Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/MicroRNA> ?p ?o }
- MicroRNA abstract "A micro RNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals, and some viruses, which functions in RNA silencing and post-transcriptional regulation of gene expression.Encoded by eukaryotic nuclear DNA in plants and animals and by viral DNA in certain viruses whose genome is based on DNA, miRNAs function via base-pairing with complementary sequences within mRNA molecules. As a result, these mRNA molecules are silenced by one or more of the following processes: 1) cleavage of the mRNA strand into two pieces, 2) destabilization of the mRNA through shortening of its poly(A) tail, and 3) less efficient translation of the mRNA into proteins by ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals.miRNAs are well conserved in both plants and animals, and are thought to be a vital and evolutionarily ancient component of genetic regulation. While core components of the microRNA pathway are conserved between plants and animals, miRNA repertoires in the two kingdoms appear to have emerged independently with different primary modes of action. Plant miRNAs usually have near-perfect pairing with their mRNA targets, which induces gene repression through cleavage of the target transcripts. In contrast, animal miRNAs are able to recognize their target mRNAs by using as little as 6–8 nucleotides (the seed region) at the 5' end of the miRNA, which is not enough pairing to induce cleavage of the target mRNAs. Combinatorial regulation is a feature of miRNA regulation in animals. A given miRNA may have hundreds of different mRNA targets, and a given target might be regulated by multiple miRNAs.The first miRNA was discovered in the early 1990s. However, miRNAs were not recognized as a distinct class of biological regulators until the early 2000s. Since then, miRNA research has revealed different sets of miRNAs expressed in different cell types and tissuesand has revealed multiple roles for miRNAs in plant and animal development and in many other biological processes. Aberrant expression of miRNAs has been implicated in numerous disease states, and miRNA-based therapies are under investigation.Estimates of the average number of unique messenger RNAs that are targets for repression by a typical microRNA vary, depending on the method used to make the estimate, but several approaches show that mammalian miRNAs can have many unique targets. For example, an analysis of the miRNAs highly conserved in vertebrate animals shows that each of these miRNAs has, on average, roughly 400 conserved targets. Likewise, experiments show that a single miRNA can reduce the stability of hundreds of unique messenger RNAs, and other experiments show that a single miRNA may repress the production of hundreds of proteins, but that this repression often is relatively mild (less than 2-fold).".
- MicroRNA thumbnail MiRNA.svg?width=300.
- MicroRNA wikiPageExternalLink mirandola.
- MicroRNA wikiPageExternalLink mirnablog.com.
- MicroRNA wikiPageExternalLink mirob.interactome.ru.
- MicroRNA wikiPageExternalLink semirna.
- MicroRNA wikiPageExternalLink www.miR2Disease.org.
- MicroRNA wikiPageExternalLink www.mirbase.org.
- MicroRNA wikiPageExternalLink watch?v=_-9pROnSD-A.
- MicroRNA wikiPageID "156964".
- MicroRNA wikiPageLength "135935".
- MicroRNA wikiPageOutDegree "206".
- MicroRNA wikiPageRevisionID "682695123".
- MicroRNA wikiPageWikiLink 3_UTR.
- MicroRNA wikiPageWikiLink 5-3_exoribonuclease_2.
- MicroRNA wikiPageWikiLink 5_cap.
- MicroRNA wikiPageWikiLink AT-hook.
- MicroRNA wikiPageWikiLink AT_hook.
- MicroRNA wikiPageWikiLink Addiction.
- MicroRNA wikiPageWikiLink Adenosine.
- MicroRNA wikiPageWikiLink Adenosine_monophosphate.
- MicroRNA wikiPageWikiLink Adipocyte.
- MicroRNA wikiPageWikiLink Ageing.
- MicroRNA wikiPageWikiLink Aging.
- MicroRNA wikiPageWikiLink Alcohol_withdrawal_syndrome.
- MicroRNA wikiPageWikiLink Alcoholism.
- MicroRNA wikiPageWikiLink Alu_element.
- MicroRNA wikiPageWikiLink Alu_sequence.
- MicroRNA wikiPageWikiLink Animal.
- MicroRNA wikiPageWikiLink Antagomir.
- MicroRNA wikiPageWikiLink Anti-miRNA_oligonucleotides.
- MicroRNA wikiPageWikiLink Antisense.
- MicroRNA wikiPageWikiLink Anxiety_disorder.
- MicroRNA wikiPageWikiLink Apoptosis.
