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- Pepducin abstract "Pepducins are novel cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic.Pepducins utilize lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell-signaling pathways. A Pepducin molecule comprises a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety. This structure allows Pepducin lipopeptides to anchor in the cell membrane lipid bilayer and target the GPCR/G protein interface via a unique intracellular allosteric mechanism. Pepducins for over 15 different GPCRs have been successfully produced, several of which have shown activity in preclinical in vivo models.An anti-PAR4 pepducin extended bleeding time in mice and protected against systemic platelet activation and thrombosis.A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells.A PAR1 pepducin, PZ-128, has successfully completed phase I clinical trials, and progress continues to be made.".
- Pepducin wikiPageID "19923477".
- Pepducin wikiPageLength "3908".
- Pepducin wikiPageOutDegree "20".
- Pepducin wikiPageRevisionID "679010580".
- Pepducin wikiPageWikiLink Agonist.
- Pepducin wikiPageWikiLink Allosteric.
- Pepducin wikiPageWikiLink Allosteric_regulation.
- Pepducin wikiPageWikiLink CXCR4.
- Pepducin wikiPageWikiLink Category:Lipopeptides.
- Pepducin wikiPageWikiLink Cell_membrane.
- Pepducin wikiPageWikiLink Cell_signaling.
- Pepducin wikiPageWikiLink Dr._Athan_Kuliopulos.
- Pepducin wikiPageWikiLink Dr._Lidija_Covic.
- Pepducin wikiPageWikiLink F2RL3.
- Pepducin wikiPageWikiLink G_protein.
- Pepducin wikiPageWikiLink G_protein-coupled_receptor.
- Pepducin wikiPageWikiLink G_protein–coupled_receptor.
- Pepducin wikiPageWikiLink Hydrophobe.
- Pepducin wikiPageWikiLink Hydrophobic.
- Pepducin wikiPageWikiLink In_vivo.
- Pepducin wikiPageWikiLink Intracellular.
- Pepducin wikiPageWikiLink Lipid_bilayer.
- Pepducin wikiPageWikiLink Lipopeptide.
- Pepducin wikiPageWikiLink Lipopeptides.
- Pepducin wikiPageWikiLink Moiety_(chemistry).
- Pepducin wikiPageWikiLink Molecule.
- Pepducin wikiPageWikiLink PAR4.
- Pepducin wikiPageWikiLink Peptide.
- Pepducin wikiPageWikiLink Peptides.
- Pepducin wikiPageWikiLink Tufts_Medical_Center.
- Pepducin wikiPageWikiLinkText "Pepducin".
- Pepducin wikiPageWikiLinkText "pepducin".
- Pepducin hasPhotoCollection Pepducin.
- Pepducin wikiPageUsesTemplate Template:Peptidergics.
- Pepducin wikiPageUsesTemplate Template:Reflist.
- Pepducin subject Category:Lipopeptides.
- Pepducin hypernym Peptides.
- Pepducin type Protein.
- Pepducin type Peptide.
- Pepducin comment "Pepducins are novel cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic.Pepducins utilize lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell-signaling pathways.".
- Pepducin label "Pepducin".
- Pepducin sameAs m.04q2w3x.
- Pepducin sameAs Q17143135.
- Pepducin sameAs Q17143135.
- Pepducin wasDerivedFrom Pepducin?oldid=679010580.
- Pepducin isPrimaryTopicOf Pepducin.