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- P110δ abstract "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene.p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is considered to be a promising target for drugs that aim to prevent or treat inflammation and autoimmunity and transplant rejection.Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110α, p110β, and p110γ. p110α and p110β interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.".
- P110δ entrezgene "5293".
- P110δ wikiPageID "3873667".
- P110δ wikiPageLength "18211".
- P110δ wikiPageOutDegree "56".
- P110δ wikiPageRevisionID "679000712".
- P110δ wikiPageWikiLink AKT.
- P110δ wikiPageWikiLink Activated_PI3K_Delta_Syndrome.
- P110δ wikiPageWikiLink Akt.
- P110δ wikiPageWikiLink Allergy.
- P110δ wikiPageWikiLink Antibody.
- P110δ wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- P110δ wikiPageWikiLink B_cell.
- P110δ wikiPageWikiLink CAL-101.
- P110δ wikiPageWikiLink CD278.
- P110δ wikiPageWikiLink CD28.
- P110δ wikiPageWikiLink Category:EC_2.7.1.
- P110δ wikiPageWikiLink Category:Immune_system.
- P110δ wikiPageWikiLink Chronic_lymphocytic_leukemia.
- P110δ wikiPageWikiLink Enzyme.
- P110δ wikiPageWikiLink Gene.
- P110δ wikiPageWikiLink Gilead_Sciences.
- P110δ wikiPageWikiLink IC87114.
- P110δ wikiPageWikiLink ICOS.
- P110δ wikiPageWikiLink Icos.
- P110δ wikiPageWikiLink Idelalisib.
- P110δ wikiPageWikiLink Interleukin_2.
- P110δ wikiPageWikiLink Leukocytes.
- P110δ wikiPageWikiLink Mast_cell.
- P110δ wikiPageWikiLink Mast_cells.
- P110δ wikiPageWikiLink Neutrophil.
- P110δ wikiPageWikiLink Neutrophil_granulocyte.
- P110δ wikiPageWikiLink Neutrophils.
- P110δ wikiPageWikiLink P110α.
- P110δ wikiPageWikiLink P110γ.
- P110δ wikiPageWikiLink P85α.
- P110δ wikiPageWikiLink P85β.
- P110δ wikiPageWikiLink PASLI_disease.
- P110δ wikiPageWikiLink PIK3CB.
- P110δ wikiPageWikiLink PIK3CG.
- P110δ wikiPageWikiLink PIK3R1.
- P110δ wikiPageWikiLink PIK3R2.
- P110δ wikiPageWikiLink Peritoneum.
- P110δ wikiPageWikiLink Phosphatidylinositol_(3,4,5)-trisphosphate.
- P110δ wikiPageWikiLink Phosphatidylinositol_4,5-bisphosphate.
- P110δ wikiPageWikiLink Phosphoinositide_3-kinase.
- P110δ wikiPageWikiLink Phosphoinositide_3-kinase_inhibitor.
- P110δ wikiPageWikiLink Placebo.
- P110δ wikiPageWikiLink Protein-protein_interaction.
- P110δ wikiPageWikiLink Protein_kinase_B.
- P110δ wikiPageWikiLink Protein–protein_interaction.
- P110δ wikiPageWikiLink PtdIns(3,4,5)P3.
- P110δ wikiPageWikiLink PtdIns(4,5)P2.
- P110δ wikiPageWikiLink Ras_subfamily.
- P110δ wikiPageWikiLink Reactive_oxygen_species.
- P110δ wikiPageWikiLink Rituximab.
- P110δ wikiPageWikiLink SH2_domain.
- P110δ wikiPageWikiLink SH3_domain.
- P110δ wikiPageWikiLink TEC_(gene).
- P110δ wikiPageWikiLink T_cell.
- P110δ wikiPageWikiLink T_cells.
- P110δ wikiPageWikiLink Tyrosine.
- P110δ wikiPageWikiLink Tyrosine_kinase.
- P110δ wikiPageWikiLink White_blood_cell.
- P110δ wikiPageWikiLink Zydelig.
- P110δ wikiPageWikiLinkText "P110%CE%B4".
- P110δ wikiPageWikiLinkText "P110δ".
- P110δ wikiPageWikiLinkText "PI3Kinase delta".
- P110δ wikiPageWikiLinkText "PIK3CD".
- P110δ wikiPageWikiLinkText "p110 delta".
- P110δ wikiPageWikiLinkText "p110δ".
- P110δ colwidth "35".
- P110δ hasPhotoCollection P110δ.
- P110δ wikiPageUsesTemplate Template:Cite_journal.
- P110δ wikiPageUsesTemplate Template:PBB.
- P110δ wikiPageUsesTemplate Template:Refbegin.
- P110δ wikiPageUsesTemplate Template:Refend.
- P110δ wikiPageUsesTemplate Template:Reflist.
- P110δ subject Category:EC_2.7.1.
- P110δ subject Category:Immune_system.
- P110δ type Biomolecule.
- P110δ type Protein.
- P110δ type Thing.
- P110δ type Q206229.
- P110δ type Q8054.
- P110δ comment "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene.p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells).".
- P110δ label "P110δ".
- P110δ sameAs m.0b4dyn.
- P110δ sameAs Q7117825.
- P110δ sameAs Q7117825.
- P110δ wasDerivedFrom P110δ?oldid=679000712.
- P110δ isPrimaryTopicOf P110δ.