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- Perhexiline abstract "Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency. Its clinical use has been limited by its narrow therapeutic index and high inter- and intra-individual pharmacokinetic variability. It was outlawed in many countries due to its adverse effects on poor metabolisers (PM). The product has been reintroduced for patients who have contraindications, or have not responded to, other treatments for angina.".
- Perhexiline atcPrefix "C08".
- Perhexiline atcSuffix "EX02".
- Perhexiline casNumber "6621-47-2".
- Perhexiline chEBI "35553".
- Perhexiline drugbank "DB01074".
- Perhexiline fdaUniiCode "KU65374X44".
- Perhexiline iupacName "2-(2,2-dicyclohexylethyl)piperidine".
- Perhexiline pubchem "4746".
- Perhexiline thumbnail Perhexiline_structure.svg?width=300.
- Perhexiline wikiPageID "3054011".
- Perhexiline wikiPageLength "7994".
- Perhexiline wikiPageOutDegree "20".
- Perhexiline wikiPageRevisionID "669035950".
- Perhexiline wikiPageWikiLink Antianginal.
- Perhexiline wikiPageWikiLink Antianginal_agent.
- Perhexiline wikiPageWikiLink Australia.
- Perhexiline wikiPageWikiLink Autosomal_recessive.
- Perhexiline wikiPageWikiLink CYP2D6.
- Perhexiline wikiPageWikiLink Carnitine_palmitoyltransferase_I.
- Perhexiline wikiPageWikiLink Category:Antianginals.
- Perhexiline wikiPageWikiLink Category:Piperidines.
- Perhexiline wikiPageWikiLink Contraindication.
- Perhexiline wikiPageWikiLink Dominance_(genetics).
- Perhexiline wikiPageWikiLink Hepatocyte.
- Perhexiline wikiPageWikiLink Hepatotoxicity.
- Perhexiline wikiPageWikiLink Histology.
- Perhexiline wikiPageWikiLink Mitochondrial_carnitine_palmitoyltransferase-1.
- Perhexiline wikiPageWikiLink New_Zealand.
- Perhexiline wikiPageWikiLink Peripheral_neuropathy.
- Perhexiline wikiPageWikiLink Pharmacokinetics.
- Perhexiline wikiPageWikiLink Phospholipidosis.
- Perhexiline wikiPageWikiLink Phospholipoidosis.
- Perhexiline wikiPageWikiLink Polymorphism_(biology).
- Perhexiline wikiPageWikiLink Poor_metaboliser.
- Perhexiline wikiPageWikiLink Schwann_cell.
- Perhexiline wikiPageWikiLink Schwann_cells.
- Perhexiline wikiPageWikiLink Therapeutic_index.
- Perhexiline wikiPageWikiLink Xenobiotic.
- Perhexiline wikiPageWikiLinkText "Perhexiline".
- Perhexiline wikiPageWikiLinkText "perhexiline".
- Perhexiline atcPrefix "8.0".
- Perhexiline atcSuffix "EX02".
- Perhexiline bioavailability "Dose Dependent".
- Perhexiline c "19".
- Perhexiline casNumber "6621".
- Perhexiline chebi "35553".
- Perhexiline chembl "75880".
- Perhexiline chemspiderid "4584".
- Perhexiline drugbank "DB01074".
- Perhexiline eliminationHalfLife "Dose Dependent".
- Perhexiline h "35".
- Perhexiline hasPhotoCollection Perhexiline.
- Perhexiline inchi "1".
- Perhexiline inchikey "CYXKNKQEMFBLER-UHFFFAOYAN".
- Perhexiline iupacName "2".
- Perhexiline kegg "D08340".
- Perhexiline metabolism "Saturable Hepatic".
- Perhexiline molecularWeight "277.488".
- Perhexiline n "1".
- Perhexiline pubchem "4746".
- Perhexiline routesOfAdministration "Oral".
- Perhexiline smiles "N3CCCCC3".
- Perhexiline stdinchi "1".
- Perhexiline stdinchikey "CYXKNKQEMFBLER-UHFFFAOYSA-N".
- Perhexiline unii "KU65374X44".
- Perhexiline verifiedrevid "464199017".
- Perhexiline wikiPageUsesTemplate Template:Calcium_channel_blockers.
- Perhexiline wikiPageUsesTemplate Template:Drugbox.
- Perhexiline wikiPageUsesTemplate Template:Reflist.
- Perhexiline subject Category:Antianginals.
- Perhexiline subject Category:Piperidines.
- Perhexiline hypernym Agent.
- Perhexiline type ChemicalSubstance.
- Perhexiline type Drug.
- Perhexiline type Antianginal.
- Perhexiline type Drug.
- Perhexiline type Heterocycle.
- Perhexiline type ChemicalObject.
- Perhexiline type Thing.
- Perhexiline type Q8386.
- Perhexiline comment "Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency.".
- Perhexiline label "Perhexiline".
- Perhexiline sameAs Perhexilin.
- Perhexiline sameAs m.08nfc4.
- Perhexiline sameAs Perheksilin.
- Perhexiline sameAs Perheksilin.
- Perhexiline sameAs Q1232737.
- Perhexiline sameAs Q1232737.
- Perhexiline wasDerivedFrom Perhexiline?oldid=669035950.
- Perhexiline depiction Perhexiline_structure.svg.
- Perhexiline isPrimaryTopicOf Perhexiline.