Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/P73> ?p ?o }
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- P73 abstract "p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis. Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variants, and an alternative promoter in the DNA sequence.p73, also known as tumor protein 73 (TP73), protein was the first identified homologue of the tumor suppressor gene, p53. Like p53, p73 has several variants. It is expressed as distinct forms differing at either at the C- or the N-terminus. Currently, six different C-terminus splicing variants have been found in normal cells. The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53.The p73 gene has been mapped to a chromosome region (1p36. 2-3) a locus commonly deleted in various tumor entities and human cancers. Similar to p53 the protein product of p73 induces cell cycle arrest or apoptosis, hence its classification as a tumor suppressor. However unlike its counterpart, p73 is infrequently mutated in cancers. Perhaps, even more shocking is the fact that p73 – deficient mice do not show a tumorigenic phenotype. A deficiency of p53 almost certainly leads to unchecked cell proliferation and is noted in 60% of cancers. Analyses of many tumors typically found in humans including breast and ovarian cancer show a high expression of p73 when compared to normal tissues in corresponding areas. Adenoviruses that cause cellular transformations have also been found to result in increased p73 expression. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. Many researchers believe that these results imply that p73 may not be a tumor suppressor but rather an oncoprotein. Some suggest that the TP73 locus encodes both a tumor suppressor (TAp73) and a putative oncogene (ΔNp73). This is a strong theory and causes much confusion, as it is unknown which of the two p73 variants is over-expressed and ultimately plays a role in tumorigenesis.Genes of the p53 family are known to be complex. The viral oncoproteins (e.g. Adenovirus E1B) that efficiently inhibit p53 function are unable to inactivate p73, and those that seem to inhibit p73 have no effect on p53.Debate persists about the exact function of p73. Recently it has been reported that p73 is enriched in the nervous system and that the p73-deficient mice, which do not exhibit an increased susceptibility to spontaneous tumorigenesis, have neurological and immunological defects. These results have been expanded and it has also been shown that p73 is present in early stages of neurological development and neuronal apoptosis by blocking the proapoptotic function of p53. This strongly implicates p73 as playing a large role in cellular differentiation.".
- P73 entrezgene "7161".
- P73 wikiPageExternalLink pmidlookup?view=long&pmid=10769197.
- P73 wikiPageExternalLink S0092-8674(00)80540-1.
- P73 wikiPageExternalLink j.1349-7006.2003.tb01508.x.
- P73 wikiPageExternalLink pmidlookup?view=long&pmid=10894779.
- P73 wikiPageID "2235737".
- P73 wikiPageLength "8141".
- P73 wikiPageOutDegree "9".
- P73 wikiPageRevisionID "679000928".
- P73 wikiPageWikiLink Alternative_splicing.
- P73 wikiPageWikiLink Apoptosis.
- P73 wikiPageWikiLink Category:Proteins.
- P73 wikiPageWikiLink Category:Tumor_suppressor_genes.
- P73 wikiPageWikiLink Cell_cycle.
- P73 wikiPageWikiLink DNA.
- P73 wikiPageWikiLink P53.
- P73 wikiPageWikiLink Promoter_(biology).
- P73 wikiPageWikiLink Promoter_(genetics).
- P73 wikiPageWikiLink Splice_variant.
- P73 wikiPageWikiLink Tumor_suppressor_gene.
- P73 wikiPageWikiLinkText "P73".
- P73 wikiPageWikiLinkText "p73".
- P73 hasPhotoCollection P73.
- P73 requireManualInspection "no".
- P73 updateCitations "yes".
- P73 updatePage "yes".
- P73 updateProteinBox "yes".
- P73 updateSummary "no".
- P73 wikiPageUsesTemplate Template:Cell_cycle_proteins.
- P73 wikiPageUsesTemplate Template:Cite_journal.
- P73 wikiPageUsesTemplate Template:Lowercase.
- P73 wikiPageUsesTemplate Template:MeshName.
- P73 wikiPageUsesTemplate Template:PBB.
- P73 wikiPageUsesTemplate Template:PBB_Controls.
- P73 wikiPageUsesTemplate Template:PBB_Further_reading.
- P73 wikiPageUsesTemplate Template:PDB_Gallery.
- P73 wikiPageUsesTemplate Template:Refbegin.
- P73 wikiPageUsesTemplate Template:Refend.
- P73 wikiPageUsesTemplate Template:Tumor_suppressor_genes.
- P73 subject Category:Proteins.
- P73 subject Category:Tumor_suppressor_genes.
- P73 hypernym Protein.
- P73 type Biomolecule.
- P73 type Protein.
- P73 type Biomolecule.
- P73 type Nutrient.
- P73 type Process.
- P73 type Thing.
- P73 type Q206229.
- P73 type Q8054.
- P73 comment "p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis. Like p53, p73 is characterized by the presence of different isoforms of the protein.".
- P73 label "P73".
- P73 sameAs P73.
- P73 sameAs P73.
- P73 sameAs m.06y4x4.
- P73 sameAs P73_(وراثہ).
- P73 sameAs Q4197146.
- P73 sameAs Q4197146.
- P73 wasDerivedFrom P73?oldid=679000928.
- P73 isPrimaryTopicOf P73.