Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/PIK3C2B> ?p ?o }
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- PIK3C2B abstract "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.".
- PIK3C2B entrezgene "5287".
- PIK3C2B wikiPageID "14769034".
- PIK3C2B wikiPageLength "8421".
- PIK3C2B wikiPageOutDegree "3".
- PIK3C2B wikiPageRevisionID "679003171".
- PIK3C2B wikiPageWikiLink Cell_migration.
- PIK3C2B wikiPageWikiLink Enzyme.
- PIK3C2B wikiPageWikiLink Gene.
- PIK3C2B wikiPageWikiLinkText "PIK3C2B".
- PIK3C2B hasPhotoCollection PIK3C2B.
- PIK3C2B requireManualInspection "no".
- PIK3C2B summaryText "The protein encoded by this gene belongs to the phosphoinositide 3-kinase family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.".
- PIK3C2B updateCitations "yes".
- PIK3C2B updatePage "yes".
- PIK3C2B updateProteinBox "yes".
- PIK3C2B updateSummary "yes".
- PIK3C2B wikiPageUsesTemplate Template:Gene-1-stub.
- PIK3C2B wikiPageUsesTemplate Template:PBB.
- PIK3C2B wikiPageUsesTemplate Template:PBB_Controls.
- PIK3C2B wikiPageUsesTemplate Template:PBB_Further_reading.
- PIK3C2B wikiPageUsesTemplate Template:PBB_Summary.
- PIK3C2B wikiPageUsesTemplate Template:Refbegin.
- PIK3C2B wikiPageUsesTemplate Template:Refend.
- PIK3C2B wikiPageUsesTemplate Template:Reflist.
- PIK3C2B wikiPageUsesTemplate Template:Underlinked.
- PIK3C2B hypernym Enzyme.
- PIK3C2B type Biomolecule.
- PIK3C2B type Protein.
- PIK3C2B type Thing.
- PIK3C2B type Q206229.
- PIK3C2B type Q8054.
- PIK3C2B comment "Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.".
- PIK3C2B label "PIK3C2B".
- PIK3C2B sameAs m.03gxbzj.
- PIK3C2B sameAs Q7119380.
- PIK3C2B sameAs Q7119380.
- PIK3C2B wasDerivedFrom PIK3C2B?oldid=679003171.
- PIK3C2B isPrimaryTopicOf PIK3C2B.