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- Midafotel abstract "Midafotel (CPPene; SDZ EAA 494) is a potent, competitive antagonist at the NMDA receptor. It was originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain. It looked very promising in in vitro trials proving to be a potent competitive antagonist at the NMDA without affecting other receptors. Research continued through to in vivo cat studies where it proved to limit damage after occluding the middle cerebral artery, leading to ischaemia. It also blocked photosensitive epilepsies in baboons.CPPene had a pharmacokinetic profile suitable for progressing to clinical trials, as it has no toxic by products, is excreted exclusively via the renal system, and remains unchanged in the brain.However, CPPene was removed from clinical trials, as it provided no suitable neuronal protection or beneficial treatment for epilepsy, and had side effects which led to many patients withdrawing from trials. A possible explanation for its lack of efficacy in trials is the relatively short therapeutic time window following ischaemic damage and the fact that a small amount of glutamate helps neuronal survival. It is also believed that some "pro-survival" genes are activated by NMDA receptors.".
- Midafotel atcPrefix "none".
- Midafotel casNumber "137424-80-7".
- Midafotel fdaUniiCode "7LYU6ZF84G".
- Midafotel iupacName "(R)-4-[(E)- 3-phosphonoprop- 2-enyl]piperazine- 2-carboxylic acid".
- Midafotel pubchem "6437356".
- Midafotel thumbnail CPPene.svg?width=300.
- Midafotel wikiPageID "17721929".
- Midafotel wikiPageLength "4726".
- Midafotel wikiPageOutDegree "12".
- Midafotel wikiPageRevisionID "667228857".
- Midafotel wikiPageWikiLink Antagonist_(pharmacology).
- Midafotel wikiPageWikiLink Category:Carboxylic_acids.
- Midafotel wikiPageWikiLink Category:NMDA_receptor_antagonists.
- Midafotel wikiPageWikiLink Category:Phosphonic_acids.
- Midafotel wikiPageWikiLink Category:Piperazines.
- Midafotel wikiPageWikiLink Competitive_inhibition.
- Midafotel wikiPageWikiLink Epilepsy.
- Midafotel wikiPageWikiLink Excitotoxicity.
- Midafotel wikiPageWikiLink NMDA_receptor.
- Midafotel wikiPageWikiLink NMDA_receptor_antagonist.
- Midafotel wikiPageWikiLink Neuropathic_pain.
- Midafotel wikiPageWikiLink Potency_(pharmacology).
- Midafotel wikiPageWikiLink Receptor_antagonist.
- Midafotel wikiPageWikiLinkText "Midafotel".
- Midafotel atcPrefix "none".
- Midafotel c "8".
- Midafotel casNumber "137424".
- Midafotel chemspiderid "4940497".
- Midafotel excretion "Renal".
- Midafotel h "15".
- Midafotel hasPhotoCollection Midafotel.
- Midafotel inchi "1".
- Midafotel inchikey "VZXMZMJSGLFKQI-ABVWVHJUBO".
- Midafotel iupacName "-4".
- Midafotel iupharLigand "4170".
- Midafotel molecularWeight "250.189".
- Midafotel n "2".
- Midafotel o "5".
- Midafotel p "1".
- Midafotel pubchem "6437356".
- Midafotel smiles "C1CNC/C=C/PO".
- Midafotel stdinchi "1".
- Midafotel stdinchikey "VZXMZMJSGLFKQI-ABVWVHJUSA-N".
- Midafotel synonyms "CPPene, Midafotel, SDZ EAA 494".
- Midafotel unii "7".
- Midafotel verifiedrevid "444504564".
- Midafotel width "200".
- Midafotel wikiPageUsesTemplate Template:Drugbox.
- Midafotel wikiPageUsesTemplate Template:Glutamatergics.
- Midafotel wikiPageUsesTemplate Template:Hallucinogens.
- Midafotel wikiPageUsesTemplate Template:Piperazines.
- Midafotel wikiPageUsesTemplate Template:Reflist.
- Midafotel subject Category:Carboxylic_acids.
- Midafotel subject Category:NMDA_receptor_antagonists.
- Midafotel subject Category:Phosphonic_acids.
- Midafotel subject Category:Piperazines.
- Midafotel hypernym Antagonist.
- Midafotel type Article.
- Midafotel type ChemicalSubstance.
- Midafotel type Drug.
- Midafotel type Group.
- Midafotel type Antagonist.
- Midafotel type Article.
- Midafotel type Chemical.
- Midafotel type Drug.
- Midafotel type Group.
- Midafotel type Heterocycle.
- Midafotel type ChemicalObject.
- Midafotel type Thing.
- Midafotel type Q8386.
- Midafotel comment "Midafotel (CPPene; SDZ EAA 494) is a potent, competitive antagonist at the NMDA receptor. It was originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain. It looked very promising in in vitro trials proving to be a potent competitive antagonist at the NMDA without affecting other receptors. Research continued through to in vivo cat studies where it proved to limit damage after occluding the middle cerebral artery, leading to ischaemia.".
- Midafotel label "Midafotel".
- Midafotel sameAs m.04797h6.
- Midafotel sameAs Midafotel.
- Midafotel sameAs Midafotel.
- Midafotel sameAs Q6841079.
- Midafotel sameAs Q6841079.
- Midafotel wasDerivedFrom Midafotel?oldid=667228857.
- Midafotel depiction CPPene.svg.
- Midafotel isPrimaryTopicOf Midafotel.