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- NS5B abstract "Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). It has the key function of replicating the HCV's viral RNA by using the viral positive RNA strand as its template and catalyzes the polymerization of ribonucleoside triphosphates (rNTP) during RNA replication. Several crystal structures of NS5B polymerase in several crystalline forms have been determined based on the same consensus sequence BK (HCV-BK, genotype 1). The structure can be represented by a right hand shape with fingers, palm, and thumb. The encircled active site, unique to NS5B, is contained within the palm structure of the protein. Recent studies on NS5B protein genotype 1b strain J4’s (HC-J4) structure indicate a presence of an active site where possible control of nucleotide binding occurs and initiation of de-novo RNA synthesis. De-novo adds necessary primers for initiation of RNA replication. Current research attempts to bind structures to this active site to alter its functionality in order to prevent further viral RNA replication.".
- NS5B thumbnail HCV_genome.png?width=300.
- NS5B wikiPageID "41748391".
- NS5B wikiPageLength "5188".
- NS5B wikiPageOutDegree "8".
- NS5B wikiPageRevisionID "678241331".
- NS5B wikiPageWikiLink Category:Hepatitis_C_virus.
- NS5B wikiPageWikiLink Category:Viral_nonstructural_proteins.
- NS5B wikiPageWikiLink Dasabuvir.
- NS5B wikiPageWikiLink Hepatitis_C_virus.
- NS5B wikiPageWikiLink Research.
- NS5B wikiPageWikiLink Sofosbuvir.
- NS5B wikiPageWikiLink Viral_protein.
- NS5B wikiPageWikiLink File:HCV_genome.png.
- NS5B wikiPageWikiLinkText "NS5B".
- NS5B hasPhotoCollection NS5B.
- NS5B wikiPageUsesTemplate Template:Reflist.
- NS5B wikiPageUsesTemplate Template:Viral_proteins.
- NS5B subject Category:Hepatitis_C_virus.
- NS5B subject Category:Viral_nonstructural_proteins.
- NS5B hypernym Protein.
- NS5B type Protein.
- NS5B comment "Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). It has the key function of replicating the HCV's viral RNA by using the viral positive RNA strand as its template and catalyzes the polymerization of ribonucleoside triphosphates (rNTP) during RNA replication. Several crystal structures of NS5B polymerase in several crystalline forms have been determined based on the same consensus sequence BK (HCV-BK, genotype 1).".
- NS5B label "NS5B".
- NS5B sameAs ARN_polymérase_du_VHC.
- NS5B sameAs m.0gklt7b.
- NS5B sameAs Q17120609.
- NS5B sameAs Q17120609.
- NS5B wasDerivedFrom NS5B?oldid=678241331.
- NS5B depiction HCV_genome.png.
- NS5B isPrimaryTopicOf NS5B.