Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Nilutamide> ?p ?o }
- Nilutamide abstract "Nilutamide (INN, USAN, BAN) (brand names Nilandron (US), Anandron (CA)) is a synthetic, non-steroidal, pure antiandrogen used in the treatment of advanced-stage (metastatic) prostate cancer. It was developed by Roussel, introduced in 1987, and was the second non-steroidal antiandrogen to be marketed after flutamide. Nilutamide acts as a potent and selective competitive silent antagonist of the androgen receptor (AR), which prevents testosterone and other androgens from activating the AR. Because most prostate cancer cells rely on activation of the AR for growth and survival, nilutamide can extend life in men with prostate cancer.Nilutamide is used in prostate cancer in combination with a GnRH analogue at a dosage of 300 mg daily for the first 4 weeks of treatment, and 150 mg once daily thereafter. It is not indicated as a monotherapy in prostate cancer. Nilutamide has a half-life of approximately two days, which allows for once-daily administration. In addition to prostate cancer, nilutamide has also been studied in and used as a component of hormone replacement therapy in trans women.General side effects of non-steroidal antiandrogens, including nilutamide, include gynecomastia, breast pain/tenderness, hot flashes, depression, fatigue, and sexual dysfunction. In addition, relative to other non-steroidal antiandrogens, nilutamide has been uniquely associated with mild and reversible visual disturbances (31%), a disulfiram-like alcohol intolerance (19%), and interstitial pneumonitis (1–2%) (which can progress to pulmonary fibrosis), and has a higher incidence of nausea (27%) and vomiting than other non-steroidal antiandrogens. There is also a risk of hepatoxicity with nilutamide, though occurrence is very rare and the risk is significantly less than with flutamide. The unique adverse effects of nilutamide, and especially its risk of interstitial pneumonitis, have limited its clinical use relative to other non-steroidal antiandrogens. From a safety standpoint, bicalutamide is clinically preferred over both nilutamide (due to interstitial pneumonitis) and flutamide (due to hepatotoxicity) in regards to choice of non-steroidal antiandrogen.Like other non-steroidal antiandrogens such as flutamide and bicalutamide, nilutamide, without concomitant GnRH analogue therapy, increases serum androgen (by two-fold in the case of testosterone), estrogen, and prolactin levels due to inhibition of AR-mediated suppression of steroidogenesis via negative feedback on the hypothalamic-pituitary-gonadal axis. As such, though nilutamide is still highly effective as an antiandrogen as a monotherapy, it is given in combination with a GnRH analogue such as leuprorelin in prostate cancer to suppress androgen concentrations to castrate levels in order to attain maximal androgen blockade (MAB).Like flutamide and bicalutamide, nilutamide is able to cross the blood-brain-barrier and has central antiandrogen actions.".
- Nilutamide atcPrefix "L02".
- Nilutamide atcSuffix "BB02".
- Nilutamide casNumber "63612-50-0".
- Nilutamide chEBI "7573".
- Nilutamide drugbank "DB00665".
- Nilutamide fdaUniiCode "51G6I8B902".
- Nilutamide iupacName "5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione".
- Nilutamide pubchem "4493".
- Nilutamide thumbnail Nilutamide.svg?width=300.
- Nilutamide wikiPageID "3374583".
- Nilutamide wikiPageLength "11361".
- Nilutamide wikiPageOutDegree "57".
- Nilutamide wikiPageRevisionID "678717983".
- Nilutamide wikiPageWikiLink Abiraterone_acetate.
- Nilutamide wikiPageWikiLink Adverse_effect.
- Nilutamide wikiPageWikiLink Androgen.
- Nilutamide wikiPageWikiLink Androgen_receptor.
- Nilutamide wikiPageWikiLink Antiandrogen.
- Nilutamide wikiPageWikiLink Bicalutamide.
- Nilutamide wikiPageWikiLink Blood-brain-barrier.
- Nilutamide wikiPageWikiLink Blood–brain_barrier.
- Nilutamide wikiPageWikiLink Breast_pain.
- Nilutamide wikiPageWikiLink British_Approved_Name.
- Nilutamide wikiPageWikiLink Canada.
- Nilutamide wikiPageWikiLink Category:Antiandrogens.
- Nilutamide wikiPageWikiLink Category:Hydantoins.
- Nilutamide wikiPageWikiLink Category:Nitrobenzenes.
- Nilutamide wikiPageWikiLink Category:Organofluorides.
- Nilutamide wikiPageWikiLink Central_nervous_system.
