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- NSAID_hypersensitivity_reactions abstract "NSAID or nonsteroidal anti-inflammatory drug hypersensitivity reactions encompasses a broad range of allergic or allergic-like symptoms that occur within minutes to hours after ingesting aspirin or other NSAID nonsteroidal anti-inflammatory drugs. Hypersensitivity drug reactions differ from drug toxicity reactions in that drug toxicity reactions result from the pharmacological action of a drug, are dose-related, and can occur in any treated individual (see nonsteroidal anti-inflammatory drugs section on adverse reactions for NSAID-induced toxic reactions); hypersensitivity reactions are idiosyncratic reactions to a drug. The broad range of hypersensitivity syndromes evoked by NSAID has recently been classified by the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity. The classification organizes the hypersensitivity reactions to NSAIDs into the following five categories: 1) NSAIDs-exacerbated respiratory disease (NERD) is an acute (immediate to several hours) exacerbation of bronchoconstriction and other symptoms of asthma (see aspirin-induced asthma) in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of rhinitis and sinusitis in individuals with a history of rhinosinusitis after ingestion of various NSAIDs, particularly those that act by inhibiting the COX-1 enzyme. NERD does not appear to be due to a true allergic reaction to NSAIDs but rather at least in part to the more direct effects of these drugs to promote the production and/or release of certain mediators of allergy. That is, inhibition of cellular COX activity deprives tissues of its anti-inflammatory product(s), particularly prostaglandin E2 while concurrently shuttling its substrate, arachidonic acid, into other metabolizing enzymes, particularly 5-lipoxygenase (ALOX5) to overproduce pro-inflammatory leukotriene and 5-Hydroxyicosatetraenoic acid metabolites and 15-lipoxygenase (ALOX15) to overproduce pro-inflammatory 15-Hydroxyicosatetraenoic acid metabolites, including eoxins; the condition is also is associated with a reduction in the anti-inflammatory metabolite, lipoxin A4, and increases in certain pro-allergic chemokines such as eotaxin-2 and CCL7. 2) NSAIDs-exacerbated cutaneous disease (NECD) is an acute exacerbation of wheals and/or angioedema in individuals with a history of chronic urticaria. NECD also appears due to the non-allergic action of NSAIDs in inhibiting the production of COX anti-inflammatory metabolites while promoting the production 5-lipoxygenase and 15-lipoxygenase pro-inflammatory metabolites and the overproduction of certain pro-allergic [[chemokines}]], e.g. eotaxin-1, eotaxin-2, RANTES, and interleukin-5. 3) NSAIDs-induced urticarial disease (NEUD) is the acute development of wheals and/or angioedema in individuals with no history of chronic NSAIDs-induced urticaria or related diseases. The mechanism behind NEUD is unknown but may be due to the non-allergic action of NSAIDs in promoting the production and/or release of allergy mediators. 4) Single NSAID-induced urticarial/angioedema or anaphylaxis (SNIUAA) is the acute development of urticarial, angioedema, or anaphylaxis in response to a single type of NSAID and/or a single group of NSAIDs with a similar structure but not to other structurally unrelated NSAIDs in individuals with no history of underlying relevant chronic diseases. SNIUAA is due to a true IgE-mediated allergy reaction. 5 Single NSAID-induced delayed reactions (SNIDR) are a set of delayed onset (usually more than 24 hour) reactions to NSAIDs. SNIDR are most commonly skin reactions that may be relatively mild moderately severe such as maculopapular rash, fixed drug eruptions, photosensitivity reactions, delayed urticaria, and contact dermatitis or extremely severe such as the DRESS syndrome, acute generalized exanthematous pustulosis, the Stevens–Johnson syndrome, and toxic epidermal necrolysis (also termed Lyell's syndrome). SNIDR result from the drug-specific stimulation of CD4+ T lymphocytes and CD8+ Cytotoxic T cells to elicit a delayed type hypersensitivity reaction.↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑".
- NSAID_hypersensitivity_reactions wikiPageID "47308555".
- NSAID_hypersensitivity_reactions wikiPageLength "5682".
