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- Phosphatidylinositol_phosphate_kinases abstract "Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that are derivatives of phosphatidylinositol (PtdIns). It has been found that PtdIns is only phosphorylated on three (3,4,5) of its five hydroxyl groups, possibly because D-2 and D-6 hydroxyl groups cannot be phosphorylated because of steric hindrance. All 7 combinations of phosphorylated PtdIns have been found in animals, all except PtdIns(3,4,5)P3 have been found in plants.PIPKs are today divided into three groups, type I, II and III that share significant sequence homology but differ in the substrate specificities, subcellular localisations and functions.Type 1 are PIPKs that phosphorylate PtdIns4P to PtdIns(4,5)P2 and are called PtdIns4P 5-kinases because they phosphorylate on the D-5 hydroxyl group. Type II PIPKs phosphorylate PtdIns5P at the D-4 site and are called PtdIns5P 4-kinases. And finally PIPKs of type III are PtdIns3P 5-kinases that phosphorylate PtdIns to PtdIns(3,5)P2, which prototype is Fab1 in yeast (see [1] for descriptive picture). The substrate specificity of type I and II depends on the so-called activation loop. The activation loop is a segment of 22 to 27 amino acid residues, located close to the C-terminal end of the catalytic domain in all PIPKs. When the activation loops of a type I and a type II PIPK were swapped, the chimera with type I backbone showed specificity for type II substrate, and vice versa for the other chimera.".
- Phosphatidylinositol_phosphate_kinases wikiPageExternalLink JCS8533F1.jpeg.
- Phosphatidylinositol_phosphate_kinases wikiPageID "9060393".
- Phosphatidylinositol_phosphate_kinases wikiPageLength "2562".
- Phosphatidylinositol_phosphate_kinases wikiPageOutDegree "9".
- Phosphatidylinositol_phosphate_kinases wikiPageRevisionID "616142424".
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Amino_acid.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Animal.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Category:Enzymes.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Hydroxyl.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Kinase.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Phosphatidylinositol.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Phosphoinositide.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Plant.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLink Yeast.
- Phosphatidylinositol_phosphate_kinases wikiPageWikiLinkText "Phosphatidylinositol phosphate kinases".
- Phosphatidylinositol_phosphate_kinases hasPhotoCollection Phosphatidylinositol_phosphate_kinases.
- Phosphatidylinositol_phosphate_kinases wikiPageUsesTemplate Template:Enzyme-stub.
- Phosphatidylinositol_phosphate_kinases wikiPageUsesTemplate Template:Reflist.
- Phosphatidylinositol_phosphate_kinases subject Category:Enzymes.
- Phosphatidylinositol_phosphate_kinases hypernym Kinases.
- Phosphatidylinositol_phosphate_kinases type Article.
- Phosphatidylinositol_phosphate_kinases type Protein.
- Phosphatidylinositol_phosphate_kinases type Article.
- Phosphatidylinositol_phosphate_kinases comment "Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that are derivatives of phosphatidylinositol (PtdIns). It has been found that PtdIns is only phosphorylated on three (3,4,5) of its five hydroxyl groups, possibly because D-2 and D-6 hydroxyl groups cannot be phosphorylated because of steric hindrance.".
- Phosphatidylinositol_phosphate_kinases label "Phosphatidylinositol phosphate kinases".
- Phosphatidylinositol_phosphate_kinases sameAs m.027w6qf.
- Phosphatidylinositol_phosphate_kinases sameAs Q7187464.
- Phosphatidylinositol_phosphate_kinases sameAs Q7187464.
- Phosphatidylinositol_phosphate_kinases wasDerivedFrom Phosphatidylinositol_phosphate_kinases?oldid=616142424.
- Phosphatidylinositol_phosphate_kinases isPrimaryTopicOf Phosphatidylinositol_phosphate_kinases.