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- Muramyl_ligase abstract "The bacterial cell wall provides strength and rigidity to counteract internal osmotic pressure, and protection against the environment. The peptidoglycan layer gives the cell wall its strength, and helps maintain the overall shape of the cell. The basic peptidoglycan structure of both Gram-positive and Gram-negative bacteria comprises a sheet of glycan chains connected by short cross-linking polypeptides. Biosynthesis of peptidoglycan is a multi-step (11-12 steps) process comprising three main stages:(1) formation of UDP-N-acetylmuramic acid (UDPMurNAc) from N-acetylglucosamine (GlcNAc). (2) addition of a short polypeptide chain to the UDPMurNAc. (3) addition of a second GlcNAc to the disaccharide-pentapeptide building block and transport of this unit through the cytoplasmic membrane and incorporation into the growing peptidoglycan layer. Stage two involves four key Mur ubiquitin ligase enzymes: MurC (EC), MurD (EC), MurE (EC) and MurF (EC). These four Mur ligases are responsible for the successive additions of L-alanine, D-glutamate, meso-diaminopimelate or L-lysine, and D-alanyl-D-alanine to UDP-N-acetylmuramic acid. All four Mur ligases are topologically similar to one another, even though they display low sequence identity. They are each composed of three domains: an N-terminal Rossmann-fold domain responsible for binding the UDPMurNAc substrate; a central domain (similar to ATP-binding domains of several ATPases and GTPases); and a C-terminal domain (similar to dihydrofolate reductase fold) that appears to be associated with binding the incoming amino acid. The conserved sequence motifs found in the four Mur enzymes also map to other members of the Mur ligase family, including folylpolyglutamate synthetase, cyanophycin synthetase and the capB enzyme from Bacillales.This family includes UDP-N-acetylmuramate-L-alanine ligase (MurC), UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (MurE), and UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF). This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase that catalyses the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin).".
- Muramyl_ligase symbol "Mur_ligase".
- Muramyl_ligase wikiPageExternalLink 6.3.2.10.
- Muramyl_ligase wikiPageExternalLink 6.3.2.13.
- Muramyl_ligase wikiPageExternalLink 6.3.2.8.
- Muramyl_ligase wikiPageExternalLink 6.3.2.9.
- Muramyl_ligase wikiPageID "35666184".
- Muramyl_ligase wikiPageLength "5557".
- Muramyl_ligase wikiPageOutDegree "36".
- Muramyl_ligase wikiPageRevisionID "592600878".
- Muramyl_ligase wikiPageWikiLink Amino_acid.
- Muramyl_ligase wikiPageWikiLink Bacteria.
- Muramyl_ligase wikiPageWikiLink Base_(chemistry).
- Muramyl_ligase wikiPageWikiLink Binding_(molecular).
- Muramyl_ligase wikiPageWikiLink Biosynthesis.
- Muramyl_ligase wikiPageWikiLink Catalysis.
- Muramyl_ligase wikiPageWikiLink Category:EC_6.3.2.
- Muramyl_ligase wikiPageWikiLink Category:Enzymes_of_known_structure.
- Muramyl_ligase wikiPageWikiLink Category:Protein_domains.
- Muramyl_ligase wikiPageWikiLink Cell_(biology).
- Muramyl_ligase wikiPageWikiLink Cell_membrane.
- Muramyl_ligase wikiPageWikiLink Cell_wall.
- Muramyl_ligase wikiPageWikiLink Cyanophycin.
- Muramyl_ligase wikiPageWikiLink Cytoplasmic_membrane.
- Muramyl_ligase wikiPageWikiLink Diaminopimelate.
- Muramyl_ligase wikiPageWikiLink Diaminopimelic_acid.
- Muramyl_ligase wikiPageWikiLink Dihydrofolate_reductase.
- Muramyl_ligase wikiPageWikiLink Domain_(biology).
- Muramyl_ligase wikiPageWikiLink Glutamic_acid.
- Muramyl_ligase wikiPageWikiLink Glycan.