- NSAID_hypersensitivity_reactions wikiPageOutDegree "50".
- NSAID_hypersensitivity_reactions wikiPageRevisionID "673255179".
- NSAID_hypersensitivity_reactions wikiPageWikiLink 15-Hydroxyicosatetraenoic_acid.
- NSAID_hypersensitivity_reactions wikiPageWikiLink 15-lipoxygenase.
- NSAID_hypersensitivity_reactions wikiPageWikiLink 5-Hydroxyicosatetraenoic_acid.
- NSAID_hypersensitivity_reactions wikiPageWikiLink 5-lipoxygenase.
- NSAID_hypersensitivity_reactions wikiPageWikiLink ALOX15.
- NSAID_hypersensitivity_reactions wikiPageWikiLink ALOX5.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Acute_generalized_exanthematous_pustulosis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Allergy.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Anaphylaxis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Angioedema.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Arachidonate_5-lipoxygenase.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Aspirin-induced_asthma.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Bronchoconstriction.
- NSAID_hypersensitivity_reactions wikiPageWikiLink CCL11.
- NSAID_hypersensitivity_reactions wikiPageWikiLink CCL24.
- NSAID_hypersensitivity_reactions wikiPageWikiLink CCL5.
- NSAID_hypersensitivity_reactions wikiPageWikiLink CCL7.
- NSAID_hypersensitivity_reactions wikiPageWikiLink CD4+_T_lymphocytes.
- NSAID_hypersensitivity_reactions wikiPageWikiLink COX-1.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Category:Hypersensitivity.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Chemokines%7D.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Contact_dermatitis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Cutaneous_condition.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Cytotoxic_T_cell.
- NSAID_hypersensitivity_reactions wikiPageWikiLink DRESS_syndrome.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Delayed_type_hypersensitivity.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Eotaxin-1.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Eotaxin-2.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Eoxin.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Eoxins.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Fixed_drug_eruption.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Fixed_drug_reaction.
- NSAID_hypersensitivity_reactions wikiPageWikiLink IgE.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Immunoglobulin_E.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Interleukin-5.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Interleukin_5.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Leukotriene.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Lipoxin.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Lipoxin_A4.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Maculopapular_rash.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Nasal_congestion.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Nonsteroidal_anti-inflammatory_drug.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Nonsteroidal_anti-inflammatory_drugs.
- NSAID_hypersensitivity_reactions wikiPageWikiLink PTGS1.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Photodermatitis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Photosensitivity_reaction.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Prostaglandin_E2.
- NSAID_hypersensitivity_reactions wikiPageWikiLink RANTES.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Rhinitis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Rhinorrhea.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Sinusitis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Stevens–Johnson_syndrome.
- NSAID_hypersensitivity_reactions wikiPageWikiLink T_helper_cell.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Toxic_epidermal_necrolysis.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Type_IV_hypersensitivity.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Urticaria.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Urticarial.
- NSAID_hypersensitivity_reactions wikiPageWikiLink Wheals.
- NSAID_hypersensitivity_reactions wikiPageWikiLinkText "NSAID hypersensitivity reactions".
- NSAID_hypersensitivity_reactions hasPhotoCollection NSAID_hypersensitivity_reactions.
- NSAID_hypersensitivity_reactions wikiPageUsesTemplate Template:Multiple_issues.
- NSAID_hypersensitivity_reactions wikiPageUsesTemplate Template:Reflist.
- NSAID_hypersensitivity_reactions subject Category:Hypersensitivity.
- NSAID_hypersensitivity_reactions comment "NSAID or nonsteroidal anti-inflammatory drug hypersensitivity reactions encompasses a broad range of allergic or allergic-like symptoms that occur within minutes to hours after ingesting aspirin or other NSAID nonsteroidal anti-inflammatory drugs.".
- NSAID_hypersensitivity_reactions label "NSAID hypersensitivity reactions".
- NSAID_hypersensitivity_reactions wasDerivedFrom NSAID_hypersensitivity_reactions?oldid=673255179.
- NSAID_hypersensitivity_reactions isPrimaryTopicOf NSAID_hypersensitivity_reactions.