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- PB-22 abstract "PB-22 (QUPIC or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. The structure of PB-22 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs. PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3-3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable 6 hours after dosing. One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.".
- PB-22 casNumber "1400742-17-7".
- PB-22 iupacName "1-Pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester".
- PB-22 thumbnail PB-22.png?width=300.
- PB-22 wikiPageID "38911500".
- PB-22 wikiPageLength "7312".
- PB-22 wikiPageOutDegree "21".
- PB-22 wikiPageRevisionID "683540818".
- PB-22 wikiPageWikiLink 5F-PB-22.
- PB-22 wikiPageWikiLink AM-2201.
- PB-22 wikiPageWikiLink APICA_(synthetic_cannabinoid_drug).
- PB-22 wikiPageWikiLink Anlage_II.
- PB-22 wikiPageWikiLink Category:Cannabinoids.
- PB-22 wikiPageWikiLink Category:Designer_drugs.
- PB-22 wikiPageWikiLink Category:Indoles.
- PB-22 wikiPageWikiLink Controlled_Substances_Act.
- PB-22 wikiPageWikiLink Designer_drug.
- PB-22 wikiPageWikiLink Drugs_controlled_by_the_German_Betäubungsmittelgesetz.
- PB-22 wikiPageWikiLink JWH-018.
- PB-22 wikiPageWikiLink Ohio.
- PB-22 wikiPageWikiLink QUCHIC.
- PB-22 wikiPageWikiLink Reaction_Motors_XLR11.
- PB-22 wikiPageWikiLink STS-135_(drug).
- PB-22 wikiPageWikiLink Schedule_I_controlled_substance.
- PB-22 wikiPageWikiLink Structural_analog.
- PB-22 wikiPageWikiLink Structure-activity_relationship.
- PB-22 wikiPageWikiLink Structure–activity_relationship.
- PB-22 wikiPageWikiLink Synthetic_cannabis.
- PB-22 wikiPageWikiLink UR-144.
- PB-22 wikiPageWikiLink XLR-11.
- PB-22 wikiPageWikiLinkText "PB-22".
- PB-22 c "23".
- PB-22 casNumber "1400742".
- PB-22 chemspiderid "29339966".
- PB-22 h "22".
- PB-22 hasPhotoCollection PB-22.
- PB-22 inchi "1".
- PB-22 inchikey "ZAVGICCEAOUWFM-UHFFFAOYAI".
- PB-22 iupacName "1".
- PB-22 legalStatus "Schedule I".
- PB-22 molecularWeight "358.43".
- PB-22 n "2".
- PB-22 o "2".
- PB-22 smiles "CCCCCN1C=CCOC3=CC=CC4=C3N=CC=C4".
- PB-22 stdinchi "1".
- PB-22 stdinchikey "ZAVGICCEAOUWFM-UHFFFAOYSA-N".
- PB-22 width "200".
- PB-22 wikiPageUsesTemplate Template:Cannabinoid-stub.
- PB-22 wikiPageUsesTemplate Template:Cannabinoids.
- PB-22 wikiPageUsesTemplate Template:Citation_needed.
- PB-22 wikiPageUsesTemplate Template:Drugbox.
- PB-22 wikiPageUsesTemplate Template:Or-inline.
- PB-22 wikiPageUsesTemplate Template:Reflist.
- PB-22 subject Category:Cannabinoids.
- PB-22 subject Category:Designer_drugs.
- PB-22 subject Category:Indoles.
- PB-22 hypernym Drug.
- PB-22 type ChemicalSubstance.
- PB-22 type Drug.
- PB-22 type ChemicalObject.
- PB-22 type Thing.
- PB-22 type Q8386.
- PB-22 comment "PB-22 (QUPIC or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. The structure of PB-22 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.".
- PB-22 label "PB-22".
- PB-22 sameAs m.0s8tlv4.
- PB-22 sameAs Q15708309.
- PB-22 sameAs Q15708309.
- PB-22 wasDerivedFrom PB-22?oldid=683540818.
- PB-22 depiction PB-22.png.
- PB-22 isPrimaryTopicOf PB-22.