Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Metadoxine> ?p ?o }
Showing triples 1 to 100 of
100
with 100 triples per page.
- Metadoxine abstract "Metadoxine, also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine improved the clinical signs of acute alcohol intoxication and accelerated alcohol clearance from the blood Metadoxine extended release is being evaluated as a treatment in human clinical trials for individuals with attention deficit hyperactivity disorder (ADHD) and for individuals with fragile X syndrome.Metadoxine is an ion pair salt of pyridoxine and L-Pyroglutamate. Pyridoxine (vitamin B6) is a precursor of coenzymes including pyridoxal 5’-phosphate (PLP), which accelerates the metabolic degradation of ethanol and prevents adenosine triphosphate (ATP) inactivation by acetaldehyde. Pyridoxal phosphate dependent enzymes also play a role in the biosynthesis of four important neurotransmitters: serotonin (5-HT), epinephrine, norepinephrine and GABA: see vitamin B6 functions. L-pyroglutamate (L-PGA) is present in the diet and is produced endogenously by enzymatic conversion of gamma-glutamyl amino acids to L-PGA and free amino acids. In the central nervous system (CNS), L-PGA was found to have a role in composition of neuro-active molecules. Its production has been linked to hepatic gamma-glutamyl transferase activity and levels of reduced glutathione (GSH). Lastly, it was shown that L-PGA facilitates ATP synthesis by stimulating de novo synthesis of purines.".
- Metadoxine atcPrefix "N07BB".
- Metadoxine casNumber "0074536-44-0".
- Metadoxine iupacName "(L)-Proline, 5-oxo-, compd. with 5-hydroxy-6-methylpyridine-3,4-dimethanol (1:1)".
- Metadoxine pubchem "115198".
- Metadoxine thumbnail Metadoxine.svg?width=300.
- Metadoxine wikiPageID "40993920".
- Metadoxine wikiPageLength "16010".
- Metadoxine wikiPageOutDegree "37".
- Metadoxine wikiPageRevisionID "683640965".
- Metadoxine wikiPageWikiLink 5-HT2B_receptor.
- Metadoxine wikiPageWikiLink Acetaldehyde.
- Metadoxine wikiPageWikiLink Acetaldehyde_dehydrogenase.
- Metadoxine wikiPageWikiLink Adenosine_triphosphate.
- Metadoxine wikiPageWikiLink Alanine_aminotransferase.
- Metadoxine wikiPageWikiLink Alanine_transaminase.
- Metadoxine wikiPageWikiLink Alcohol_intoxication.
- Metadoxine wikiPageWikiLink Alcoholism.
- Metadoxine wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- Metadoxine wikiPageWikiLink Category:Alcohol_abuse.
- Metadoxine wikiPageWikiLink Category:Drugs_acting_on_the_nervous_system.
- Metadoxine wikiPageWikiLink Category:Hepatology.
- Metadoxine wikiPageWikiLink Category:Nootropics.
- Metadoxine wikiPageWikiLink Category:Pyridines.
- Metadoxine wikiPageWikiLink Category:Pyrrolidones.
- Metadoxine wikiPageWikiLink Category:Serotonin_antagonists.
- Metadoxine wikiPageWikiLink Epinephrine.
- Metadoxine wikiPageWikiLink Extracellular_signal-regulated_kinases.
- Metadoxine wikiPageWikiLink Fatty_liver.
- Metadoxine wikiPageWikiLink Fragile_X_syndrome.
- Metadoxine wikiPageWikiLink GABA_transaminase.
- Metadoxine wikiPageWikiLink GABA_transporter.
- Metadoxine wikiPageWikiLink Gamma-Aminobutyric_acid.
- Metadoxine wikiPageWikiLink Gamma-glutamyl_transpeptidase.
- Metadoxine wikiPageWikiLink Glutathione.
- Metadoxine wikiPageWikiLink Intravenous.
- Metadoxine wikiPageWikiLink Intravenous_therapy.
- Metadoxine wikiPageWikiLink Lipid_peroxidation.
- Metadoxine wikiPageWikiLink Mouth.
- Metadoxine wikiPageWikiLink Norepinephrine.
- Metadoxine wikiPageWikiLink Protein_kinase_B.
- Metadoxine wikiPageWikiLink Pyridoxal_phosphate.
- Metadoxine wikiPageWikiLink Pyridoxine.
- Metadoxine wikiPageWikiLink Pyroglutamic_acid.
- Metadoxine wikiPageWikiLink Serotonin.
- Metadoxine wikiPageWikiLink Tumor_necrosis_factor_alpha.
- Metadoxine wikiPageWikiLink Vitamin_B6.
- Metadoxine wikiPageWikiLinkText "Metadoxine".
- Metadoxine atcPrefix "N07BB".
- Metadoxine c "13".
- Metadoxine casNumber "74536".
- Metadoxine chemspiderid "23089666".
- Metadoxine colwidth "30".
- Metadoxine drugName "Metadoxine".
- Metadoxine h "18".
- Metadoxine hasPhotoCollection Metadoxine.
- Metadoxine inchi "1".
- Metadoxine inchikey "HYILJNQLQITGSP-VWMHFEHEBB".
- Metadoxine iupacName "(L)-Proline, 5-oxo-, compd. with 5-hydroxy-6-methylpyridine-3,4-dimethanol".
- Metadoxine molecularWeight "298.29".
- Metadoxine n "2".
- Metadoxine o "6".
- Metadoxine pubchem "115198".
- Metadoxine routesOfAdministration Intravenous.
- Metadoxine routesOfAdministration Intravenous_therapy.
- Metadoxine routesOfAdministration Mouth.
- Metadoxine smiles "Cc1cO.C1CCN[C@@H]1CCO".
- Metadoxine stdinchi "1".
- Metadoxine stdinchikey "HYILJNQLQITGSP-VWMHFEHESA-N".
- Metadoxine verifiedfields "changed".
- Metadoxine verifiedrevid "placeholder".
- Metadoxine watchedfields "changed".
- Metadoxine width "250".
- Metadoxine wikiPageUsesTemplate Template:Drugbox.
- Metadoxine wikiPageUsesTemplate Template:Drugs_used_in_addictive_disorders.
- Metadoxine wikiPageUsesTemplate Template:GABAergics.
- Metadoxine wikiPageUsesTemplate Template:Reflist.
- Metadoxine wikiPageUsesTemplate Template:Serotonergics.
- Metadoxine subject Category:Alcohol_abuse.
- Metadoxine subject Category:Drugs_acting_on_the_nervous_system.
- Metadoxine subject Category:Hepatology.
- Metadoxine subject Category:Nootropics.
- Metadoxine subject Category:Pyridines.
- Metadoxine subject Category:Pyrrolidones.
- Metadoxine subject Category:Serotonin_antagonists.
- Metadoxine hypernym Drug.
- Metadoxine type ChemicalSubstance.
- Metadoxine type Drug.
- Metadoxine type ChemicalObject.
- Metadoxine type Thing.
- Metadoxine type Q8386.
- Metadoxine comment "Metadoxine, also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.".
- Metadoxine label "Metadoxine".
- Metadoxine sameAs m.010hnvqb.
- Metadoxine sameAs Q18344013.
- Metadoxine sameAs Q18344013.
- Metadoxine wasDerivedFrom Metadoxine?oldid=683640965.
- Metadoxine depiction Metadoxine.svg.
- Metadoxine isPrimaryTopicOf Metadoxine.
- Metadoxine name "Metadoxine".