase?oldid=661825920.
- Phosphofructokinase depiction Beta-D-fructose-6-phosphate_wpmp.png.
- Phosphofructokinase isPrimaryTopicOf Phosphofructokinase.