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- NEDD8 abstract "NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (In Saccharomyces cerevisiae this protein is known as Rub1.) This ubiquitin-like protein (ULP), which becomes covalently conjugated to a limited number of cellular proteins in a manner analogous to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.As with ubiquitin and SUMO, NEDD8 is conjugated to cellular proteins after its C-terminal tail is processed. The NEDD8 activating E1 enzyme is a heterodimer composed of APPBP1 and UBA3 subunits. The APPBP1/UBA3 enzyme has homology to the N- and C-terminal halves of the ubiquitin E1 enzyme, respectively. The UBA3 subunit contains the catalytic center and activates NEDD8 in an ATP-dependent reaction by forming a high-energy thiolester intermediate. The activated NEDD8 is subsequently transferred to the UbcH12 E2 enzyme, and is then conjugated to specific substrates in the presence of the appropriate E3 ligases. There are several different proteases which can remove NEDD8 from protein conjugates. UCHL1, UCHL3 and USP21 proteases have dual specificity for NEDD8 and ubiquitin. Proteases specific for NEDD8 removal are the COP9 signalosome which removes NEDD8 from the CUL1 subunit of SCF ubiquitin ligases, and NEDP1 (or DEN1, SENP8).".
- NEDD8 entrezgene "4738".
- NEDD8 wikiPageID "14146889".
- NEDD8 wikiPageLength "11553".
- NEDD8 wikiPageOutDegree "11".
- NEDD8 wikiPageRevisionID "678978663".
- NEDD8 wikiPageWikiLink Aryl_hydrocarbon_receptor.
- NEDD8 wikiPageWikiLink Category:Human_proteins.
- NEDD8 wikiPageWikiLink Gene.
- NEDD8 wikiPageWikiLink NUB1.
- NEDD8 wikiPageWikiLink Protein.
- NEDD8 wikiPageWikiLink Protein-protein_interaction.
- NEDD8 wikiPageWikiLink Protein–protein_interaction.
- NEDD8 wikiPageWikiLink Saccharomyces_cerevisiae.
- NEDD8 wikiPageWikiLink UBE1C.
- NEDD8 wikiPageWikiLink UBE2M.
- NEDD8 wikiPageWikiLink UCHL3.
- NEDD8 wikiPageWikiLink Ubiquitin.
- NEDD8 wikiPageWikiLink Ubiquitination.
- NEDD8 wikiPageWikiLinkText "NEDD8".
- NEDD8 wikiPageWikiLinkText "Nedd8".
- NEDD8 hasPhotoCollection NEDD8.
- NEDD8 requireManualInspection "no".
- NEDD8 updateCitations "yes".
- NEDD8 updatePage "yes".
- NEDD8 updateProteinBox "yes".
- NEDD8 updateSummary "yes".
- NEDD8 wikiPageUsesTemplate Template:Gene-14-stub.
- NEDD8 wikiPageUsesTemplate Template:PBB.
- NEDD8 wikiPageUsesTemplate Template:PBB_Controls.
- NEDD8 wikiPageUsesTemplate Template:PBB_Further_reading.
- NEDD8 wikiPageUsesTemplate Template:PBB_Summary.
- NEDD8 wikiPageUsesTemplate Template:PDB_Gallery.
- NEDD8 wikiPageUsesTemplate Template:Refbegin.
- NEDD8 wikiPageUsesTemplate Template:Refend.
- NEDD8 wikiPageUsesTemplate Template:Reflist.
- NEDD8 subject Category:Human_proteins.
- NEDD8 hypernym Protein.
- NEDD8 type Biomolecule.
- NEDD8 type Protein.
- NEDD8 type Thing.
- NEDD8 type Q206229.
- NEDD8 type Q8054.
- NEDD8 comment "NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (In Saccharomyces cerevisiae this protein is known as Rub1.) This ubiquitin-like protein (ULP), which becomes covalently conjugated to a limited number of cellular proteins in a manner analogous to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases.".
- NEDD8 label "NEDD8".
- NEDD8 sameAs m.03cw10t.
- NEDD8 sameAs Q6953444.
- NEDD8 sameAs Q6953444.
- NEDD8 wasDerivedFrom NEDD8?oldid=678978663.
- NEDD8 isPrimaryTopicOf NEDD8.