Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/MutS-1> ?p ?o }
- MutS-1 abstract "Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element (Klenow fragment) of the DNA polymerase complex. The post-replicative Mismatch Repair System (MMRS) of Escherichia coli involves MutS (Mutator S), MutL and MutH proteins, and acts to correct point mutations or small insertion/deletion loops produced during DNA replication. MutS and MutL are involved in preventing recombination between partially homologous DNA sequences. The assembly of MMRS is initiated by MutS, which recognizes and binds to mispaired nucleotides and allows further action of MutL and MutH to eliminate a portion of newly synthesized DNA strand containing the mispaired base. MutS can also collaborate with methyltransferases in the repair of O(6)-methylguanine damage, which would otherwise pair with thymine during replication to create an O(6)mG:T mismatch. MutS exists as a dimer, where the two monomers have different conformations and form a heterodimer at the structural level. Only one monomer recognises the mismatch specifically and has ADP bound. Non-specific major groove DNA-binding domains from both monomers embrace the DNA in a clamp-like structure. Mismatch binding induces ATP uptake and a conformational change in the MutS protein, resulting in a clamp that translocates on DNA.MutS is a modular protein with a complex structure, and is composed of:N-terminal mismatch-recognition domain, which is similar in structure to tRNA endonuclease.Connector domain, which is similar in structure to Holliday junction resolvase ruvC.Core domain, which is composed of two separate subdomains that join together to form a helical bundle; from within the core domain, two helices act as levers that extend towards (but do not touch) the DNA.Clamp domain, which is inserted between the two subdomains of the core domain at the top of the lever helices; the clamp domain has a beta-sheet structure.ATPase domain (connected to the core domain), which has a classical Walker A motif.HTH (helix-turn-helix) domain, which is involved in dimer contacts.Homologues of MutS have been found in many species including eukaryotes (MSH 1, 2, 3, 4, 5, and 6 proteins), archaea and bacteria, and together these proteins have been grouped into the MutS family. Although many of these proteins have similar activities to the E. coli MutS, there is significant diversity of function among the MutS family members. This diversity is even seen within species, where many species encode multiple MutS homologues with distinct functions. Inter-species homologues may have arisen through frequent ancient horizontal gene transfer of MutS (and MutL) from bacteria to archaea and eukaryotes via endosymbiotic ancestors of mitochondria and chloroplasts.This entry represents the N-terminal domain of proteins in the MutS family of DNA mismatch repair proteins, as well as closely related proteins. The N-terminal domain of MutS is responsible for mismatch recognition and forms a 6-stranded mixed beta-sheet surrounded by three alpha-helices, which is similar to the structure of tRNA endonuclease. Yeast MSH3, bacterial proteins involved in DNA mismatch repair, and the predicted protein product of the Rep-3 gene of mouse share extensive sequence similarity. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein.".
- MutS-1 symbol "MutS_I".
- MutS-1 thumbnail PDB_1oh6_EBI.jpg?width=300.
- MutS-1 wikiPageID "32116368".
- MutS-1 wikiPageLength "7738".
- MutS-1 wikiPageOutDegree "63".
- MutS-1 wikiPageRevisionID "672114385".
- MutS-1 wikiPageWikiLink Adverse_effect.
- MutS-1 wikiPageWikiLink Adverse_effect_(medicine).
- MutS-1 wikiPageWikiLink Alpha_helix.
- MutS-1 wikiPageWikiLink Archaea.
- MutS-1 wikiPageWikiLink Bacteria.
- MutS-1 wikiPageWikiLink Base_(chemistry).
- MutS-1 wikiPageWikiLink Base_pair.
- MutS-1 wikiPageWikiLink Base_pairs.
- MutS-1 wikiPageWikiLink Beta-sheet.
- MutS-1 wikiPageWikiLink Beta_sheet.
- MutS-1 wikiPageWikiLink Binding_(molecular).
- MutS-1 wikiPageWikiLink Biomolecular_structure.
- MutS-1 wikiPageWikiLink Carcinoma.
- MutS-1 wikiPageWikiLink Category:Protein_domains.
- MutS-1 wikiPageWikiLink Chemical_conformation.
- MutS-1 wikiPageWikiLink Chemical_structure.
- MutS-1 wikiPageWikiLink Chloroplast.
- MutS-1 wikiPageWikiLink Cis-Regulatory_element.
- MutS-1 wikiPageWikiLink Cis-regulatory_element.
- MutS-1 wikiPageWikiLink Complex_(chemistry).
- MutS-1 wikiPageWikiLink Conformational_change.
