Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/PRKAR2B> ?p ?o }
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- PRKAR2B abstract "cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.".
- PRKAR2B entrezgene "5577".
- PRKAR2B wikiPageID "14754256".
- PRKAR2B wikiPageLength "11837".
- PRKAR2B wikiPageOutDegree "5".
- PRKAR2B wikiPageRevisionID "673309944".
- PRKAR2B wikiPageWikiLink AKAP11.
- PRKAR2B wikiPageWikiLink CAMP-dependent_protein_kinase.
- PRKAR2B wikiPageWikiLink Enzyme.
- PRKAR2B wikiPageWikiLink Gene.
- PRKAR2B wikiPageWikiLink Protein-protein_interaction.
- PRKAR2B wikiPageWikiLink Protein_kinase_A.
- PRKAR2B wikiPageWikiLink Protein–protein_interaction.
- PRKAR2B wikiPageWikiLinkText "PRKAR2B".
- PRKAR2B hasPhotoCollection PRKAR2B.
- PRKAR2B requireManualInspection "no".
- PRKAR2B summaryText "cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase , which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.".
- PRKAR2B updateCitations "yes".
- PRKAR2B updatePage "yes".
- PRKAR2B updateProteinBox "yes".
- PRKAR2B updateSummary "yes".
- PRKAR2B wikiPageUsesTemplate Template:Gene-7-stub.
- PRKAR2B wikiPageUsesTemplate Template:PBB.
- PRKAR2B wikiPageUsesTemplate Template:PBB_Controls.
- PRKAR2B wikiPageUsesTemplate Template:PBB_Further_reading.
- PRKAR2B wikiPageUsesTemplate Template:PBB_Summary.
- PRKAR2B wikiPageUsesTemplate Template:PDB_Gallery.
- PRKAR2B wikiPageUsesTemplate Template:Refbegin.
- PRKAR2B wikiPageUsesTemplate Template:Refend.
- PRKAR2B wikiPageUsesTemplate Template:Reflist.
- PRKAR2B hypernym Enzyme.
- PRKAR2B type Biomolecule.
- PRKAR2B type Protein.
- PRKAR2B type Thing.
- PRKAR2B type Q206229.
- PRKAR2B type Q8054.
- PRKAR2B comment "cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits.".
- PRKAR2B label "PRKAR2B".
- PRKAR2B sameAs m.03gwqmw.
- PRKAR2B sameAs Q7120336.
- PRKAR2B sameAs Q7120336.
- PRKAR2B wasDerivedFrom PRKAR2B?oldid=673309944.
- PRKAR2B isPrimaryTopicOf PRKAR2B.