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- Mossy_fiber_(hippocampus) abstract "In the hippocampus, granule cells of the dentate gyrus form distinctive unmyelinated axons that project along the mossy fiber pathway to the Cornu Ammonis area 3 (CA3). The axons emerge from the basal portions of the granule cells and pass through the hilus (or polymorphic cell layer) of the dentate gyrus before entering the stratum lucidum of CA3. Granule cell synapses tend to be glutamatergic (e.g. excitatory), though immunohistological data has indicated that some synapses contain neuropeptidergic elements including opiate peptides such as dynorphin and enkephalin. Moreover, there is growing evidence for co-localization of GABAergic and glutamatergic neurotransmitters within mossy fiber terminals, though the functional consequence of this co-localization is unclear.The pathway was so named by Ramon y Cajal because the axons display varicosities all along their lengths, giving them a "mossy" appearance. They form three morphologically different synaptic terminals, which include the large "mossy terminals", "filopodial extensions" of the mossy terminals, and smaller "en passant" synaptic varicosities. Mossy fibers form multiple synapses with the elaborate dendritic spines of CA3 pyramidal cells in stratum lucidum. These complex spines are known as "thorny excrescences". It has also been shown that the axons of granule cells synapse with a wide variety of inhibitory GABAergic interneurons in the hilar region of the dentate gyrus before continuing on to innervate pyramidal cells in the CA3 region.A single mossy fiber projection may make as many as 37 contacts with a single pyramidal cell, but innervates only about a dozen different pyramidal cells. In contrast, a single CA3 pyramidal cell receives input from about 50 different granule cells. It has been shown in rodents that the size of the mossy fiber projections can show large interindividual variations, which are to a large part heritable. In addition, these variations show strong correlations with different types of behavior, mainly, but not exclusively, spatial learning.The synapses of the mossy fibers contain zinc, which can be stained specifically with a Timm staining.".
- Mossy_fiber_(hippocampus) thumbnail Diagram_of_a_Timm-stained_cross-section_of_the_hippocampus.JPEG?width=300.
- Mossy_fiber_(hippocampus) wikiPageID "8250177".
- Mossy_fiber_(hippocampus) wikiPageLength "5989".
- Mossy_fiber_(hippocampus) wikiPageOutDegree "27".
- Mossy_fiber_(hippocampus) wikiPageRevisionID "656648025".
- Mossy_fiber_(hippocampus) wikiPageWikiLink Axon.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Category:Limbic_system.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Category:Neuroanatomy.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Cornu_Ammonis_area_3.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Dentate_gyrus.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Dynorphin.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Enkephalin.
- Mossy_fiber_(hippocampus) wikiPageWikiLink GABAergic.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Glutamatergic.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Glutamic_acid.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Granule_cell.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Granule_cells.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Hippocampus.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Hippocampus_anatomy.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Immunohistochemistry.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Interneuron.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Mossy_fiber_(cerebellum).
- Mossy_fiber_(hippocampus) wikiPageWikiLink Myelin.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Myelinated.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Neuropeptidergic.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Opiate.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Peptide.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Pyramidal_cell.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Ramon_y_Cajal.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Santiago_Ramón_y_Cajal.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Spatial_learning.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Spatial_memory.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Stratum_lucidum_of_hippocampus.
- Mossy_fiber_(hippocampus) wikiPageWikiLink Synapse.
- Mossy_fiber_(hippocampus) wikiPageWikiLink File:Diagram_of_a_Timm-stained_cross-section_of_the_hippocampus.JPEG.
- Mossy_fiber_(hippocampus) wikiPageWikiLinkText "Mossy fiber (hippocampus)".
- Mossy_fiber_(hippocampus) wikiPageWikiLinkText "Mossy fibers".
- Mossy_fiber_(hippocampus) wikiPageWikiLinkText "mossy cells".
- Mossy_fiber_(hippocampus) wikiPageWikiLinkText "mossy fiber".
- Mossy_fiber_(hippocampus) wikiPageWikiLinkText "mossy fibers".
- Mossy_fiber_(hippocampus) hasPhotoCollection Mossy_fiber_(hippocampus).
- Mossy_fiber_(hippocampus) wikiPageUsesTemplate Template:For.
- Mossy_fiber_(hippocampus) wikiPageUsesTemplate Template:Portal.
- Mossy_fiber_(hippocampus) wikiPageUsesTemplate Template:Reflist.
- Mossy_fiber_(hippocampus) subject Category:Limbic_system.
- Mossy_fiber_(hippocampus) subject Category:Neuroanatomy.
- Mossy_fiber_(hippocampus) comment "In the hippocampus, granule cells of the dentate gyrus form distinctive unmyelinated axons that project along the mossy fiber pathway to the Cornu Ammonis area 3 (CA3). The axons emerge from the basal portions of the granule cells and pass through the hilus (or polymorphic cell layer) of the dentate gyrus before entering the stratum lucidum of CA3. Granule cell synapses tend to be glutamatergic (e.g.".
- Mossy_fiber_(hippocampus) label "Mossy fiber (hippocampus)".
- Mossy_fiber_(hippocampus) sameAs Włókna_kiciaste_(hipokamp).
- Mossy_fiber_(hippocampus) sameAs m.026xt8g.
- Mossy_fiber_(hippocampus) sameAs Q6916721.
- Mossy_fiber_(hippocampus) sameAs Q6916721.
- Mossy_fiber_(hippocampus) wasDerivedFrom Mossy_fiber_(hippocampus)?oldid=656648025.
- Mossy_fiber_(hippocampus) depiction Diagram_of_a_Timm-stained_cross-section_of_the_hippocampus.JPEG.
- Mossy_fiber_(hippocampus) isPrimaryTopicOf Mossy_fiber_(hippocampus).