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- Paracellular_transport abstract "Paracellular transport refers to the transfer of substances across an epithelium by passing through the intercellular space between the cells. It is in contrast to transcellular transport, where the substances travel through the cell, passing through both the apical membrane and basolateral membrane.The distinction has particular significance in renal physiology and intestinal physiology. Transcellular transport often involves energy expenditure whereas paracellular transport is unmediated and passive down a concentration gradient. Paracellular transport also has the benefit that absorption rate is matched to load because it has no transporters that can be saturated.In most mammals, intestinal absorption of nutrients is thought to be dominated by transcellular transport, e.g., glucose is primarily absorbed via the SGLT1 transporter and other glucose transporters. Paracellular absorption therefore plays only a minor role in glucose absorption, although there is evidence that paracellular pathways become more available when nutrients are present in the intestinal lumen. In contrast, small flying vertebrates (small birds and bats) rely on the paracellular pathway for the majority of glucose absorption in the intestine. This has been hypothesized to compensate for an evolutionary pressure to reduce mass in flying animals, which resulted in a reduction in intestine size and faster transit time of food through the gut.Capillaries of the blood–brain barrier have only transcellular transport, in contrast with normal capillaries which have both transcellular and paracellular transport.The paracellular pathway of transport is also important for the absorption of drugs in the gastrointestinal tract. The paracellular pathway allows the permeation of hydrophilic molecules that are not able to permeate through the lipid membrane by the transcellular pathway of absorption. This is particularly important for hydrophilic pharmaceuticals, which may not have affinity for membrane-bound transporters, and therefore may be excluded from the transcellular pathway.The vast majority of drug molecules are transported through the transcellular pathway, and the few which rely on the paracellular pathway of transportation typically have a much lower bioavailability; for instance, levothyroxine has an oral bioavailability of 40 to 80%, and desmopressin of 0.16%.".
- Paracellular_transport wikiPageID "8275832".
- Paracellular_transport wikiPageLength "4896".
- Paracellular_transport wikiPageOutDegree "15".
- Paracellular_transport wikiPageRevisionID "678185179".
- Paracellular_transport wikiPageWikiLink Angstrom.
- Paracellular_transport wikiPageWikiLink Angstroms.
- Paracellular_transport wikiPageWikiLink Apical_membrane.
- Paracellular_transport wikiPageWikiLink Basolateral_membrane.
- Paracellular_transport wikiPageWikiLink Bioavailability.
- Paracellular_transport wikiPageWikiLink Category:Cell_biology.
- Paracellular_transport wikiPageWikiLink Cell_membrane.
- Paracellular_transport wikiPageWikiLink Claudin.
- Paracellular_transport wikiPageWikiLink Desmopressin.
- Paracellular_transport wikiPageWikiLink Digestion.
- Paracellular_transport wikiPageWikiLink Epithelium.
- Paracellular_transport wikiPageWikiLink Gastrointestinal_tract.
- Paracellular_transport wikiPageWikiLink Glucose_transporter.
- Paracellular_transport wikiPageWikiLink Levothyroxine.
- Paracellular_transport wikiPageWikiLink Oral_bioavailability.
- Paracellular_transport wikiPageWikiLink Renal_physiology.
- Paracellular_transport wikiPageWikiLink SGLT1.
- Paracellular_transport wikiPageWikiLink SLC5A1.
- Paracellular_transport wikiPageWikiLink Tight_junction.
- Paracellular_transport wikiPageWikiLink Transcellular_transport.
- Paracellular_transport wikiPageWikiLinkText "Paracellular transport".
- Paracellular_transport wikiPageWikiLinkText "paracellular permeability".
- Paracellular_transport wikiPageWikiLinkText "paracellular space".
- Paracellular_transport wikiPageWikiLinkText "paracellular transport".
- Paracellular_transport wikiPageWikiLinkText "paracellular".
- Paracellular_transport wikiPageWikiLinkText "paracellularly".
- Paracellular_transport hasPhotoCollection Paracellular_transport.
- Paracellular_transport wikiPageUsesTemplate Template:Citation_needed.
- Paracellular_transport wikiPageUsesTemplate Template:GeorgiaPhysiology.
- Paracellular_transport wikiPageUsesTemplate Template:Reflist.
- Paracellular_transport subject Category:Cell_biology.
- Paracellular_transport type Article.
- Paracellular_transport type Article.
- Paracellular_transport comment "Paracellular transport refers to the transfer of substances across an epithelium by passing through the intercellular space between the cells. It is in contrast to transcellular transport, where the substances travel through the cell, passing through both the apical membrane and basolateral membrane.The distinction has particular significance in renal physiology and intestinal physiology.".
- Paracellular_transport label "Paracellular transport".
- Paracellular_transport sameAs Parazellulärer_Transport.
- Paracellular_transport sameAs m.026ypt1.
- Paracellular_transport sameAs Q2051926.
- Paracellular_transport sameAs Q2051926.
- Paracellular_transport wasDerivedFrom Paracellular_transport?oldid=678185179.
- Paracellular_transport isPrimaryTopicOf Paracellular_transport.