- Muramyl_ligase wikiPageWikiLink Gram-negative.
- Muramyl_ligase wikiPageWikiLink Gram-negative_bacteria.
- Muramyl_ligase wikiPageWikiLink Gram-positive.
- Muramyl_ligase wikiPageWikiLink Gram-positive_bacteria.
- Muramyl_ligase wikiPageWikiLink Ligase.
- Muramyl_ligase wikiPageWikiLink Molecular_binding.
- Muramyl_ligase wikiPageWikiLink N-Acetylglucosamine.
- Muramyl_ligase wikiPageWikiLink N-Acetylmuramic_acid.
- Muramyl_ligase wikiPageWikiLink N-acetylglucosamine.
- Muramyl_ligase wikiPageWikiLink N-acetylmuramic_acid.
- Muramyl_ligase wikiPageWikiLink Peptide.
- Muramyl_ligase wikiPageWikiLink Peptidoglycan.
- Muramyl_ligase wikiPageWikiLink Polypeptide.
- Muramyl_ligase wikiPageWikiLink Polypeptides.
- Muramyl_ligase wikiPageWikiLink Protein_domain.
- Muramyl_ligase wikiPageWikiLink Sequence_(biology).
- Muramyl_ligase wikiPageWikiLink Sequence_motif.
- Muramyl_ligase wikiPageWikiLink Synthase.
- Muramyl_ligase wikiPageWikiLink Synthetase.
- Muramyl_ligase wikiPageWikiLink Transport.
- Muramyl_ligase wikiPageWikiLink Ubiquitin_ligase.
- Muramyl_ligase wikiPageWikiLink Virus.
- Muramyl_ligase wikiPageWikiLink Virus_structure.
- Muramyl_ligase wikiPageWikiLink Zinc-dependent_phospholipase_C.
- Muramyl_ligase wikiPageWikiLink Zinc_dependent_phospholipase_C.
- Muramyl_ligase wikiPageWikiLinkText "Muramyl ligase".
- Muramyl_ligase wikiPageWikiLinkText "mur ligase family".
- Muramyl_ligase hasPhotoCollection Muramyl_ligase.
- Muramyl_ligase interpro "IPR000713".
- Muramyl_ligase name "Mur_ligase".
- Muramyl_ligase opmFamily "415".
- Muramyl_ligase opmProtein "1".
- Muramyl_ligase pfam "PF01225".
- Muramyl_ligase pfamClan "CL0063".
- Muramyl_ligase prosite "PDOC00773".
- Muramyl_ligase scop "1".
- Muramyl_ligase symbol "Mur_ligase".
- Muramyl_ligase wikiPageUsesTemplate Template:Infobox_protein_family.
- Muramyl_ligase wikiPageUsesTemplate Template:InterPro_content.
- Muramyl_ligase wikiPageUsesTemplate Template:Reflist.
- Muramyl_ligase subject Category:EC_6.3.2.
- Muramyl_ligase subject Category:Enzymes_of_known_structure.
- Muramyl_ligase subject Category:Protein_domains.
- Muramyl_ligase type Biomolecule.
- Muramyl_ligase type Protein.
- Muramyl_ligase type Domain.
- Muramyl_ligase type Thing.
- Muramyl_ligase type Q206229.
- Muramyl_ligase type Q8054.
- Muramyl_ligase comment "The bacterial cell wall provides strength and rigidity to counteract internal osmotic pressure, and protection against the environment. The peptidoglycan layer gives the cell wall its strength, and helps maintain the overall shape of the cell. The basic peptidoglycan structure of both Gram-positive and Gram-negative bacteria comprises a sheet of glycan chains connected by short cross-linking polypeptides.".
- Muramyl_ligase label "Muramyl ligase".
- Muramyl_ligase sameAs m.0jk_bzl.
- Muramyl_ligase sameAs Q6937310.
- Muramyl_ligase sameAs Q6937310.
- Muramyl_ligase wasDerivedFrom Muramyl_ligase?oldid=592600878.
- Muramyl_ligase isPrimaryTopicOf Muramyl_ligase.