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- PF-04457845 abstract "PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis, but was found to be ineffective.".
- PF-04457845 atcPrefix "None".
- PF-04457845 iupacName "N-pyridazin-3-yl-4-[(3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl)methylidene]piperidine-1-carboxamide".
- PF-04457845 pubchem "24771824".
- PF-04457845 thumbnail PF-04457845_structure.png?width=300.
- PF-04457845 wikiPageID "35894748".
- PF-04457845 wikiPageLength "4628".
- PF-04457845 wikiPageOutDegree "10".
- PF-04457845 wikiPageRevisionID "679450416".
- PF-04457845 wikiPageWikiLink 4-Nonylphenylboronic_acid.
- PF-04457845 wikiPageWikiLink Analgesic.
- PF-04457845 wikiPageWikiLink Anti-inflammatory.
- PF-04457845 wikiPageWikiLink Antiinflammatory.
- PF-04457845 wikiPageWikiLink Category:Enzyme_inhibitors.
- PF-04457845 wikiPageWikiLink Fatty_acid_amide_hydrolase.
- PF-04457845 wikiPageWikiLink Investigational_New_Drug.
- PF-04457845 wikiPageWikiLink LY-2183240.
- PF-04457845 wikiPageWikiLink Naproxen.
- PF-04457845 wikiPageWikiLink Osteoarthritis.
- PF-04457845 wikiPageWikiLink URB-597.
- PF-04457845 wikiPageWikiLink URB597.
- PF-04457845 wikiPageWikiLinkText "PF-04457845".
- PF-04457845 atcPrefix "None".
- PF-04457845 c "23".
- PF-04457845 chembl "1651534".
- PF-04457845 chemspiderid "26390839".
- PF-04457845 f "3".
- PF-04457845 h "20".
- PF-04457845 hasPhotoCollection PF-04457845.
- PF-04457845 inchi "1".
- PF-04457845 inchikey "BATCTBJIJJEPHM-UHFFFAOYAS".
- PF-04457845 iupacName "N-pyridazin-3-yl-4-[methylidene]piperidine-1-carboxamide".
- PF-04457845 legalStatus Investigational_New_Drug.
- PF-04457845 molecularWeight "455.432".
- PF-04457845 n "5".
- PF-04457845 o "2".
- PF-04457845 pubchem "24771824".
- PF-04457845 smiles "n4ncccc4NCNCC\C3=C/c2ccOcncc1CF".
- PF-04457845 stdinchi "1".
- PF-04457845 stdinchikey "BATCTBJIJJEPHM-UHFFFAOYSA-N".
- PF-04457845 width "280".
- PF-04457845 wikiPageUsesTemplate Template:Cannabinoids.
- PF-04457845 wikiPageUsesTemplate Template:Drugbox.
- PF-04457845 wikiPageUsesTemplate Template:Reflist.
- PF-04457845 subject Category:Enzyme_inhibitors.
- PF-04457845 type Article.
- PF-04457845 type ChemicalSubstance.
- PF-04457845 type Drug.
- PF-04457845 type Article.
- PF-04457845 type Chemical.
- PF-04457845 type Drug.
- PF-04457845 type Inhibitor.
- PF-04457845 type ChemicalObject.
- PF-04457845 type Thing.
- PF-04457845 type Q8386.
- PF-04457845 comment "PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis, but was found to be ineffective.".
- PF-04457845 label "PF-04457845".
- PF-04457845 sameAs m.0jwt31l.
- PF-04457845 sameAs PF-04457845.
- PF-04457845 sameAs PF-04457845.
- PF-04457845 sameAs Q7119045.
- PF-04457845 sameAs Q7119045.
- PF-04457845 wasDerivedFrom PF-04457845?oldid=679450416.
- PF-04457845 depiction PF-04457845_structure.png.
- PF-04457845 isPrimaryTopicOf PF-04457845.