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- Monomethyl_auristatin_E abstract "Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.MMAE is actually desmethyl-auristatin E; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin E itself.".
- Monomethyl_auristatin_E iupacName "(S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide".
- Monomethyl_auristatin_E thumbnail Monomethylauristatin_E.svg?width=300.
- Monomethyl_auristatin_E wikiPageID "24951332".
- Monomethyl_auristatin_E wikiPageLength "5971".
- Monomethyl_auristatin_E wikiPageOutDegree "36".
- Monomethyl_auristatin_E wikiPageRevisionID "678974399".
- Monomethyl_auristatin_E wikiPageWikiLink 4-Aminobenzoic_acid.
- Monomethyl_auristatin_E wikiPageWikiLink Amine.
- Monomethyl_auristatin_E wikiPageWikiLink Amino.
- Monomethyl_auristatin_E wikiPageWikiLink Anaplastic_large-cell_lymphoma.
- Monomethyl_auristatin_E wikiPageWikiLink Anaplastic_large_cell_lymphoma.
- Monomethyl_auristatin_E wikiPageWikiLink Antimitotic.
- Monomethyl_auristatin_E wikiPageWikiLink Antimitotic_agent.
- Monomethyl_auristatin_E wikiPageWikiLink Antineoplastic_agent.
- Monomethyl_auristatin_E wikiPageWikiLink Breast_cancer.
- Monomethyl_auristatin_E wikiPageWikiLink Brentuximab.
- Monomethyl_auristatin_E wikiPageWikiLink Brentuximab_vedotin.
- Monomethyl_auristatin_E wikiPageWikiLink CD30.
- Monomethyl_auristatin_E wikiPageWikiLink Cancer.
- Monomethyl_auristatin_E wikiPageWikiLink Caproic_acid.
- Monomethyl_auristatin_E wikiPageWikiLink Category:Mitotic_inhibitors.
- Monomethyl_auristatin_E wikiPageWikiLink Cathepsin.
- Monomethyl_auristatin_E wikiPageWikiLink Cell_division.
- Monomethyl_auristatin_E wikiPageWikiLink Chemotherapy.
- Monomethyl_auristatin_E wikiPageWikiLink Dolabella_auricularia.
- Monomethyl_auristatin_E wikiPageWikiLink Dolastatin.
- Monomethyl_auristatin_E wikiPageWikiLink Extracellular_fluid.
- Monomethyl_auristatin_E wikiPageWikiLink GPNMB.
- Monomethyl_auristatin_E wikiPageWikiLink Glembatumumab.
- Monomethyl_auristatin_E wikiPageWikiLink Glembatumumab_vedotin.
- Monomethyl_auristatin_E wikiPageWikiLink Glioma.
- Monomethyl_auristatin_E wikiPageWikiLink Hexanoic_acid.
- Monomethyl_auristatin_E wikiPageWikiLink Hodgkin_lymphoma.
- Monomethyl_auristatin_E wikiPageWikiLink Hodgkins_lymphoma.
- Monomethyl_auristatin_E wikiPageWikiLink In_vitro.
- Monomethyl_auristatin_E wikiPageWikiLink In_vivo.
- Monomethyl_auristatin_E wikiPageWikiLink International_Nonproprietary_Name.
- Monomethyl_auristatin_E wikiPageWikiLink Leukemia.
- Monomethyl_auristatin_E wikiPageWikiLink Lymphoma.
- Monomethyl_auristatin_E wikiPageWikiLink Maleimide.
- Monomethyl_auristatin_E wikiPageWikiLink Melanoma.
- Monomethyl_auristatin_E wikiPageWikiLink Methyl.
- Monomethyl_auristatin_E wikiPageWikiLink Methyl_group.
- Monomethyl_auristatin_E wikiPageWikiLink Mitotic_inhibitor.
- Monomethyl_auristatin_E wikiPageWikiLink Monoclonal_antibody.
- Monomethyl_auristatin_E wikiPageWikiLink Monomethyl_auristatin_F.
- Monomethyl_auristatin_E wikiPageWikiLink Paraaminobenzoic_acid.
- Monomethyl_auristatin_E wikiPageWikiLink Radical_(chemistry).
- Monomethyl_auristatin_E wikiPageWikiLink Tubulin.
- Monomethyl_auristatin_E wikiPageWikiLink Vinblastine.
- Monomethyl_auristatin_E wikiPageWikiLink File:MMAE-MAB-conjugate_skeletal.svg.
- Monomethyl_auristatin_E wikiPageWikiLinkText "(MM Auristatin E)".
- Monomethyl_auristatin_E wikiPageWikiLinkText "MMAE".
- Monomethyl_auristatin_E wikiPageWikiLinkText "Monomethyl auristatin E".
- Monomethyl_auristatin_E wikiPageWikiLinkText "monomethyl auristatin E".
- Monomethyl_auristatin_E hasPhotoCollection Monomethyl_auristatin_E.
- Monomethyl_auristatin_E imagefile "Monomethylauristatin E.svg".
- Monomethyl_auristatin_E imagesize "250".
- Monomethyl_auristatin_E iupacname "-N--N,3-dimethyl-2-butanamide".
- Monomethyl_auristatin_E othernames "Monomethylauristatin E".
- Monomethyl_auristatin_E verifiedfields "changed".
- Monomethyl_auristatin_E verifiedrevid "458641272".
- Monomethyl_auristatin_E watchedfields "changed".
- Monomethyl_auristatin_E wikiPageUsesTemplate Template:Chembox.
- Monomethyl_auristatin_E wikiPageUsesTemplate Template:Clear-left.
- Monomethyl_auristatin_E wikiPageUsesTemplate Template:Reflist.
- Monomethyl_auristatin_E subject Category:Mitotic_inhibitors.
- Monomethyl_auristatin_E hypernym Agent.
- Monomethyl_auristatin_E type Article.
- Monomethyl_auristatin_E type ChemicalCompound.
- Monomethyl_auristatin_E type ChemicalSubstance.
- Monomethyl_auristatin_E type Drug.
- Monomethyl_auristatin_E type Article.
- Monomethyl_auristatin_E type Chemical.
- Monomethyl_auristatin_E type Drug.
- Monomethyl_auristatin_E type Inhibitor.
- Monomethyl_auristatin_E type ChemicalObject.
- Monomethyl_auristatin_E type Thing.
- Monomethyl_auristatin_E type Q11173.
- Monomethyl_auristatin_E comment "Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody.".
- Monomethyl_auristatin_E label "Monomethyl auristatin E".
- Monomethyl_auristatin_E sameAs مونومثيل_أوريستاتين_إي.
- Monomethyl_auristatin_E sameAs مونومتیل_آریستاتین_ای.
- Monomethyl_auristatin_E sameAs m.09gbwk0.
- Monomethyl_auristatin_E sameAs Monometil_auristatin_E.
- Monomethyl_auristatin_E sameAs Monometil_auristatin_E.
- Monomethyl_auristatin_E sameAs Q6901739.
- Monomethyl_auristatin_E sameAs Q6901739.
- Monomethyl_auristatin_E wasDerivedFrom Monomethyl_auristatin_E?oldid=678974399.
- Monomethyl_auristatin_E depiction Monomethylauristatin_E.svg.
- Monomethyl_auristatin_E isPrimaryTopicOf Monomethyl_auristatin_E.