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- Parvulin abstract "Parvulin, a 92-amino acid protein discovered in E. coli in 1994, is the smallest known protein with prolyl isomerase activity, which catalyzes the cis-trans isomerization of proline peptide bonds. Although parvulin has no homology with larger prolyl isomerases such as cyclophilin and FKBP, it does share structural features with subdomains of other proteins involved in preparing secreted proteins for export from the cell.Although parvulin is as active as the larger prolyl isomerases against a short proline-containing test peptide, it has lower relative activity against biological substrates, possibly because the larger molecules have a higher ability to bind the substrate peptide. Parvulin itself contains proline residues and its folding can be accelerated by the presence of cyclophilin; parvulin folding can also be autocatalytic.A eukaryotic homolog of parvulin known as Pin1 is required to execute the transition from G2 phase to M phase in the cell cycle. Absence of Pin1 activity in humans has also been implicated in the folding and processing of the amyloid precursor protein, whose degradation product is the cytotoxic peptide amyloid beta implicated in Alzheimer's disease.In addition to Pin1, higher eucaryotes contain one more parvulin gene, whose core sequence is highly conserved in all multi-cellular organisms examined so far, but absent from yeast. In humans the locus of this parvulin resides on chromosome Xq13 and is encoding two protein species, Par14 and Par17. Par17 which is exclusively expressed in hominids and humans is an N-terminal extended version of Par14 and results from alternative transcription initiation.".
- Parvulin thumbnail Crystal_structure_of_human_Parvulin_14.jpg?width=300.
- Parvulin wikiPageExternalLink explore.do?structureId=3UI5.
- Parvulin wikiPageExternalLink explore.do?structureId=3ui4.
- Parvulin wikiPageExternalLink explore.do?structureId=3ui6.
- Parvulin wikiPageID "7118624".
- Parvulin wikiPageLength "4641".
- Parvulin wikiPageOutDegree "22".
- Parvulin wikiPageRevisionID "586646022".
- Parvulin wikiPageWikiLink Alzheimers_disease.
- Parvulin wikiPageWikiLink Amino_acid.
- Parvulin wikiPageWikiLink Amyloid_beta.
- Parvulin wikiPageWikiLink Amyloid_precursor_protein.
- Parvulin wikiPageWikiLink Autocatalysis.
- Parvulin wikiPageWikiLink Autocatalytic.
- Parvulin wikiPageWikiLink Category:EC_5.2.1.
- Parvulin wikiPageWikiLink Cell_(biology).
- Parvulin wikiPageWikiLink Cell_cycle.
- Parvulin wikiPageWikiLink Cis-trans_isomerism.
- Parvulin wikiPageWikiLink Cis–trans_isomerism.
- Parvulin wikiPageWikiLink Cyclophilin.
- Parvulin wikiPageWikiLink E._coli.
- Parvulin wikiPageWikiLink Escherichia_coli.
- Parvulin wikiPageWikiLink Eukaryote.
- Parvulin wikiPageWikiLink Eukaryotic.
- Parvulin wikiPageWikiLink FKBP.
- Parvulin wikiPageWikiLink G2_phase.
- Parvulin wikiPageWikiLink Homology_(biology).
- Parvulin wikiPageWikiLink M_phase.
- Parvulin wikiPageWikiLink Peptide.
- Parvulin wikiPageWikiLink Proline.
- Parvulin wikiPageWikiLink Prolyl_isomerase.
- Parvulin wikiPageWikiLink Protein_folding.
- Parvulin wikiPageWikiLink Secrete.
- Parvulin wikiPageWikiLink Secretion.
- Parvulin wikiPageWikiLink File:Crystal_structure_of_human_Parvulin_14.jpg.
- Parvulin wikiPageWikiLinkText "Parvulin".
- Parvulin wikiPageWikiLinkText "parvulin".
- Parvulin hasPhotoCollection Parvulin.
- Parvulin wikiPageUsesTemplate Template:Geometric_isomerases.
- Parvulin subject Category:EC_5.2.1.
- Parvulin hypernym Protein.
- Parvulin type Protein.
- Parvulin comment "Parvulin, a 92-amino acid protein discovered in E. coli in 1994, is the smallest known protein with prolyl isomerase activity, which catalyzes the cis-trans isomerization of proline peptide bonds.".
- Parvulin label "Parvulin".
- Parvulin sameAs m.0h50k3.
- Parvulin sameAs Q7141381.
- Parvulin sameAs Q7141381.
- Parvulin wasDerivedFrom Parvulin?oldid=586646022.
- Parvulin depiction Crystal_structure_of_human_Parvulin_14.jpg.
- Parvulin isPrimaryTopicOf Parvulin.