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- PSB-10 abstract "PSB-10 is a drug which acts as a selective antagonist for the adenosine A3 receptor (ki value at human A3 receptor is 0.44 nM), with high selectivity over the other three adenosine receptor subtypes (ki values at human A1, A2A and A2B receptors are 4.1, 3.3 and 30 µM). Further pharmacological experiments in a [35S]GTPγS binding assay using hA3-CHO-cells indicated that PSB-10 acts as an inverse agonist (IC50 = 4 nM). It has been shown to produce antiinflammatory effects in animal studies. Simple xanthine derivatives such as caffeine and DPCPX have generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity. The affinity towards adenosine A3 subtype was measured against the radioligand PSB-11.".
- PSB-10 casNumber "591771-91-4".
- PSB-10 iupacName "(8R)-ethyl-4-methyl-2-(2,3,5-trichlorophenyl)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one".
- PSB-10 pubchem "10318703".
- PSB-10 thumbnail PSB-10.svg?width=300.
- PSB-10 wikiPageID "22520429".
- PSB-10 wikiPageLength "4141".
- PSB-10 wikiPageOutDegree "13".
- PSB-10 wikiPageRevisionID "673939619".
- PSB-10 wikiPageWikiLink 8-Cyclopentyl-1,3-dipropylxanthine.
- PSB-10 wikiPageWikiLink Adenosine.
- PSB-10 wikiPageWikiLink Adenosine_A3_receptor.
- PSB-10 wikiPageWikiLink Adenosine_receptor.
- PSB-10 wikiPageWikiLink Antagonist.
- PSB-10 wikiPageWikiLink Anti-inflammatory.
- PSB-10 wikiPageWikiLink Antiinflammatory.
- PSB-10 wikiPageWikiLink Caffeine.
- PSB-10 wikiPageWikiLink Category:Adenosine_receptor_antagonists.
- PSB-10 wikiPageWikiLink Category:Chloroarenes.
- PSB-10 wikiPageWikiLink Category:Imidazopurines.
- PSB-10 wikiPageWikiLink Category:Lactams.
- PSB-10 wikiPageWikiLink Dipropylcyclopentylxanthine.
- PSB-10 wikiPageWikiLink Receptor_(biochemistry).
- PSB-10 wikiPageWikiLink Xanthine.
- PSB-10 wikiPageWikiLinkText "PSB-10".
- PSB-10 c "16".
- PSB-10 casNumber "591771".
- PSB-10 cl "3".
- PSB-10 h "14".
- PSB-10 hasPhotoCollection PSB-10.
- PSB-10 iupacName "-ethyl-4-methyl-2--4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one".
- PSB-10 iupharLigand "5619".
- PSB-10 molecularWeight "400.69".
- PSB-10 n "5".
- PSB-10 o "1".
- PSB-10 pubchem "10318703".
- PSB-10 smiles "Clc2ccccCNC1C3NCN4C1=NCCC".
- PSB-10 synonyms "PSB-10".
- PSB-10 verifiedfields "changed".
- PSB-10 verifiedrevid "444488867".
- PSB-10 watchedfields "changed".
- PSB-10 width "240".
- PSB-10 wikiPageUsesTemplate Template:Adenosinergics.
- PSB-10 wikiPageUsesTemplate Template:Drugbox.
- PSB-10 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- PSB-10 wikiPageUsesTemplate Template:Reflist.
- PSB-10 subject Category:Adenosine_receptor_antagonists.
- PSB-10 subject Category:Chloroarenes.
- PSB-10 subject Category:Imidazopurines.
- PSB-10 subject Category:Lactams.
- PSB-10 hypernym Drug.
- PSB-10 type Article.
- PSB-10 type ChemicalSubstance.
- PSB-10 type Drug.
- PSB-10 type Amide.
- PSB-10 type Article.
- PSB-10 type Chemical.
- PSB-10 type Heterocycle.
- PSB-10 type Lactam.
- PSB-10 type Organohalide.
- PSB-10 type Organohalide.
- PSB-10 type ChemicalObject.
- PSB-10 type Thing.
- PSB-10 type Q8386.
- PSB-10 comment "PSB-10 is a drug which acts as a selective antagonist for the adenosine A3 receptor (ki value at human A3 receptor is 0.44 nM), with high selectivity over the other three adenosine receptor subtypes (ki values at human A1, A2A and A2B receptors are 4.1, 3.3 and 30 µM). Further pharmacological experiments in a [35S]GTPγS binding assay using hA3-CHO-cells indicated that PSB-10 acts as an inverse agonist (IC50 = 4 nM). It has been shown to produce antiinflammatory effects in animal studies.".
- PSB-10 label "PSB-10".
- PSB-10 sameAs m.05zx_q2.
- PSB-10 sameAs PSB-10.
- PSB-10 sameAs PSB-10.
- PSB-10 sameAs Q7120601.
- PSB-10 sameAs Q7120601.
- PSB-10 wasDerivedFrom PSB-10?oldid=673939619.
- PSB-10 depiction PSB-10.svg.
- PSB-10 isPrimaryTopicOf PSB-10.