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- NAGPA abstract "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene.Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.".
- NAGPA entrezgene "51172".
- NAGPA wikiPageID "15063098".
- NAGPA wikiPageLength "5473".
- NAGPA wikiPageOutDegree "9".
- NAGPA wikiPageRevisionID "678978082".
- NAGPA wikiPageWikiLink Category:Human_proteins.
- NAGPA wikiPageWikiLink Enzyme.
- NAGPA wikiPageWikiLink Gene.
- NAGPA wikiPageWikiLink Golgi_apparatus.
- NAGPA wikiPageWikiLink Homotetramer.
- NAGPA wikiPageWikiLink Hydrolase.
- NAGPA wikiPageWikiLink Hydrolases.
- NAGPA wikiPageWikiLink Mannose_6-phosphate_receptor.
- NAGPA wikiPageWikiLink N-terminal.
- NAGPA wikiPageWikiLink N-terminus.
- NAGPA wikiPageWikiLink Signal_peptide.
- NAGPA wikiPageWikiLink Trans-Golgi_network.
- NAGPA wikiPageWikiLinkText "NAGPA".
- NAGPA hasPhotoCollection NAGPA.
- NAGPA requireManualInspection "no".
- NAGPA summaryText "Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.".
- NAGPA updateCitations "yes".
- NAGPA updatePage "yes".
- NAGPA updateProteinBox "yes".
- NAGPA updateSummary "yes".
- NAGPA wikiPageUsesTemplate Template:Gene-16-stub.
- NAGPA wikiPageUsesTemplate Template:PBB.
- NAGPA wikiPageUsesTemplate Template:PBB_Controls.
- NAGPA wikiPageUsesTemplate Template:PBB_Further_reading.
- NAGPA wikiPageUsesTemplate Template:PBB_Summary.
- NAGPA wikiPageUsesTemplate Template:Refbegin.
- NAGPA wikiPageUsesTemplate Template:Refend.
- NAGPA wikiPageUsesTemplate Template:Reflist.
- NAGPA subject Category:Human_proteins.
- NAGPA hypernym Enzyme.
- NAGPA type Biomolecule.
- NAGPA type Protein.
- NAGPA type Thing.
- NAGPA type Q206229.
- NAGPA type Q8054.
- NAGPA comment "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene.Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases.".
- NAGPA label "NAGPA".
- NAGPA sameAs m.03hg754.
- NAGPA sameAs Q15996865.
- NAGPA sameAs Q15996865.
- NAGPA wasDerivedFrom NAGPA?oldid=678978082.
- NAGPA isPrimaryTopicOf NAGPA.