- MicroRNA wikiPageWikiLink Arabidopsis_thaliana.
- MicroRNA wikiPageWikiLink Argonaute.
- MicroRNA wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- MicroRNA wikiPageWikiLink BDNF.
- MicroRNA wikiPageWikiLink Bantam-miRNA.
- MicroRNA wikiPageWikiLink Basal_forebrain.
- MicroRNA wikiPageWikiLink Base-pair.
- MicroRNA wikiPageWikiLink Base_pair.
- MicroRNA wikiPageWikiLink Bipolar_disorder.
- MicroRNA wikiPageWikiLink Brain-derived_neurotrophic_factor.
- MicroRNA wikiPageWikiLink CEBPA.
- MicroRNA wikiPageWikiLink Caenorhabditis_elegans.
- MicroRNA wikiPageWikiLink Cancer.
- MicroRNA wikiPageWikiLink Cancer_stem_cell.
- MicroRNA wikiPageWikiLink Cancer_stem_cells.
- MicroRNA wikiPageWikiLink Cardiomyopathy.
- MicroRNA wikiPageWikiLink Category:Articles_with_inconsistent_citation_formats.
- MicroRNA wikiPageWikiLink Category:MicroRNA.
- MicroRNA wikiPageWikiLink Category:RNA.
- MicroRNA wikiPageWikiLink Causality.
- MicroRNA wikiPageWikiLink CeRNA.
- MicroRNA wikiPageWikiLink Cell_adhesion.
- MicroRNA wikiPageWikiLink Cell_cycle.
- MicroRNA wikiPageWikiLink Cell_growth.
- MicroRNA wikiPageWikiLink Cell_nucleus.
- MicroRNA wikiPageWikiLink Cell_signaling.
- MicroRNA wikiPageWikiLink Chronic_lymphocytic_leukemia.
- MicroRNA wikiPageWikiLink Cistron.
- MicroRNA wikiPageWikiLink Colon_cancer.
- MicroRNA wikiPageWikiLink Colorectal_cancer.
- MicroRNA wikiPageWikiLink Competing_endogenous_RNA_(CeRNA).
- MicroRNA wikiPageWikiLink Complementarity_(molecular_biology).
- MicroRNA wikiPageWikiLink Complementary_DNA.
- MicroRNA wikiPageWikiLink Conserved_sequence.
- MicroRNA wikiPageWikiLink Cytokine.
- MicroRNA wikiPageWikiLink Cytoplasm.
- MicroRNA wikiPageWikiLink DGCR8.
- MicroRNA wikiPageWikiLink DNA_methylation.
- MicroRNA wikiPageWikiLink DNA_mismatch_repair.
- MicroRNA wikiPageWikiLink DNA_repair.
- MicroRNA wikiPageWikiLink DNA_replication.
- MicroRNA wikiPageWikiLink Deadenylation.
- MicroRNA wikiPageWikiLink Decision-making.
- MicroRNA wikiPageWikiLink Decision_making.
- MicroRNA wikiPageWikiLink DiGeorge_Syndrome.
- MicroRNA wikiPageWikiLink DiGeorge_syndrome.
- MicroRNA wikiPageWikiLink Diabetes.
- MicroRNA wikiPageWikiLink Diabetes_mellitus.
- MicroRNA wikiPageWikiLink Dicer.
- MicroRNA wikiPageWikiLink Dicer-like1.
- MicroRNA wikiPageWikiLink Dopamine_receptor_D1.
- MicroRNA wikiPageWikiLink Double-stranded_RNA.
- MicroRNA wikiPageWikiLink Drosha.
- MicroRNA wikiPageWikiLink Drosophila.
- MicroRNA wikiPageWikiLink Ectopic_expression.
- MicroRNA wikiPageWikiLink Epigenetic_methylation.
- MicroRNA wikiPageWikiLink Epigenetics.
- MicroRNA wikiPageWikiLink Eukaryote.
- MicroRNA wikiPageWikiLink Eukaryotic_translation.
- MicroRNA wikiPageWikiLink Exon.
- MicroRNA wikiPageWikiLink FOSB.
- MicroRNA wikiPageWikiLink Five-prime_cap.
- MicroRNA wikiPageWikiLink FosB.
- MicroRNA wikiPageWikiLink G-quadruplex.
- MicroRNA wikiPageWikiLink Gene.
- MicroRNA wikiPageWikiLink Gene_expression.