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- Matrix_metallopeptidase_13 abstract "Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene. It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form. It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain PDB: 1PEX . Although the actual mechanism has not been described, the hemopexin domain participates in collagen degradation, the catalytic domain alone being particularly inefficient in collagen degradation. During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly overexpressed; this occurs in human carcinomas, rheumatoid arthritis and osteoarthritis.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.".
- Matrix_metallopeptidase_13 entrezgene "4322".
- Matrix_metallopeptidase_13 wikiPageExternalLink merops.cgi?id=M10.013.
- Matrix_metallopeptidase_13 wikiPageID "14700870".
- Matrix_metallopeptidase_13 wikiPageLength "8813".
- Matrix_metallopeptidase_13 wikiPageOutDegree "6".
- Matrix_metallopeptidase_13 wikiPageRevisionID "678960532".
- Matrix_metallopeptidase_13 wikiPageWikiLink Category:Human_proteins.
- Matrix_metallopeptidase_13 wikiPageWikiLink Category:Peptidase.
- Matrix_metallopeptidase_13 wikiPageWikiLink Enzyme.
- Matrix_metallopeptidase_13 wikiPageWikiLink Gene.
- Matrix_metallopeptidase_13 wikiPageWikiLink MEROPS.
- Matrix_metallopeptidase_13 wikiPageWikiLink Matrix_metalloproteinase.
- Matrix_metallopeptidase_13 wikiPageWikiLinkText "MMP13".
- Matrix_metallopeptidase_13 wikiPageWikiLinkText "Matrix metallopeptidase 13".
- Matrix_metallopeptidase_13 hasPhotoCollection Matrix_metallopeptidase_13.
- Matrix_metallopeptidase_13 requireManualInspection "no".
- Matrix_metallopeptidase_13 summaryText "Proteins of the matrix metalloproteinase family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.".
- Matrix_metallopeptidase_13 updateCitations "yes".
- Matrix_metallopeptidase_13 updatePage "yes".
- Matrix_metallopeptidase_13 updateProteinBox "yes".
- Matrix_metallopeptidase_13 updateSummary "yes".
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:Gene-11-stub.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:Metalloendopeptidases.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:PBB.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:PBB_Controls.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:PBB_Further_reading.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:PBB_Summary.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:PDB.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:PDB_Gallery.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:Refbegin.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:Refend.
- Matrix_metallopeptidase_13 wikiPageUsesTemplate Template:Reflist.
- Matrix_metallopeptidase_13 subject Category:Human_proteins.
- Matrix_metallopeptidase_13 subject Category:Peptidase.
- Matrix_metallopeptidase_13 hypernym Enzyme.
- Matrix_metallopeptidase_13 type Biomolecule.
- Matrix_metallopeptidase_13 type Protein.
- Matrix_metallopeptidase_13 type Thing.
- Matrix_metallopeptidase_13 type Q206229.
- Matrix_metallopeptidase_13 type Q8054.
- Matrix_metallopeptidase_13 comment "Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene. It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form. It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain PDB: 1PEX .".
- Matrix_metallopeptidase_13 label "Matrix metallopeptidase 13".
- Matrix_metallopeptidase_13 sameAs m.03gtk8n.
- Matrix_metallopeptidase_13 sameAs Q6787875.
- Matrix_metallopeptidase_13 sameAs Q6787875.
- Matrix_metallopeptidase_13 wasDerivedFrom Matrix_metallopeptidase_13?oldid=678960532.
- Matrix_metallopeptidase_13 isPrimaryTopicOf Matrix_metallopeptidase_13.