- MutS-1 wikiPageWikiLink Coordination_complex.
- MutS-1 wikiPageWikiLink DNA_mismatch_repair.
- MutS-1 wikiPageWikiLink DNA_replication.
- MutS-1 wikiPageWikiLink Domain_(biology).
- MutS-1 wikiPageWikiLink Endonuclease.
- MutS-1 wikiPageWikiLink Eukaryote.
- MutS-1 wikiPageWikiLink Eukaryotes.
- MutS-1 wikiPageWikiLink Genetic_recombination.
- MutS-1 wikiPageWikiLink Genome.
- MutS-1 wikiPageWikiLink Helical.
- MutS-1 wikiPageWikiLink Helix.
- MutS-1 wikiPageWikiLink Heterodimer.
- MutS-1 wikiPageWikiLink Homo_sapiens.
- MutS-1 wikiPageWikiLink Homology_(biology).
- MutS-1 wikiPageWikiLink Horizontal_gene_transfer.
- MutS-1 wikiPageWikiLink House_mouse.
- MutS-1 wikiPageWikiLink Klenow_fragment.
- MutS-1 wikiPageWikiLink Loop_(biochemistry).
- MutS-1 wikiPageWikiLink Methyltransferase.
- MutS-1 wikiPageWikiLink Mitochondria.
- MutS-1 wikiPageWikiLink Mitochondrion.
- MutS-1 wikiPageWikiLink Molecular_binding.
- MutS-1 wikiPageWikiLink Monomer.
- MutS-1 wikiPageWikiLink Multiprotein_complex.
- MutS-1 wikiPageWikiLink Mus_musculus.
- MutS-1 wikiPageWikiLink Nucleic_acid_structure.
- MutS-1 wikiPageWikiLink Nucleotide.
- MutS-1 wikiPageWikiLink Point_mutation.
- MutS-1 wikiPageWikiLink Polymerase.
- MutS-1 wikiPageWikiLink Product_(chemistry).
- MutS-1 wikiPageWikiLink Proofreading_(biology).
- MutS-1 wikiPageWikiLink Protein.
- MutS-1 wikiPageWikiLink Protein_complex.
- MutS-1 wikiPageWikiLink Protein_dimer.
- MutS-1 wikiPageWikiLink Protein_domain.
- MutS-1 wikiPageWikiLink Protein_motif.
- MutS-1 wikiPageWikiLink Protein_structure.
- MutS-1 wikiPageWikiLink Protein_targeting.
- MutS-1 wikiPageWikiLink Proteins.
- MutS-1 wikiPageWikiLink RNA_structure.
- MutS-1 wikiPageWikiLink Regulation_of_gene_expression.
- MutS-1 wikiPageWikiLink Saccharomyces_cerevisiae.
- MutS-1 wikiPageWikiLink Secondary_structure.
- MutS-1 wikiPageWikiLink Sequence.
- MutS-1 wikiPageWikiLink Sequence_(biology).
- MutS-1 wikiPageWikiLink Species.
- MutS-1 wikiPageWikiLink Structural_motif.
- MutS-1 wikiPageWikiLink Structure.
- MutS-1 wikiPageWikiLink Tertiary_structure.
- MutS-1 wikiPageWikiLink Turn_(biochemistry).
- MutS-1 wikiPageWikiLink Zinc-dependent_phospholipase_C.
- MutS-1 wikiPageWikiLink Zinc_dependent_phospholipase_C.
- MutS-1 wikiPageWikiLinkText "MutS".
- MutS-1 wikiPageWikiLinkText "MutS-1".
- MutS-1 wikiPageWikiLinkText "mutS family".
- MutS-1 caption "The crystal structure of E. coli MutS binding to DNA with an a:a mismatch".
- MutS-1 hasPhotoCollection MutS-1.
- MutS-1 interpro "IPR007695".
- MutS-1 name "MutS_I".
- MutS-1 pfam "PF01624".
- MutS-1 prosite "PDOC00388".
- MutS-1 scop "1".
- MutS-1 smart "MUTSd".
- MutS-1 symbol "MutS_I".
- MutS-1 wikiPageUsesTemplate Template:Infobox_protein_family.
- MutS-1 wikiPageUsesTemplate Template:InterPro_content.
- MutS-1 wikiPageUsesTemplate Template:Reflist.
- MutS-1 subject Category:Protein_domains.
- MutS-1 type Biomolecule.
- MutS-1 type Protein.
- MutS-1 type Chemical.
- MutS-1 type Domain.