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- Nick_(DNA) abstract "A nick is a discontinuity in a double stranded DNA molecule where there is no phosphodiester bond between adjacent nucleotides of one strand typically through damage or enzyme action. Nicks allow for the much-needed release of torsion in the strand during DNA replication. Nicks are also thought to play a role in the DNA mismatch repair mechanisms that fix errors on both the leading and lagging daughter strands. The nicks act as recognizable markers to help the repair machinery distinguish the newly synthesized strand (daughter strand) from the template strand (parental strand). However, the mechanism between the leading and lagging strand differs. On the lagging strand, nicks exist between Okazaki fragments and are easily recognizable by the DNA mismatch repair machinery prior to ligation. Due to the continuous replication that occurs on the leading strand, the mechanism there is slightly more complex. During replication, ribonucleotides are added by replication enzymes and these ribonucleotides are nicked by an enzyme called RNase H2. Together, the presence of a nick and a ribonucleotide make the leading strand easily recognizable to the DNA mismatch repair machinery.".
- Nick_(DNA) wikiPageID "2892265".
- Nick_(DNA) wikiPageLength "1672".
- Nick_(DNA) wikiPageOutDegree "12".
- Nick_(DNA) wikiPageRevisionID "683420443".
- Nick_(DNA) wikiPageWikiLink Category:DNA.
- Nick_(DNA) wikiPageWikiLink DNA.
- Nick_(DNA) wikiPageWikiLink DNA_mismatch_repair.
- Nick_(DNA) wikiPageWikiLink Enzyme.
- Nick_(DNA) wikiPageWikiLink Ligation.
- Nick_(DNA) wikiPageWikiLink Nucleotide.
- Nick_(DNA) wikiPageWikiLink Okazaki_fragments.
- Nick_(DNA) wikiPageWikiLink Phosphodiester_bond.
- Nick_(DNA) wikiPageWikiLink RNASEH2A.
- Nick_(DNA) wikiPageWikiLink Ribonucleotide.
- Nick_(DNA) wikiPageWikiLinkText "Nick (DNA)".
- Nick_(DNA) wikiPageWikiLinkText "nick (DNA)".
- Nick_(DNA) wikiPageWikiLinkText "nick".
- Nick_(DNA) wikiPageWikiLinkText "nicked".
- Nick_(DNA) wikiPageWikiLinkText "nicks".
- Nick_(DNA) hasPhotoCollection Nick_(DNA).
- Nick_(DNA) wikiPageUsesTemplate Template:Genetics-stub.
- Nick_(DNA) wikiPageUsesTemplate Template:Reflist.
- Nick_(DNA) wikiPageUsesTemplate Template:Unreferenced.
- Nick_(DNA) subject Category:DNA.
- Nick_(DNA) hypernym Discontinuity.
- Nick_(DNA) type Disease.
- Nick_(DNA) comment "A nick is a discontinuity in a double stranded DNA molecule where there is no phosphodiester bond between adjacent nucleotides of one strand typically through damage or enzyme action. Nicks allow for the much-needed release of torsion in the strand during DNA replication. Nicks are also thought to play a role in the DNA mismatch repair mechanisms that fix errors on both the leading and lagging daughter strands.".
- Nick_(DNA) label "Nick (DNA)".
- Nick_(DNA) sameAs m.089m3t.
- Nick_(DNA) sameAs Q11693938.
- Nick_(DNA) sameAs Q11693938.
- Nick_(DNA) wasDerivedFrom Nick_(DNA)?oldid=683420443.
- Nick_(DNA) isPrimaryTopicOf Nick_(DNA).