Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Periodic_fever_syndrome> ?p ?o }
- Periodic_fever_syndrome abstract "The periodic fever syndromes (also known as autoinflammatory diseases or autoinflammatory syndromes) are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation. Unlike autoimmune disorders such as systemic lupus erythematosus, in which the disease is caused by abnormalities of the adaptive immune system, patients with autoinflammatory diseases do not produce autoantibodies or antigen-specific T or B cells. Instead, the autoinflammatory diseases are characterized by errors in the innate immune system.The syndromes are diverse, but tend to cause episodes of fever, joint pains, skin rashes, abdominal pains and may lead to chronic complications such as amyloidosis.Most autoinflammatory diseases are genetic and present during childhood. The most common genetic autoinflammatory syndrome is familial Mediterranean fever, which causes short episodes of fever, abdominal pain, serositis, lasting less than 72 hours. It is caused by mutations in the MEFV gene, which codes for the protein pyrin.Pyrin is a protein normally present in the inflammasome. The mutated pyrin protein is thought to cause inappropriate activation of the inflammasome, leading to release of the pro-inflammatory cytokine IL-1β. Most other autoinflammatory diseases also cause disease by inappropriate release of IL-1β. Thus, IL-1β has become a common therapeutic target, and medications such as anakinra, rilonacept, and canakinumab have revolutionized the treatment of autoinflammatory diseases.However, there are some autoinflammatory diseases that are not known to have a clear genetic cause. This includes PFAPA, which is the most common autoinflammatory disease seen in children, characterized by episodes of fever, aphthous stomatitis, pharyngitis, and cervical adenitis. Other autoinflammatory diseases that do not have clear genetic causes include Adult-onset Still's disease, Systemic-onset juvenile idiopathic arthritis, Schnitzler syndrome, and Chronic recurrent multifocal osteomyelitis. It is likely that these diseases are multifactorial, with genes that make people susceptible to these diseases, but they require an additional environmental factor to trigger the disease.An other example that shows that autoinflamatory conditions may not be genetic in origin is found in a report published in Nature which shows that diet is very important in the development of such diseases. The ingestion levels of highly saturated fats and cholesterol, (high fat diet, HFD) affects the microbiota composition of the gut. Changes in the microbiota induced by a HFD are protective against the susceptibility to develop osteomyelitis (autoimmune disease) as compared with the changes induced by a low-fat diet. The changes in the microbiome of individuals under HFD showed a reduction in Prevotella abundance and were accompanied by significantly reduced expression levels of pro-Interleukin-1β in distant neutrophils.".
- Periodic_fever_syndrome icd10 "E85.0".
- Periodic_fever_syndrome icd9 "277.31".
- Periodic_fever_syndrome meshId "D056660".
- Periodic_fever_syndrome wikiPageExternalLink autoinflammatory-vs-autoimmune-whats-the-difference.
- Periodic_fever_syndrome wikiPageExternalLink default.asp.
- Periodic_fever_syndrome wikiPageExternalLink saidsupport.org.
- Periodic_fever_syndrome wikiPageID "6253974".
- Periodic_fever_syndrome wikiPageLength "6722".
- Periodic_fever_syndrome wikiPageOutDegree "59".
- Periodic_fever_syndrome wikiPageRevisionID "677947155".
- Periodic_fever_syndrome wikiPageWikiLink Abdominal_pain.
- Periodic_fever_syndrome wikiPageWikiLink Adaptive_immune_system.
- Periodic_fever_syndrome wikiPageWikiLink Adenitis.
- Periodic_fever_syndrome wikiPageWikiLink Adult-onset_Stills_disease.
- Periodic_fever_syndrome wikiPageWikiLink Amyloidosis.
- Periodic_fever_syndrome wikiPageWikiLink Anakinra.
- Periodic_fever_syndrome wikiPageWikiLink Aphthous_stomatitis.
- Periodic_fever_syndrome wikiPageWikiLink Arthralgia.
- Periodic_fever_syndrome wikiPageWikiLink Blau_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink Canakinumab.
- Periodic_fever_syndrome wikiPageWikiLink Category:Auto-inflammatory_diseases.
- Periodic_fever_syndrome wikiPageWikiLink Category:Inflammations.
- Periodic_fever_syndrome wikiPageWikiLink Category:Syndromes.
- Periodic_fever_syndrome wikiPageWikiLink Cholesterol.
- Periodic_fever_syndrome wikiPageWikiLink Chronic_recurrent_multifocal_osteomyelitis.
- Periodic_fever_syndrome wikiPageWikiLink Cold_urticaria.
- Periodic_fever_syndrome wikiPageWikiLink Cryopyrin-associated_periodic_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink Deficiency_of_the_interleukin-1–receptor_antagonist.
- Periodic_fever_syndrome wikiPageWikiLink Familial_Mediterranean_fever.
- Periodic_fever_syndrome wikiPageWikiLink Familial_cold_urticaria.
- Periodic_fever_syndrome wikiPageWikiLink Hyper-IgD_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink Hyperimmunoglobulinemia_D_with_recurrent_fever.
- Periodic_fever_syndrome wikiPageWikiLink IL-1β.
- Periodic_fever_syndrome wikiPageWikiLink IL1B.
- Periodic_fever_syndrome wikiPageWikiLink IL1RN.
