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- Mitochondrial_apoptosis-induced_channel abstract "The Mitochondrial Apoptosis-Induced Channel (or MAC), is an early marker of the onset of apoptosis. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli. MAC activity is detected by patch clamping mitochondria from apoptotic cells at the time of cytochrome c release.Members of the Bcl-2 protein family regulate apoptosis by controlling the formation of MAC: the pro-apoptotic members Bax and/or Bak form MAC, whereas the anti-apoptotic members like Bcl-2 or Bcl-xL prevent MAC formation. Once formed, MAC mediates the release of cytochrome c to the cytosol, triggering the commitment step of the mitochondrial apoptotic cascade. Depletion of MAC activity is accomplished pharmacologically by specific compounds, namely Bax Channel Inhibitors and MAC inhibitors. Either by knocking down MAC’s main components or by its pharmacological inhibition, the end result is prevention of cytochrome c release and apoptosis.".
- Mitochondrial_apoptosis-induced_channel thumbnail MacModel.jpg?width=300.
- Mitochondrial_apoptosis-induced_channel wikiPageID "14931374".
- Mitochondrial_apoptosis-induced_channel wikiPageLength "4703".
- Mitochondrial_apoptosis-induced_channel wikiPageOutDegree "14".
- Mitochondrial_apoptosis-induced_channel wikiPageRevisionID "660632705".
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Apoptosis.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Bcl-2.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Bcl-2-associated_X_protein.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Bcl-2_homologous_antagonist_killer.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Bcl-xL.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Category:Apoptosis.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Category:Cell_signaling.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Category:Programmed_cell_death.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Cytochrome_c.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink File:MacModel.jpg.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Ion_channel.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Mitochondrion.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Outer_mitochondrial_membrane.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLink Patch_clamp.
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLinkText "Mitochondrial apoptosis-induced channel".
- Mitochondrial_apoptosis-induced_channel wikiPageWikiLinkText "mitochondrial apoptosis-induced channel".
- Mitochondrial_apoptosis-induced_channel hasPhotoCollection Mitochondrial_apoptosis-induced_channel.
- Mitochondrial_apoptosis-induced_channel wikiPageUsesTemplate Template:Reflist.
- Mitochondrial_apoptosis-induced_channel subject Category:Apoptosis.
- Mitochondrial_apoptosis-induced_channel subject Category:Cell_signaling.
- Mitochondrial_apoptosis-induced_channel subject Category:Programmed_cell_death.
- Mitochondrial_apoptosis-induced_channel hypernym Marker.
- Mitochondrial_apoptosis-induced_channel type Place.
- Mitochondrial_apoptosis-induced_channel type Process.
- Mitochondrial_apoptosis-induced_channel comment "The Mitochondrial Apoptosis-Induced Channel (or MAC), is an early marker of the onset of apoptosis. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli.".
- Mitochondrial_apoptosis-induced_channel label "Mitochondrial apoptosis-induced channel".
- Mitochondrial_apoptosis-induced_channel sameAs m.03h225b.
- Mitochondrial_apoptosis-induced_channel sameAs Q6881847.
- Mitochondrial_apoptosis-induced_channel sameAs Q6881847.
- Mitochondrial_apoptosis-induced_channel wasDerivedFrom Mitochondrial_apoptosis-induced_channel?oldid=660632705.
- Mitochondrial_apoptosis-induced_channel depiction MacModel.jpg.
- Mitochondrial_apoptosis-induced_channel isPrimaryTopicOf Mitochondrial_apoptosis-induced_channel.