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- NH41 abstract "The NR4A1 gene is a transcription factor important in the development of cells that secrete the hormone insulin-like 3 (INSL3). In general, the NR4A gene family regulates cell growth and differentiation.In humans, INSL3 aids in the regulation of testicular descent during fetal development. In an adult INSL3 helps in keeping germ cells alive, in both males and females.In the male reproductive system the NR4A1 gene is a promoter of insulin-like 3 in Leydig cells. Leydig cells are located in the testis and known for the function as a support cell in spermatogenesis. Along with other things they secrete testosterone.In females, INSL3 is also involved in the reproductive system. It is secreted by thecal and luteal cells in the ovary and thus is important in the maturation of developing oocytes. In the rabbit model, disorders observed involving NR4A1 expression include testicular dysgenesis, and cryptorchidism.Immunoprecipitation assays show that INSL3 does bind to NR4A1; however, much is still not known about INSL3 regulation and the direct involvement of the NR4A1 gene.".
- NH41 wikiPageID "41087345".
- NH41 wikiPageLength "1955".
- NH41 wikiPageOutDegree "24".
- NH41 wikiPageRevisionID "626474320".
- NH41 wikiPageWikiLink Category:Genes.
- NH41 wikiPageWikiLink Category:Human_proteins.
- NH41 wikiPageWikiLink Category:Transcription_factors.
- NH41 wikiPageWikiLink Cell_(biology).
- NH41 wikiPageWikiLink Cell_growth.
- NH41 wikiPageWikiLink Cellular_differentiation.
- NH41 wikiPageWikiLink Corpus_luteum.
- NH41 wikiPageWikiLink Cryptorchidism.
- NH41 wikiPageWikiLink Fetal_development.
- NH41 wikiPageWikiLink Germ_cell.
- NH41 wikiPageWikiLink Gonadal_dysgenesis.
- NH41 wikiPageWikiLink Hormone.
- NH41 wikiPageWikiLink INSL3.
- NH41 wikiPageWikiLink Immunoprecipitation.
- NH41 wikiPageWikiLink Leydig_cell.
- NH41 wikiPageWikiLink Luteal_cells.
- NH41 wikiPageWikiLink Oocyte.
- NH41 wikiPageWikiLink Ovary.
- NH41 wikiPageWikiLink Prenatal_development.
- NH41 wikiPageWikiLink Reproductive_system.
- NH41 wikiPageWikiLink Spermatogenesis.
- NH41 wikiPageWikiLink Testicle.
- NH41 wikiPageWikiLink Testicular_dysgenesis.
- NH41 wikiPageWikiLink Testosterone.
- NH41 wikiPageWikiLink Theca_of_follicle.
- NH41 wikiPageWikiLink Thecal_cell.
- NH41 wikiPageWikiLink Transcription_factor.
- NH41 wikiPageWikiLinkText "NH41".
- NH41 hasPhotoCollection NH41.
- NH41 wikiPageUsesTemplate Template:Gene-stub.
- NH41 wikiPageUsesTemplate Template:Orphan.
- NH41 wikiPageUsesTemplate Template:Reflist.
- NH41 subject Category:Genes.
- NH41 subject Category:Human_proteins.
- NH41 subject Category:Transcription_factors.
- NH41 hypernym Factor.
- NH41 type Protein.
- NH41 comment "The NR4A1 gene is a transcription factor important in the development of cells that secrete the hormone insulin-like 3 (INSL3). In general, the NR4A gene family regulates cell growth and differentiation.In humans, INSL3 aids in the regulation of testicular descent during fetal development. In an adult INSL3 helps in keeping germ cells alive, in both males and females.In the male reproductive system the NR4A1 gene is a promoter of insulin-like 3 in Leydig cells.".
- NH41 label "NH41".
- NH41 sameAs m.011x62x1.
- NH41 sameAs Q16252582.
- NH41 sameAs Q16252582.
- NH41 wasDerivedFrom NH41?oldid=626474320.
- NH41 isPrimaryTopicOf NH41.