- Periodic_fever_syndrome wikiPageWikiLink Inflammasome.
- Periodic_fever_syndrome wikiPageWikiLink Inflammation.
- Periodic_fever_syndrome wikiPageWikiLink Innate_immune_system.
- Periodic_fever_syndrome wikiPageWikiLink Interleukin_1_family.
- Periodic_fever_syndrome wikiPageWikiLink Interleukin_1_receptor_antagonist.
- Periodic_fever_syndrome wikiPageWikiLink List_of_cutaneous_conditions.
- Periodic_fever_syndrome wikiPageWikiLink MEFV.
- Periodic_fever_syndrome wikiPageWikiLink MVK.
- Periodic_fever_syndrome wikiPageWikiLink Methyl_vinyl_ketone.
- Periodic_fever_syndrome wikiPageWikiLink Mevalonate_kinase_deficiency.
- Periodic_fever_syndrome wikiPageWikiLink Mevalonic_aciduria.
- Periodic_fever_syndrome wikiPageWikiLink Microbiota.
- Periodic_fever_syndrome wikiPageWikiLink Muckle-Wells_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink Muckle–Wells_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink NALP3.
- Periodic_fever_syndrome wikiPageWikiLink NLRP3.
- Periodic_fever_syndrome wikiPageWikiLink NOD2.
- Periodic_fever_syndrome wikiPageWikiLink Nature_(journal).
- Periodic_fever_syndrome wikiPageWikiLink Neonatal_onset_multisystem_inflammatory_disease.
- Periodic_fever_syndrome wikiPageWikiLink Neutrophil_granulocyte.
- Periodic_fever_syndrome wikiPageWikiLink Neutrophils.
- Periodic_fever_syndrome wikiPageWikiLink OMIM.
- Periodic_fever_syndrome wikiPageWikiLink Online_Mendelian_Inheritance_in_Man.
- Periodic_fever_syndrome wikiPageWikiLink PAPA_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink PFAPA.
- Periodic_fever_syndrome wikiPageWikiLink PSTPIP1.
- Periodic_fever_syndrome wikiPageWikiLink Periodic_fever,_aphthous_stomatitis,_pharyngitis_and_adenitis.
- Periodic_fever_syndrome wikiPageWikiLink Pharyngitis.
- Periodic_fever_syndrome wikiPageWikiLink Prevotella.
- Periodic_fever_syndrome wikiPageWikiLink Pyogenic_sterile_arthritis,_pyoderma_gangrenosum,_acne.
- Periodic_fever_syndrome wikiPageWikiLink Pyrin.
- Periodic_fever_syndrome wikiPageWikiLink Rilonacept.
- Periodic_fever_syndrome wikiPageWikiLink Saturated_fat.
- Periodic_fever_syndrome wikiPageWikiLink Saturated_fats.
- Periodic_fever_syndrome wikiPageWikiLink Schnitzler_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink Serositis.
- Periodic_fever_syndrome wikiPageWikiLink Systemic-onset_juvenile_idiopathic_arthritis.
- Periodic_fever_syndrome wikiPageWikiLink TNFRSF1A.
- Periodic_fever_syndrome wikiPageWikiLink TNF_receptor_associated_periodic_syndrome.
- Periodic_fever_syndrome wikiPageWikiLink Tumor_necrosis_factor_receptor_1.
- Periodic_fever_syndrome wikiPageWikiLinkText "Autoinflammatory disease".
- Periodic_fever_syndrome wikiPageWikiLinkText "Periodic fever syndrome".
- Periodic_fever_syndrome wikiPageWikiLinkText "autoinflammatory".
- Periodic_fever_syndrome wikiPageWikiLinkText "periodic fever syndrome".
- Periodic_fever_syndrome diseasesdb "9836".
- Periodic_fever_syndrome emedicinesubj "article".
- Periodic_fever_syndrome emedicinetopic "952254".
- Periodic_fever_syndrome hasPhotoCollection Periodic_fever_syndrome.
- Periodic_fever_syndrome icd "277.31".
- Periodic_fever_syndrome icd "E85.0".
- Periodic_fever_syndrome meshid "D056660".
- Periodic_fever_syndrome name "Periodic fever syndrome".
- Periodic_fever_syndrome wikiPageUsesTemplate Template:Infobox_disease.
- Periodic_fever_syndrome wikiPageUsesTemplate Template:OMIM2.
- Periodic_fever_syndrome wikiPageUsesTemplate Template:Reflist.
- Periodic_fever_syndrome subject Category:Auto-inflammatory_diseases.
- Periodic_fever_syndrome subject Category:Inflammations.
- Periodic_fever_syndrome subject Category:Syndromes.
- Periodic_fever_syndrome hypernym Set.
- Periodic_fever_syndrome type Disease.
- Periodic_fever_syndrome type Syndrome.
- Periodic_fever_syndrome type Thing.
- Periodic_fever_syndrome type Q12136.
- Periodic_fever_syndrome comment "The periodic fever syndromes (also known as autoinflammatory diseases or autoinflammatory syndromes) are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation. Unlike autoimmune disorders such as systemic lupus erythematosus, in which the disease is caused by abnormalities of the adaptive immune system, patients with autoinflammatory diseases do not produce autoantibodies or antigen-specific T or B cells.".