Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Norketamine> ?p ?o }
Showing triples 1 to 98 of
98
with 100 triples per page.
- Norketamine abstract "Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist (Ki = 1.7 µM and 13 µM for (S)-(+)-norketamine and (R)-(–)-norketamine, respectively), but is about 3–5 times less potent as an anesthetic in comparison. Also, similarly again to ketamine, norketamine binds to the μ- and κ-opioid receptors. Relative to ketamine, norketamine is much more potent as an antagonist of the α7-nicotinic acetylcholine receptor, and produces rapid antidepressant effects in animal models which have been reported to correlate with its activity at this receptor. However, norketamine is about 1/5th as potent as ketamine as an antidepressant in mice as per the forced swim test, and this seems also to be in accordance with its 3–5-fold reduced comparative potency in vivo as an NMDA receptor antagonist. Norketamine is metabolized into dehydronorketamine, which is far less active as an NMDA receptor antagonist in comparison but retains activity as a potent antagonist of the α7-nicotinic acetylcholine receptor.".
- Norketamine atcPrefix "None".
- Norketamine casNumber "35211-10-0".
- Norketamine casSupplemental "79499-59-5 (HCl)".
- Norketamine iupacName "2-Amino-2-(2-chlorophenyl)cyclohexan-1-one".
- Norketamine pubchem "123767".
- Norketamine thumbnail Norketamine.svg?width=300.
- Norketamine wikiPageID "46935927".
- Norketamine wikiPageLength "6647".
- Norketamine wikiPageOutDegree "30".
- Norketamine wikiPageRevisionID "676142032".
- Norketamine wikiPageWikiLink Active_metabolite.
- Norketamine wikiPageWikiLink Alpha-7_nicotinic_receptor.
- Norketamine wikiPageWikiLink Anesthetic.
- Norketamine wikiPageWikiLink Animal_model.
- Norketamine wikiPageWikiLink Antidepressant.
- Norketamine wikiPageWikiLink Arketamine.
- Norketamine wikiPageWikiLink Behavioural_despair_test.
- Norketamine wikiPageWikiLink CYP3A4.
- Norketamine wikiPageWikiLink Category:Amines.
- Norketamine wikiPageWikiLink Category:Antidepressants.
- Norketamine wikiPageWikiLink Category:Chloroarenes.
- Norketamine wikiPageWikiLink Category:Dissociative_drugs.
- Norketamine wikiPageWikiLink Category:General_anesthetics.
- Norketamine wikiPageWikiLink Category:Kappa_agonists.
- Norketamine wikiPageWikiLink Category:Ketones.
- Norketamine wikiPageWikiLink Category:Mu-opioid_agonists.
- Norketamine wikiPageWikiLink Category:NMDA_receptor_antagonists.
- Norketamine wikiPageWikiLink Category:Nicotinic_antagonists.
- Norketamine wikiPageWikiLink Category:Sedatives.
- Norketamine wikiPageWikiLink Dehydronorketamine.
- Norketamine wikiPageWikiLink Esketamine.
- Norketamine wikiPageWikiLink Forced_swim_test.
- Norketamine wikiPageWikiLink Hydrochloride.
- Norketamine wikiPageWikiLink Hydroxynorketamine.
- Norketamine wikiPageWikiLink In_vivo.
- Norketamine wikiPageWikiLink Ketamine.
- Norketamine wikiPageWikiLink Model_organism.
- Norketamine wikiPageWikiLink NMDA_receptor_antagonist.
- Norketamine wikiPageWikiLink Noncompetitive_antagonist.
- Norketamine wikiPageWikiLink Receptor_antagonist.
- Norketamine wikiPageWikiLink Α7-nicotinic_acetylcholine_receptor.
- Norketamine wikiPageWikiLink Κ-opioid_receptor.
- Norketamine wikiPageWikiLink Μ-opioid_receptor.
- Norketamine wikiPageWikiLinkText "Norketamine".
- Norketamine wikiPageWikiLinkText "norketamine".
- Norketamine atcPrefix "None".
- Norketamine c "12".
- Norketamine casNumber "35211".
- Norketamine casSupplemental "79499".
- Norketamine chemspiderid "110322".
- Norketamine cl "1".
- Norketamine h "14".
- Norketamine hasPhotoCollection Norketamine.
- Norketamine inchi "InChI=1S/C12H14ClNO/c13-10-6-2-1-5-9128-4-3-7-1115/h1-2,5-6H,3-4,7-8,14H2".
- Norketamine inchikey "BEQZHFIKTBVCAU-UHFFFAOYSA-N".
- Norketamine iupacName "2".
- Norketamine molecularWeight "223.69866".
- Norketamine n "1".
- Norketamine o "1".
- Norketamine pubchem "123767".
- Norketamine smiles "C1CCCN".
- Norketamine width "200".
- Norketamine wikiPageUsesTemplate Template:Antidepressants.
- Norketamine wikiPageUsesTemplate Template:Cholinergics.
- Norketamine wikiPageUsesTemplate Template:Drugbox.
- Norketamine wikiPageUsesTemplate Template:General_anesthetics.
- Norketamine wikiPageUsesTemplate Template:Glutamatergics.
- Norketamine wikiPageUsesTemplate Template:Hallucinogens.
- Norketamine wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Norketamine wikiPageUsesTemplate Template:Opioidergics.
- Norketamine wikiPageUsesTemplate Template:Reflist.
- Norketamine subject Category:Amines.
- Norketamine subject Category:Antidepressants.
- Norketamine subject Category:Chloroarenes.
- Norketamine subject Category:Dissociative_drugs.
- Norketamine subject Category:General_anesthetics.
- Norketamine subject Category:Kappa_agonists.
- Norketamine subject Category:Ketones.
- Norketamine subject Category:Mu-opioid_agonists.
- Norketamine subject Category:NMDA_receptor_antagonists.
- Norketamine subject Category:Nicotinic_antagonists.
- Norketamine subject Category:Sedatives.
- Norketamine hypernym Metabolite.
- Norketamine type ChemicalCompound.
- Norketamine type ChemicalSubstance.
- Norketamine type Drug.
- Norketamine type ChemicalObject.
- Norketamine type Thing.
- Norketamine type Q8386.
- Norketamine comment "Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist (Ki = 1.7 µM and 13 µM for (S)-(+)-norketamine and (R)-(–)-norketamine, respectively), but is about 3–5 times less potent as an anesthetic in comparison. Also, similarly again to ketamine, norketamine binds to the μ- and κ-opioid receptors.".
- Norketamine label "Norketamine".
- Norketamine sameAs m.013dbvkq.
- Norketamine sameAs Q20164391.
- Norketamine sameAs Q20164391.
- Norketamine wasDerivedFrom Norketamine?oldid=676142032.
- Norketamine depiction Norketamine.svg.
- Norketamine isPrimaryTopicOf Norketamine.