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- NK-92 abstract "NK-92 is a continuously growing cell line that has features and characteristics of natural killer (NK) cells that every person has circulating in the blood. Blood NK cells and NK-92 recognize "invaders" such as viruses and fungus. Most importantly, NK-92, like blood NK cells, can attack cancer cells as long as the tumor has not grown out of control. NK-92 cells were isolated and characterized by the laboratory of Dr. H. Klingemann - at that time at the British Columbia Cancer Control Agency in Vancouver, Canada. The cells came from a patient who had a NK cell lymphoma, a rare lymphoma type. Although several other NK cell lines have been cloned, only NK-92 can be expanded to larger numbers and consistently kill tumor cells vigorously. When NK-92 cells bind to a cancer or infected cell, they secrete perforin which punches holes in target cells followed by release of granzymes which induce apoptosis in the target cells. NK-92 cells also attack cancer cells through the Fas-Fas Ligand system and are capable of producing cytokines that by themselves can kill cancer cells (such as TNF-alpha) or stimulate and expand other immune cells such as interferon.Over the past 2 decades (the cell line was established in 1992) researchers worldwide have used NK-92 cells to test their anti-cancer activity in mouse models. and also use it as a model to learn more about the biology of NK cells. NK-92 cells are a very close match with blood NK cells: they express on their surface the characteristic CD56 antigen and are negative for CD3 which is typical for T-lymphocytes. In addition they express a number of adhesion molecules such as ICAM and LFA that facilitates binding to infected and cancer cells. Blood NK cells, NK-92 recognize "invaders" or foreign cells only if those cells do not express self MHC molecules. This means if cancer cells maintain their MHC phenotype they may go unnoticed by NK cells but not of NK-92 cells. The reason for this difference in target cell recognition relates to the fact that NK-92 cells do not express killer cell immunoglobulin‑like receptors (KIR) that are negative regulators of NK cell activity through interaction with self-MHC.".
- NK-92 wikiPageID "39124671".
- NK-92 wikiPageLength "8577".
- NK-92 wikiPageOutDegree "20".
- NK-92 wikiPageRevisionID "673710550".
- NK-92 wikiPageWikiLink Acute_leukemia.
- NK-92 wikiPageWikiLink Apoptosis.
- NK-92 wikiPageWikiLink Category:Cancer_treatments.
- NK-92 wikiPageWikiLink Category:Cell_lines.
- NK-92 wikiPageWikiLink Cell_culture.
- NK-92 wikiPageWikiLink Cell_line.
- NK-92 wikiPageWikiLink Chicago.
- NK-92 wikiPageWikiLink Chronic_leukemia.
- NK-92 wikiPageWikiLink Goethe_University_Frankfurt.
- NK-92 wikiPageWikiLink Granzyme.
- NK-92 wikiPageWikiLink Granzymes.
- NK-92 wikiPageWikiLink Lymph_node.
- NK-92 wikiPageWikiLink Lymphoma.
- NK-92 wikiPageWikiLink MRNA.
- NK-92 wikiPageWikiLink Messenger_RNA.
- NK-92 wikiPageWikiLink Monoclonal_antibodies.
- NK-92 wikiPageWikiLink Monoclonal_antibody.
- NK-92 wikiPageWikiLink NantKwest.
- NK-92 wikiPageWikiLink Natural_killer_cell.
- NK-92 wikiPageWikiLink Natural_killer_cells.
- NK-92 wikiPageWikiLink Perforin.
- NK-92 wikiPageWikiLink Princess_Margaret_Cancer_Centre.
- NK-92 wikiPageWikiLink Rush_University_Medical_Center.
- NK-92 wikiPageWikiLink T-lymphocyte.
- NK-92 wikiPageWikiLink T_cell.
- NK-92 wikiPageWikiLink Toronto.
- NK-92 wikiPageWikiLinkText "NK-92".
- NK-92 hasPhotoCollection NK-92.
- NK-92 wikiPageUsesTemplate Template:Multiple_issues.
- NK-92 wikiPageUsesTemplate Template:Nbhyph.
- NK-92 wikiPageUsesTemplate Template:Reflist.
- NK-92 subject Category:Cancer_treatments.
- NK-92 subject Category:Cell_lines.
- NK-92 type Article.
- NK-92 type Article.
- NK-92 type Page.
- NK-92 comment "NK-92 is a continuously growing cell line that has features and characteristics of natural killer (NK) cells that every person has circulating in the blood. Blood NK cells and NK-92 recognize "invaders" such as viruses and fungus. Most importantly, NK-92, like blood NK cells, can attack cancer cells as long as the tumor has not grown out of control. NK-92 cells were isolated and characterized by the laboratory of Dr. H.".
- NK-92 label "NK-92".
- NK-92 sameAs m.0t53nxc.
- NK-92 sameAs Q17149636.
- NK-92 sameAs Q17149636.
- NK-92 wasDerivedFrom NK-92?oldid=673710550.
- NK-92 isPrimaryTopicOf NK-92.