Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Methylphenidate> ?p ?o }
- Methylphenidate abstract "Methylphenidate (trade names Concerta, Methylin, Medikinet, Ritalin, Equasym XL, Quillivant XR, Metadate) is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Methylphenidate has been studied and researched for over 50 years and has a very good efficacy and safety record for the treatment of ADHD. The original patent was owned by CIBA, now Novartis Corporation. It was first licensed by the U.S. Food and Drug Administration (FDA) in 1955 for treating what was then known as hyperactivity.Prescribed to patients beginning in 1960, the drug has become increasingly prescribed since the 1990s, when the diagnosis of ADHD itself became more widely accepted. Between 2007 and 2012 methylphenidate prescriptions increased by 50% in Britain and in 2013 global methylphenidate consumption increased to 2.4 billion doses, a 66% increase compared to the year before. The US continues to account for more than 80% of global consumption.ADHD and other similar conditions are believed to be linked to sub-performance of the dopamine and norepinephrine functions in the brain, primarily in the prefrontal cortex, responsible for self-regulatory function (e.g., inhibition, motivation, and memory) and executive function (e.g., reasoning, organizing, problem solving, and planning). Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor. Methylphenidate acts by blocking the dopamine transporter and norepinephrine transporter, leading to increased concentrations of dopamine and norepinephrine within the synaptic cleft. This effect in turn leads to increased neurotransmission of dopamine and norepinephrine. Methylphenidate is also a 5HT1A receptor agonist.".
- Methylphenidate thumbnail Methylphenidate-2D-skeletal.svg?width=300.
- Methylphenidate wikiPageExternalLink dpdirect.jsp?name=Methylphenidate.
- Methylphenidate wikiPageExternalLink bnlpr092998.html.
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- Methylphenidate wikiPageRevisionID "683595412".
- Methylphenidate wikiPageWikiLink 2-Benzylpiperidine.
- Methylphenidate wikiPageWikiLink 3,4-Dichloromethylphenidate.
- Methylphenidate wikiPageWikiLink 4-Methylmethylphenidate.
- Methylphenidate wikiPageWikiLink 5-HT1A_receptor.
- Methylphenidate wikiPageWikiLink 5-HT2B_receptor.
- Methylphenidate wikiPageWikiLink 5HT1A.
- Methylphenidate wikiPageWikiLink Abdominal_pain.
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- Methylphenidate wikiPageWikiLink Akathisia.
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- Methylphenidate wikiPageWikiLink Amphetamine.
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- Methylphenidate wikiPageWikiLink Anorexia_(symptom).
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- Methylphenidate wikiPageWikiLink Antipsychotic.
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- Methylphenidate wikiPageWikiLink Attention-deficit_hyperactivity_disorder.
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- Methylphenidate wikiPageWikiLink Barbiturate.
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- Methylphenidate wikiPageWikiLink Benzedrine.
- Methylphenidate wikiPageWikiLink Benzodiazepine.
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- Methylphenidate wikiPageWikiLink British_Medical_Journal.
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- Methylphenidate wikiPageWikiLink Bruxism.
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- Methylphenidate wikiPageWikiLink Cardiac_arrhythmia.
- Methylphenidate wikiPageWikiLink Catecholamine.
- Methylphenidate wikiPageWikiLink Category:Amphetamine.
- Methylphenidate wikiPageWikiLink Category:Biology_of_bipolar_disorder.
- Methylphenidate wikiPageWikiLink Category:Carboxylate_esters.
- Methylphenidate wikiPageWikiLink Category:Euphoriants.
- Methylphenidate wikiPageWikiLink Category:Methyl_esters.
- Methylphenidate wikiPageWikiLink Category:Methylphenidate.
- Methylphenidate wikiPageWikiLink Category:Nootropics.
- Methylphenidate wikiPageWikiLink Category:Norepinephrine-dopamine_reuptake_inhibitors.
- Methylphenidate wikiPageWikiLink Category:Piperidines.
- Methylphenidate wikiPageWikiLink Category:Sigma_agonists.
- Methylphenidate wikiPageWikiLink Category:Stimulants.
- Methylphenidate wikiPageWikiLink Category:Sympathomimetic_amines.
- Methylphenidate wikiPageWikiLink Category:Treatment_and_management_of_attention_deficit_hyperactivity_disorder.
- Methylphenidate wikiPageWikiLink Category:Vasoconstrictors.
- Methylphenidate wikiPageWikiLink Central_nervous_system.
- Methylphenidate wikiPageWikiLink Charles_Bradley_(doctor).
- Methylphenidate wikiPageWikiLink Chemical_classification.
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- Methylphenidate wikiPageWikiLink Ciba-Geigy.
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- Methylphenidate wikiPageWikiLink Cocaethylene.
- Methylphenidate wikiPageWikiLink Cocaine.
- Methylphenidate wikiPageWikiLink Cognitive_behavioral_therapy.
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- Methylphenidate wikiPageWikiLink Cognitive_inhibition.
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- Methylphenidate wikiPageWikiLink Convention_on_Psychotropic_Substances.
- Methylphenidate wikiPageWikiLink Convulsion.
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- Methylphenidate wikiPageWikiLink D-threo-methylphenidate.
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- Methylphenidate wikiPageWikiLink Daytrana.
- Methylphenidate wikiPageWikiLink Delirium.
- Methylphenidate wikiPageWikiLink Depression_(mood).
- Methylphenidate wikiPageWikiLink Derivative.
- Methylphenidate wikiPageWikiLink Dexmethylphenidate.
- Methylphenidate wikiPageWikiLink Dextromethylphenidate.
- Methylphenidate wikiPageWikiLink Dextrorotary.