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- Nitrophorin abstract "Nitrophorins are hemoproteins found in the saliva of blood-feeding insects. Saliva of the blood-sucking bug Rhodnius prolixus contains at least seven homologous nitrophorins, designated NP1 to NP7 in order of their relative abundance in the glands. As isolated, nitrophorins contain nitric oxide (NO) ligated to the ferric heme iron (Fe3+). Histamine, which is released by the host in response to tissue damage, is another nitrophorin ligand. Nitrophorins transport NO to the feeding site. Dilution, binding of histamine and increase in pH (from pH ~5 in salivary gland to pH ~7.4 in the host tissue) facilitate the release of NO into the tissue where it induces vasodilatation. The salivary nitrophorin from the hemipteran Cimex lectularius (bedbug) has no sequence similarity to Rhodnius prolixus nitrophorins but is homologous to the inositol-polyphosphate 5-phosphatase (EC 3.1.3.56). It is suggested that the two classes of insect nitrophorins have arisen as a product of the convergent evolution.The crystal structures of several nitrophorin complexes are known. The Rhodnius prolixus nitrophorin structures reveal lipocalin-like eight-stranded β-barrel, three α-helices and two disulfide bonds, with heme inserted into one end of the barrel. Members of the lipocalin family are known to bind a variety of small hydrophobic ligands, including biliverdin, in a similar fashion. The heme iron is ligated to histidine residue (His-59). The position of His-59 is restrained through water-mediated hydrogen bond to the carboxylate of aspartic acid residue (Asp-70). The His-59–Fe bond is bent ~15° out of the imidazole plane. Asp-70 forms an unusual hydrogen bond with one of the heme propionates, suggesting the residuehas an altered pKa. In NP1-histamine structure, the planes of His-59 and histamine imidazole rings lie in an arrangement almost identical to that found in oxidized cytochrome b5.The fold of nitrophorin from Cimex lectularius consists of central 11-stranded β-sandwich and seven peripheral α-helices. The heme is positioned between β-sheet and an α-helix, with heme iron ligated to cysteinate residue. NO can bind both to heme Fe3+ and to proximal Cys-60 ligand causing reversible S-nitrosylation.".
- Nitrophorin wikiPageExternalLink search.cgi?key=lipocalins.
- Nitrophorin wikiPageExternalLink np.htm.
- Nitrophorin wikiPageID "1985028".
- Nitrophorin wikiPageLength "3919".
- Nitrophorin wikiPageOutDegree "20".
- Nitrophorin wikiPageRevisionID "675799469".
- Nitrophorin wikiPageWikiLink Acid_dissociation_constant.
- Nitrophorin wikiPageWikiLink Aspartic_acid.
- Nitrophorin wikiPageWikiLink Bed_bug.
- Nitrophorin wikiPageWikiLink Bedbug.
- Nitrophorin wikiPageWikiLink Biliverdin.
- Nitrophorin wikiPageWikiLink Category:Hemoproteins.
- Nitrophorin wikiPageWikiLink Convergent_evolution.
- Nitrophorin wikiPageWikiLink Hematophagy.
- Nitrophorin wikiPageWikiLink Hemeprotein.
- Nitrophorin wikiPageWikiLink Hemiptera.
- Nitrophorin wikiPageWikiLink Hemoprotein.
- Nitrophorin wikiPageWikiLink Histamine.
- Nitrophorin wikiPageWikiLink Histidine.
- Nitrophorin wikiPageWikiLink Host_(biology).
- Nitrophorin wikiPageWikiLink Hydrogen_bond.
- Nitrophorin wikiPageWikiLink Iron.
- Nitrophorin wikiPageWikiLink Lipocalin.
- Nitrophorin wikiPageWikiLink Nitric_oxide.
- Nitrophorin wikiPageWikiLink PH.
- Nitrophorin wikiPageWikiLink Rhodnius_prolixus.
- Nitrophorin wikiPageWikiLink Saliva.
- Nitrophorin wikiPageWikiLink Vasodilation.
- Nitrophorin wikiPageWikiLink Vasodilator.
- Nitrophorin wikiPageWikiLinkText "Nitrophorin".
- Nitrophorin hasPhotoCollection Nitrophorin.
- Nitrophorin wikiPageUsesTemplate Template:Cite_journal.
- Nitrophorin wikiPageUsesTemplate Template:EC_number.
- Nitrophorin wikiPageUsesTemplate Template:PDB.
- Nitrophorin subject Category:Hemoproteins.
- Nitrophorin hypernym Hemoproteins.
- Nitrophorin type Protein.
- Nitrophorin type Metalloprotein.
- Nitrophorin comment "Nitrophorins are hemoproteins found in the saliva of blood-feeding insects. Saliva of the blood-sucking bug Rhodnius prolixus contains at least seven homologous nitrophorins, designated NP1 to NP7 in order of their relative abundance in the glands. As isolated, nitrophorins contain nitric oxide (NO) ligated to the ferric heme iron (Fe3+). Histamine, which is released by the host in response to tissue damage, is another nitrophorin ligand. Nitrophorins transport NO to the feeding site.".
- Nitrophorin label "Nitrophorin".
- Nitrophorin sameAs m.06bzmc.
- Nitrophorin sameAs Q7041499.
- Nitrophorin sameAs Q7041499.
- Nitrophorin wasDerivedFrom Nitrophorin?oldid=675799469.
- Nitrophorin isPrimaryTopicOf Nitrophorin.