- Nilutamide wikiPageWikiLink Combination_therapy.
- Nilutamide wikiPageWikiLink Competitive_antagonist.
- Nilutamide wikiPageWikiLink Cyproterone_acetate.
- Nilutamide wikiPageWikiLink Depression_(mood).
- Nilutamide wikiPageWikiLink Disulfiram.
- Nilutamide wikiPageWikiLink Drinking_alcohol.
- Nilutamide wikiPageWikiLink Drug_intolerance.
- Nilutamide wikiPageWikiLink Enzalutamide.
- Nilutamide wikiPageWikiLink Estrogen.
- Nilutamide wikiPageWikiLink Ethanol.
- Nilutamide wikiPageWikiLink Fatigue_(medical).
- Nilutamide wikiPageWikiLink Flutamide.
- Nilutamide wikiPageWikiLink GnRH_analogue.
- Nilutamide wikiPageWikiLink Gonadotropin-releasing_hormone_analogue.
- Nilutamide wikiPageWikiLink Gynecomastia.
- Nilutamide wikiPageWikiLink Half-life.
- Nilutamide wikiPageWikiLink Hepatotoxicity.
- Nilutamide wikiPageWikiLink Hepatoxicity.
- Nilutamide wikiPageWikiLink Hormone_replacement_therapy_(male-to-female).
- Nilutamide wikiPageWikiLink Hot_flash.
- Nilutamide wikiPageWikiLink Hypothalamic-pituitary-gonadal_axis.
- Nilutamide wikiPageWikiLink Hypothalamic–pituitary–gonadal_axis.
- Nilutamide wikiPageWikiLink International_Nonproprietary_Name.
- Nilutamide wikiPageWikiLink Interstitial_lung_disease.
- Nilutamide wikiPageWikiLink Interstitial_pneumonitis.
- Nilutamide wikiPageWikiLink Leuprorelin.
- Nilutamide wikiPageWikiLink Mastodynia.
- Nilutamide wikiPageWikiLink Maximum_androgen_blockade.
- Nilutamide wikiPageWikiLink Metastasis.
- Nilutamide wikiPageWikiLink Metastatic.
- Nilutamide wikiPageWikiLink Monotherapy.
- Nilutamide wikiPageWikiLink Mouth.
- Nilutamide wikiPageWikiLink Nausea.
- Nilutamide wikiPageWikiLink Negative_feedback.
- Nilutamide wikiPageWikiLink Non-steroidal.
- Nilutamide wikiPageWikiLink Nonsteroidal.
- Nilutamide wikiPageWikiLink Organic_compound.
- Nilutamide wikiPageWikiLink Prolactin.
- Nilutamide wikiPageWikiLink Prostate_cancer.
- Nilutamide wikiPageWikiLink Pulmonary_fibrosis.
- Nilutamide wikiPageWikiLink Receptor_antagonist.
- Nilutamide wikiPageWikiLink Roussel_Uclaf.
- Nilutamide wikiPageWikiLink Sexual_dysfunction.
- Nilutamide wikiPageWikiLink Side_effect.
- Nilutamide wikiPageWikiLink Silent_antagonist.
- Nilutamide wikiPageWikiLink Steroid.
- Nilutamide wikiPageWikiLink Steroidogenesis.
- Nilutamide wikiPageWikiLink Testosterone.
- Nilutamide wikiPageWikiLink Trans_woman.
- Nilutamide wikiPageWikiLink Trans_women.
- Nilutamide wikiPageWikiLink United_States.
- Nilutamide wikiPageWikiLink United_States_Adopted_Name.
- Nilutamide wikiPageWikiLink Vision_disorder.
- Nilutamide wikiPageWikiLink Visual_disturbance.
- Nilutamide wikiPageWikiLink Vomiting.
- Nilutamide wikiPageWikiLinkText "Nilutamide".
- Nilutamide wikiPageWikiLinkText "nilutamide".
- Nilutamide atcPrefix "L02".
- Nilutamide atcSuffix "BB02".
- Nilutamide c "12".
- Nilutamide casNumber "63612".
- Nilutamide chebi "7573".
- Nilutamide chembl "1274".
- Nilutamide chemspiderid "4337".
- Nilutamide drugbank "DB00665".
- Nilutamide eliminationHalfLife "201600.0".
- Nilutamide f "3".
- Nilutamide h "10".
- Nilutamide hasPhotoCollection Nilutamide.
- Nilutamide inchi "1".