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- NFAT abstract "Nuclear factor of activated T-cells (NFAT) is a general name applied to a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems.The NFAT transcription factor family consists of five members NFATc1, NFATc2, NFATc3, NFATc4, and NFAT5. NFATc1 through NFATc4 are regulated by calcium signaling. Calcium signaling is critical to NFAT activation because calmodulin (CaM), a well-known calcium sensor protein, activates the serine/threonine phosphatase calcineurin (CN). Activated CN rapidly dephosphorylates the serine-rich region (SRR) and SP-repeats in the amino termini of NFAT proteins, resulting in a conformational change that exposes a nuclear localization signal, resulting in NFAT nuclear import.Nuclear import of NFAT proteins is opposed by maintenance kinases in the cytoplasm and export kinases in the nucleus. Export kinases, such as PKA and GSK-3β, must be inactivated for NFAT nuclear retention.NFAT proteins have weak DNA-binding capacity. Therefore, to effectively bind DNA, NFAT proteins must cooperate with other nuclear resident transcription factors generically referred to as NFATn. This important feature of NFAT transcription factors enables integration and coincidence detection of calcium signals with other signaling pathways such as ras-MAPK or PKC. In addition, this signaling integration is involved in tissue-specific gene expression during development. A screen of ncRNA sequences identified in EST sequencing projects discovered a 'ncRNA repressor of the nuclear factor of activated T cells' called NRON.".
- NFAT wikiPageID "7244534".
- NFAT wikiPageLength "5622".
- NFAT wikiPageOutDegree "19".
- NFAT wikiPageRevisionID "678978842".
- NFAT wikiPageWikiLink Breast_cancer.
- NFAT wikiPageWikiLink Calcineurin.
- NFAT wikiPageWikiLink Calmodulin.
- NFAT wikiPageWikiLink Category:Immune_system.
- NFAT wikiPageWikiLink Category:Transcription_factors.
- NFAT wikiPageWikiLink Cell_migration.
- NFAT wikiPageWikiLink Cell_motility.
- NFAT wikiPageWikiLink Expressed_sequence_tag.
- NFAT wikiPageWikiLink GSK-3β.
- NFAT wikiPageWikiLink GSK3B.
- NFAT wikiPageWikiLink Immune_response.
- NFAT wikiPageWikiLink Immune_system.
- NFAT wikiPageWikiLink Metastasis.
- NFAT wikiPageWikiLink NFAT5.
- NFAT wikiPageWikiLink NFATC1.
- NFAT wikiPageWikiLink NFATC2.
- NFAT wikiPageWikiLink NFATC3.
- NFAT wikiPageWikiLink NFATC4.
- NFAT wikiPageWikiLink NRON.
- NFAT wikiPageWikiLink NcRNA.
- NFAT wikiPageWikiLink Non-coding_RNA.
- NFAT wikiPageWikiLink Protein_kinase_A.
- NFAT wikiPageWikiLink Transcription_factor.
- NFAT wikiPageWikiLinkText "NFAT".
- NFAT hasPhotoCollection NFAT.
- NFAT wikiPageUsesTemplate Template:Reflist.
- NFAT wikiPageUsesTemplate Template:Transcription_factors.
- NFAT subject Category:Immune_system.
- NFAT subject Category:Transcription_factors.
- NFAT hypernym Name.
- NFAT type Article.
- NFAT type Article.
- NFAT type Factor.
- NFAT comment "Nuclear factor of activated T-cells (NFAT) is a general name applied to a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems.The NFAT transcription factor family consists of five members NFATc1, NFATc2, NFATc3, NFATc4, and NFAT5. NFATc1 through NFATc4 are regulated by calcium signaling.".
- NFAT label "NFAT".
- NFAT sameAs NFAT.
- NFAT sameAs NF-AT.
- NFAT sameAs NFAT.
- NFAT sameAs m.025x2s_.
- NFAT sameAs Q421513.
- NFAT sameAs Q421513.
- NFAT wasDerivedFrom NFAT?oldid=678978842.
- NFAT isPrimaryTopicOf NFAT.