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- Myeloma_protein abstract "A myeloma protein is an abnormal immunoglobulin fragment or immunoglobulin light chain that is produced in excess by an abnormal clonal proliferation of plasma cells, typically in multiple myeloma. Other terms for such a protein are M protein, M component, spike protein, or paraprotein. This proliferation of the myeloma protein has several deleterious effects on the body, including impaired immune function, abnormally high viscosity ("thickness") of the blood, and kidney damage.Myeloma is a malignancy of the plasma cell. Plasma cells produce immunoglobulins, which are commonly called antibodies. There are literally thousands of different antibodies, each consisting of pairs of heavy and light chains. Antibodies are typically grouped into five types: IgA, IgD, IgE, IgG, and IgM. When someone contracts myeloma, a malignant clone, a rogue plasma cell, reproduces in an uncontrolled fashion, resulting in overproduction of the specific antibody that it was designed to produce. Each type of antibody has a different number of light chain and heavy chain pairs. As a result, there is a characteristic normal distribution of these antibodies in the blood by molecular weight. When there is a malignant clone, there is usually overproduction of a single antibody, resulting in a "spike" on the normal distribution, which is called an M spike (or monoclonal spike). People will sometimes develop a condition called MGUS (Monoclonal gammopathy of undetermined significance), where there is overproduction of one antibody but the condition is benign (does not threaten the patient's health). An explanation of the difference between multiple myeloma and MGUS can be found in the International Myeloma Foundation's Patient Handbook and Concise ReviewDetection of paraproteins in the urine or blood is most often associated with benign monoclonal gammopathy of undetermined significance (MGUS), where they remain "silent", and multiple myeloma. An excess in the blood is known as paraproteinemia. Paraproteins form a narrow band, or 'spike' in protein electrophoresis as they are all exactly the same protein. Unlike normal immunoglobulin antibodies, paraproteins cannot fight infection.Serum free light-chain measurement can detect free light chains in the blood. Monoclonal free light chains in the serum or urine are called Bence Jones proteins.".
- Myeloma_protein thumbnail Monoclonal_gammopathy_Multiple_Myeloma.png?width=300.
- Myeloma_protein wikiPageExternalLink paraprotyp.html.
- Myeloma_protein wikiPageExternalLink Biology_of_immunoglobulin_light_chains.
- Myeloma_protein wikiPageID "14123742".
- Myeloma_protein wikiPageLength "5651".
- Myeloma_protein wikiPageOutDegree "29".
- Myeloma_protein wikiPageRevisionID "670821746".
- Myeloma_protein wikiPageWikiLink Antibody.
- Myeloma_protein wikiPageWikiLink Bence_Jones_protein.
- Myeloma_protein wikiPageWikiLink Berlin.
- Myeloma_protein wikiPageWikiLink Blood.
- Myeloma_protein wikiPageWikiLink Blood_serum.
- Myeloma_protein wikiPageWikiLink Category:Hematology.
- Myeloma_protein wikiPageWikiLink Category:Immune_system.
- Myeloma_protein wikiPageWikiLink Category:Oncology.
- Myeloma_protein wikiPageWikiLink Category:Proteins.
- Myeloma_protein wikiPageWikiLink Charité.
- Myeloma_protein wikiPageWikiLink Clonal.
- Myeloma_protein wikiPageWikiLink Gel_electrophoresis_of_proteins.
- Myeloma_protein wikiPageWikiLink Immunoglobulin.
- Myeloma_protein wikiPageWikiLink Immunoglobulin_light_chain.
- Myeloma_protein wikiPageWikiLink International_Myeloma_Foundation.
- Myeloma_protein wikiPageWikiLink International_Myeloma_Working_Group.
- Myeloma_protein wikiPageWikiLink Kidney.
- Myeloma_protein wikiPageWikiLink Monoclonal_antibodies.
- Myeloma_protein wikiPageWikiLink Monoclonal_antibody.
- Myeloma_protein wikiPageWikiLink Monoclonal_gammopathy_of_undetermined_significance.
- Myeloma_protein wikiPageWikiLink Multiple_myeloma.
- Myeloma_protein wikiPageWikiLink Paraproteinemia.
- Myeloma_protein wikiPageWikiLink Plasma_cell.
- Myeloma_protein wikiPageWikiLink Protein_electrophoresis.
- Myeloma_protein wikiPageWikiLink Serum_(blood).
- Myeloma_protein wikiPageWikiLink Serum_free_light-chain_measurement.
- Myeloma_protein wikiPageWikiLink Tuftsin.
- Myeloma_protein wikiPageWikiLink Urine.
- Myeloma_protein wikiPageWikiLink Viscosity.
- Myeloma_protein wikiPageWikiLink File:Monoclonal_gammopathy_Multiple_Myeloma.png.
- Myeloma_protein wikiPageWikiLinkText "Myeloma protein".
- Myeloma_protein wikiPageWikiLinkText "myeloma protein".
- Myeloma_protein wikiPageWikiLinkText "paraprotein".
- Myeloma_protein hasPhotoCollection Myeloma_protein.
- Myeloma_protein wikiPageUsesTemplate Template:MeshName.
- Myeloma_protein wikiPageUsesTemplate Template:Reflist.
- Myeloma_protein subject Category:Hematology.
- Myeloma_protein subject Category:Immune_system.
- Myeloma_protein subject Category:Oncology.
- Myeloma_protein subject Category:Proteins.
- Myeloma_protein hypernym Fragment.
- Myeloma_protein type Drug.
- Myeloma_protein type Specialty.
- Myeloma_protein comment "A myeloma protein is an abnormal immunoglobulin fragment or immunoglobulin light chain that is produced in excess by an abnormal clonal proliferation of plasma cells, typically in multiple myeloma. Other terms for such a protein are M protein, M component, spike protein, or paraprotein.".
- Myeloma_protein label "Myeloma protein".
- Myeloma_protein sameAs m.03cvb5d.
- Myeloma_protein sameAs Q6947334.
- Myeloma_protein sameAs Q6947334.
- Myeloma_protein wasDerivedFrom Myeloma_protein?oldid=670821746.
- Myeloma_protein depiction Monoclonal_gammopathy_Multiple_Myeloma.png.
- Myeloma_protein isPrimaryTopicOf Myeloma_protein.